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Publikováno v:
Journal of Neuroscience Research. 91:196-210
The upregulation of genes normally associated with development may occur in the adult after spinal cord injury (SCI). To test this, we performed real-time RT-PCR array analysis of mouse spinal cord mRNAs comparing embryonic day (E)14.5 spinal cord wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02e2ca89838956769703913826b3286
https://doi.org/10.1002/jnr.23151
https://doi.org/10.1002/jnr.23151
Autor:
Junfang Wu, Ahdeah Pajoohesh-Ganji, Matthew Whittaker, April Sharp, Ransom Wyse, Hyun Joon Lee, Jean R. Wrathall, Laila J. Zai
Publikováno v:
Glia. 60:281-294
The adult spinal cord contains a pool of endogenous glial precursor cells, which spontaneously respond to spinal cord injury (SCI) with increased proliferation. These include oligodendrocyte precursor cells that express the NG2 proteoglycan and can d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd743770624ddb4dfd997993924f3ee
https://doi.org/10.1002/glia.21262
https://doi.org/10.1002/glia.21262
Publikováno v:
Journal of Neuroscience Research. 89:628-638
The close homolog of the adhesion molecule L1 (CHL1) is important during CNS development, but a study with CHL1 knockout mice showed greater functional recovery after spinal cord injury (SCI) in its absence. We investigated CHL1 expression from 1 to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b4f4c7539ef60b4bbd2da4323b7041
https://doi.org/10.1002/jnr.22598
https://doi.org/10.1002/jnr.22598
Publikováno v:
Journal of Neurochemistry. 76:797-805
Quantitative western blot analysis in laminectomy control spinal cords of adult rats was used to provide the first report of the normal expression patterns of the N1, C1, C2 and C2' cassettes in the cervical, thoracic and lumbar regions of the spinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::820c1b0fefa0bc37528ba85139555ff1
https://doi.org/10.1046/j.1471-4159.2001.00069.x
https://doi.org/10.1046/j.1471-4159.2001.00069.x
Autor:
Jean R. Wrathall, Soonmoon Yoo
Publikováno v:
Developmental Neurobiology. 67:860-874
NG2+ cells in the adult rat spinal cord proliferate after spinal cord injury (SCI) and are postulated to differentiate into mature glia to replace some of those lost to injury. To further study these putative endogenous precursors, tissue at 3 days a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152a52bebdc1c133b0755dd7680c4cff
https://doi.org/10.1002/dneu.20369
https://doi.org/10.1002/dneu.20369
Autor:
Jean R. Wrathall, Judith M. Lytle
Publikováno v:
European Journal of Neuroscience. 25:1711-1724
Studies in the rat have shown that contusive spinal cord injury (SCI) results in devastating pathology, including significant loss of mature oligodendrocytes and astrocytes even in spared white matter. Subsequently, there is increased proliferation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f206ac55be83e087b3d51ca4a208a48a
https://doi.org/10.1111/j.1460-9568.2007.05390.x
https://doi.org/10.1111/j.1460-9568.2007.05390.x
Publikováno v:
Journal of Neurotrauma. 23:1726-1738
Following contusive spinal cord injury (SCI), 50% of oligodendrocytes in the residual white matter are lost within 24 h. NG2-expressing cell proliferation is maximal 3 days after SCI, and may be the source of mature oligodendrocytes and astrocytes th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a547c12bde62b58cba159c1819ea6f9
https://doi.org/10.1089/neu.2006.23.1726
https://doi.org/10.1089/neu.2006.23.1726
Autor:
Jean R. Wrathall, Philberta Y. Leung
Publikováno v:
Experimental Neurology. 202:225-237
Young rats display an accelerated rate of locomotor recovery after contusive spinal cord injury (SCI) compared to adults subjected to a similar standardized injury. We examined possible differences in the responses to SCI at the injury site and in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86eb9f37908ef3e928e8794963589ca7
https://doi.org/10.1016/j.expneurol.2006.06.007
https://doi.org/10.1016/j.expneurol.2006.06.007
Autor:
Laila J. Zai, Jean R. Wrathall
Publikováno v:
Glia. 50:247-257
After spinal cord injury (SCI), about 50% of the oligodendrocytes and astrocytes in the residual white matter at the injury site are lost by 24 h. However, chronically after SCI, the density of oligodendrocytes is normal. Previous studies have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53bfe8cd3363ce0be3a51d6e26cb649b
https://doi.org/10.1002/glia.20176
https://doi.org/10.1002/glia.20176