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Akademický článek

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miRNA-506-3p Directly Regulates rs10754339 (A/G) in the Immune Checkpoint Protein B7-H4 in Breast Cancer

Autor: R.A. Assal, Mohamed Z. Gad, Germine Saad El Din, Rana Ahmed Youness

Publikováno v: MicroRNA. 9:346-353

Background: B7-H4 is a novel immune checkpoint protein that negatively regulates T cell activation and function. It is overexpressed in many malignant tumors, including Breast Cancer (BC). It was reported that the presence of the single nucleotide po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a35943a0ba7c5b5062a447f4427805e
https://doi.org/10.2174/2211536609666201209152949

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Akademický článek

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The association of megalin and cubilin genetic variants with serum levels of 25-hydroxvitamin D and the incidence of acute coronary syndrome in Egyptians: A case control study

Autor: Gamal M. Shaban, Mohamed Z. Gad, Mohamed F. Abdel Rahman, R.A. Assal, Sally I. Hassanein, Raghda A. Elsabbagh, Rasha S. Hanafi

Publikováno v: Journal of Advanced Research, Vol 21, Iss, Pp 49-56 (2020)
Journal of Advanced Research

Graphical abstract
Megalin and cubilin are two receptors that mediate endocytosis of 25-hydroxyvitamin D (25(OH)D) for its final activation by hydroxylation. The aim of the present study was to evaluate the association of polymorphisms in megali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba47c7135b388e407e6825878fae81e
https://doi.org/10.1016/j.jare.2019.09.006

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Contribution of CYP27B1 and CYP24A1 genetic variations to the incidence of acute coronary syndrome and to vitamin D serum level

Autor: Mohamed F. Abdel Rahman, R.A. Assal, Mohamed Z. Gad, Sally I. Hassanein, Marina Sherif Fam, Rasha S. Hanafi

Publikováno v: Canadian Journal of Physiology and Pharmacology. 97:1152-1158

Cardiovascular diseases remain a major public health burden worldwide. It was reported that vitamin D protects the cardiovascular system through several mechanisms mainly by hindering atherosclerosis development. Genetic variations in vitamin D metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc75afc05250124219624de703e0b50f
https://doi.org/10.1139/cjpp-2019-0258

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An acetylated derivative of vitexin halts MDA-MB-231 cellular progression and improves its immunogenic profile through tuning miR- 20a-MICA/B axis

Autor: Aya R Awad, Rana Ahmed Youness, Amira Abdel Motaal, Hesham I. El-Askary, M. Ibrahim, Mohamed Z. Gad, R.A. Assal

Publikováno v: Natural Product Research. 35:3126-3130

The activating immune ligands, MICA/B, act as a "kill me" signal through the NKG2D receptor expressed on natural killer (NK) cells. Recently, the oncogenic miR-20a was found to mediate immune escape through repressing MICA/B levels in breast cancer (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb63f6c90b5ab4a50ef9f138ce3cec5c
https://doi.org/10.1080/14786419.2019.1686372

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Hindering the Synchronization Between miR-486-5p and H19 lncRNA by Hesperetin Halts Breast Cancer Aggressiveness Through Tuning ICAM-1

Autor: Hesham I. El-Askary, Amira Abdel Motaal, Rana Ahmed Youness, R.A. Soliman, R.A. Assal, Ahmed El Sebaei, Ramah M Abdallah, A. Elkhouly, Nahed El Meckawy

Publikováno v: Anti-cancer agents in medicinal chemistry. 22(3)

Background: Recently, a novel crosstalk between non-coding RNAs (ncRNAs) has been casted. However, this has been seldom investigated in metastatic BC (mBC). H19 and miR-486-5p role in mBC are controversial. ICAM-1 is a recently recognized metastatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24784e29feb88b655840a3dda13f7b76
https://pubmed.ncbi.nlm.nih.gov/33882812

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A novel role of sONE/NOS3/NO signaling cascade in mediating hydrogen sulphide bilateral effects on triple negative breast cancer progression

Autor: Mohamed Z. Gad, Amira Abdel Motaal, Rana Ahmed Youness, R.A. Assal

Publikováno v: Nitric Oxide. 80:12-23

Hydrogen sulphide (H2S) gas has been recognized as an intracellular mediator influencing an array of signaling pathways. Yet, the role of H2S in cancer progression has been controversial. This study aims to unravel the role of exogenous H2S in triple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4073d090350e87dcb77a93dce1e65d
https://doi.org/10.1016/j.niox.2018.07.004

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