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Akademický článek

Integrating mangrove growth and failure in coastal flood protection designs

Autor: A. Gijón Mancheño, V. Vuik, B. K. van Wesenbeeck, S. N. Jonkman, R. van Hespen, J. R. Moll, S. Kazi, I. Urrutia, M. van Ledden

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)

Abstract Mangrove forests reduce wave attack along tropical and sub-tropical coastlines, decreasing the wave loads acting on coastal protection structures. Mangrove belts seaward of embankments can therefore lower their required height and decrease t

Externí odkaz: https://doaj.org/article/214a1279f3464d25ba00f19829500c34

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Polynuclear heterocyclic systems. Part V: Heterocycles related to steroids and C-nor-steroids

Autor: S. Skolnik, R. van Hes, H. O. Huisman, Upendra K. Pandit

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 87:151-160

The preparation of 6-methoxy-2-(2′-oxocyclopentyl-1-tetralone (I) and 2-(2′-oxocyclopentyl)quinolizidin-1-one (II) is described. Diketones I and II have been converted to heterocyclic systems related to steroids and C-nor-steroids.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0eb395b4e3e02ada8f7619e4b17a8950
https://doi.org/10.1002/recl.19680870206

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Heterocyclic Steroids. Part XI 1-Hydroxy-1-vinylquinolizidine - its synthesis, stereochemistry and attempted conversion to 5-azasteroids

Autor: Upendra K. Pandit, R. van Hes, H. O. Huisman

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 86:1255-1262

Reaction of vinylmagnesium bromide with quinolizidine-1-one yielded a mixture of two stereoisomeric 1-hydroxy-1-vinylquinolizidine systems (III and IV). Structural assignments of the latter are based upon infrared, nuclear magnetic resonance and mass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::030bdeca863e19633165025ceaedbe89
https://doi.org/10.1002/recl.19670861112

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Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives

Autor: I, van Wijngaarden, D, Hamminga, R, van Hes, P J, Standaar, J, Tipker, M T, Tulp, F, Mol, B, Olivier, A, de Jonge

Publikováno v: Journal of medicinal chemistry. 36(23)

On the basis of the structures of ondansetron and GR 65,630, its ring-opened C-linked methylimidazole analogue, novel 1,7-annelated indole derivatives were synthesized as potential 5-HT3 antagonists. Receptor binding studies show that all compounds d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b304c2400ee9f7d7d23b97d43dcc006
https://pubmed.ncbi.nlm.nih.gov/8246239

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The synthesis of 2-azapodophyllotoxins

Autor: J. Van der Eycken, W. Veerman, R. Van Hes, M. Vandewalle, Antonius Hulkenberg, J.-P. Bosmans

Publikováno v: Tetrahedron Letters. 30:3877-3880

2-Azapodophyllotoxins, tetrahydroisoquinoline analogues of podophyllotoxin have been synthesized. They constitute a new class of highly potent anti-tumor agents.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75d2399d363201c1d956dc9d2e7fbb26
https://doi.org/10.1016/s0040-4039(01)80682-1

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Benzoylphenylurea Insecticides

Autor: W. Maas, R. van Hes, A. C. Grosscurt, D. H. Deul

Publikováno v: Insektizide · Bakterizide · Oomyceten-Fungizide / Biochemische und biologische Methoden · Naturstoffe / Insecticides · Bactericides · Oomycete Fungicides / Biochemical and Biological Methods · Natural Products ISBN: 9783642677809

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5e0893080d4d6068458e5669786faf6
https://doi.org/10.1007/978-3-642-67778-6_9

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ChemInform Abstract: 2-Phenylpyrroles as Conformationally Restricted Benzamide Analogues. A New Class of Potential Antipsychotics. Part 1

Autor: R. Van Hes, M. Th. M. Tulp, C.G. Kruse, J.A.M. van der Heyden, I. Van Wijngaarden

Publikováno v: ChemInform. 19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dce1d54ce3dce77bb93e374e56b7c389
https://doi.org/10.1002/chin.198815241

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ChemInform Abstract: New Methods for the Synthesis of 2-Arylpyrroles

Autor: A. Van De Kuilen, J. A. J. Den Hartog, J. P. Bouw, R. Van Hes, C.G. Kruse

Publikováno v: ChemInform. 19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6dbe72f791ea4c710d7af4b0a8f8ab24
https://doi.org/10.1002/chin.198820142

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ChemInform Abstract: SYNTH. UND VIRICIDE AKTIVITAETEN VON ADAMANTAN-SPIROVERBINDUNGEN 2. MITT

Autor: A. Peters, R. Van Hes, A. Smit, T. Kralt

Publikováno v: Chemischer Informationsdienst. 3

Das fruher beschriebene Adamantandicarbonsaureanhydrid (I) liefert uber den Monoester (II) die Carbinol-carbonsaure (III), die zum Lacton (IV) cyclisiert wird.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4da43041d041f1e42acbb70ff1dfcc47
https://doi.org/10.1002/chin.197221240

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