Zobrazeno 1 - 10
of 263
pro vyhledávání: '"R. Worrall"'
Autor:
Tadeo Moreno-Chicano, Leiah M. Carey, Danny Axford, John H. Beale, R. Bruce Doak, Helen M. E. Duyvesteyn, Ali Ebrahim, Robert W. Henning, Diana C. F. Monteiro, Dean A. Myles, Shigeki Owada, Darren A. Sherrell, Megan L. Straw, Vukica Šrajer, Hiroshi Sugimoto, Kensuke Tono, Takehiko Tosha, Ivo Tews, Martin Trebbin, Richard W. Strange, Kevin L. Weiss, Jonathan A. R. Worrall, Flora Meilleur, Robin L. Owen, Reza A. Ghiladi, Michael A. Hough
Publikováno v:
IUCrJ, Vol 9, Iss 5, Pp 610-624 (2022)
Room-temperature macromolecular crystallography allows protein structures to be determined under close-to-physiological conditions, permits dynamic freedom in protein motions and enables time-resolved studies. In the case of metalloenzymes that are h
Externí odkaz:
https://doaj.org/article/288bb78b21864584a71fa98e261fa74e
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The interaction between macromolecular proteins and small molecule ligands is an essential component of cellular function. Such ligands may include enzyme substrates, molecules involved in cellular signalling or pharmaceutical drugs. Together with bi
Externí odkaz:
https://doaj.org/article/0ef51fc8b5c94b60b1f1fce88618c681
Autor:
Dustin T. Duncan, Su Hyun Park, Yen-Tyng Chen, Brett Dolotina, Wilder R. Worrall, Hillary Hanson, Mainza Durrell, Gustavo Arruda Franco, Stephen S. Morse, John A. Schneider
Publikováno v:
Vaccines, Vol 11, Iss 4, p 787 (2023)
Background: Although there is limited literature on medication adherence (including HIV care engagement) and COVID-19 vaccine hesitancy in general populations (i.e., non-sexual or gender minority populations), even less is known about whether HIV car
Externí odkaz:
https://doaj.org/article/3c2e3b503adc4dca9403efc59bdfe54d
Autor:
Tadeo Moreno-Chicano, Ali Ebrahim, Danny Axford, Martin V. Appleby, John H. Beale, Amanda K. Chaplin, Helen M. E. Duyvesteyn, Reza A. Ghiladi, Shigeki Owada, Darren A. Sherrell, Richard W. Strange, Hiroshi Sugimoto, Kensuke Tono, Jonathan A. R. Worrall, Robin L. Owen, Michael A. Hough
Publikováno v:
IUCrJ, Vol 6, Iss 6, Pp 1074-1085 (2019)
High-throughput X-ray crystal structures of protein–ligand complexes are critical to pharmaceutical drug development. However, cryocooling of crystals and X-ray radiation damage may distort the observed ligand binding. Serial femtosecond crystallog
Externí odkaz:
https://doaj.org/article/ad7f2d9a92a74ab3b6301d2289377fb5
Autor:
Ali Ebrahim, Tadeo Moreno-Chicano, Martin V. Appleby, Amanda K. Chaplin, John H. Beale, Darren A. Sherrell, Helen M. E. Duyvesteyn, Shigeki Owada, Kensuke Tono, Hiroshi Sugimoto, Richard W. Strange, Jonathan A. R. Worrall, Danny Axford, Robin L. Owen, Michael A. Hough
Publikováno v:
IUCrJ, Vol 6, Iss 4, Pp 543-551 (2019)
An approach is demonstrated to obtain, in a sample- and time-efficient manner, multiple dose-resolved crystal structures from room-temperature protein microcrystals using identical fixed-target supports at both synchrotrons and X-ray free-electron la
Externí odkaz:
https://doaj.org/article/d85919f46169431f8075520a1390d09b
Autor:
Marina Lučić, Michael T. Wilson, Takehiko Tosha, Hiroshi Sugimoto, Anastasya Shilova, Danny Axford, Robin L. Owen, Michael A. Hough, Jonathan A. R. Worrall
Publikováno v:
ACS Catalysis. 12:13349-13359
Controlling the reactivity of high-valent Fe(IV)-O catalytic intermediates, Compounds I and II, generated in heme enzymes upon reaction with dioxygen or hydrogen peroxide, is important for function. It has been hypothesized that the presence (wet) or
Autor:
Demet Kekilli, Tadeo Moreno-Chicano, Amanda K. Chaplin, Sam Horrell, Florian S. N. Dworkowski, Jonathan A. R. Worrall, Richard W. Strange, Michael A. Hough
Publikováno v:
IUCrJ, Vol 4, Iss 3, Pp 263-270 (2017)
Powerful synergies are available from the combination of multiple methods to study proteins in the crystalline form. Spectroscopies which probe the same region of the crystal from which X-ray crystal structures are determined can give insights into r
Externí odkaz:
https://doaj.org/article/8b2bf4548c0b4d05886fcd59e4cd3373
Autor:
Dimitri A. Svistunenko, Jonathan A. R. Worrall, Michael T. Wilson, Robin L. Owen, Marina Lučić, Michael A. Hough
Publikováno v:
Journal of Biological Inorganic Chemistry
Structure determination of proteins and enzymes by X-ray crystallography remains the most widely used approach to complement functional and mechanistic studies. Capturing the structures of intact redox states in metalloenzymes is critical for assigni
Autor:
George R. Worrall, Jasmeet Judge
Publikováno v:
IGARSS 2022 - 2022 IEEE International Geoscience and Remote Sensing Symposium.
Autor:
Jonathan A. R. Worrall
Publikováno v:
Encyclopedia of Inorganic and Bioinorganic Chemistry
The ability of copper to cycle between two redox states (CuI/CuII), each having a preference for either soft or hard ligands, gives rise to a diverse spectrum of coordination spheres within protein scaffolds that results in a broad range of functiona