Zobrazeno 1 - 10
of 323
pro vyhledávání: '"R. Woodford"'
Autor:
R. Woodford, S. Luo, E. Ignatova, A. Cammarota, J. Choy, R. Grochot, A. Williams, T. Arkenau, E. Fontana
Publikováno v:
ESMO Gastrointestinal Oncology, Vol 4, Iss , Pp 100054- (2024)
Background: Metastatic colorectal cancer (CRC) is associated with poor overall survival (OS) and limited activity of approved therapeutics following two standard lines of chemotherapy. Participation in phase I trials could offer an alternative treatm
Externí odkaz:
https://doaj.org/article/b449dada2a794ead9330b495461ec502
Autor:
Rebecca A. Sager, Farzana Khan, Lorenzo Toneatto, SarahBeth D. Votra, Sarah J. Backe, Mark R. Woodford, Mehdi Mollapour, Dimitra Bourboulia
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The molecular chaperone Heat Shock Protein-90 (Hsp90) is known to interact with over 300 client proteins as well as regulatory factors (eg. nucleotide and proteins) that facilitate execution of its role as a chaperone and, ultimately, client protein
Externí odkaz:
https://doaj.org/article/6e665a91972e47c9bdf7bdf90d269459
Autor:
Sarah J. Backe, Rebecca A. Sager, Katherine A. Meluni, Mark R. Woodford, Dimitra Bourboulia, Mehdi Mollapour
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 928 (2022)
Heat shock protein-90 (Hsp90) is an ATP-dependent molecular chaperone that is tightly regulated by a group of proteins termed co-chaperones. This chaperone system is essential for the stabilization and activation of many key signaling proteins. Recen
Externí odkaz:
https://doaj.org/article/318844d88a05455f8a84a8a3e70f9abe
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 786 (2022)
Mitochondrial function is dependent on molecular chaperones, primarily due to their necessity in the formation of respiratory complexes and clearance of misfolded proteins. Heat shock proteins (Hsps) are a subset of molecular chaperones that function
Externí odkaz:
https://doaj.org/article/5d47277248ea418dae3ad6a40be19fdb
Autor:
Drew Burchell, Todd Coleman, Robb Travers, Isabella Aversa, Emily Schmid, Simon Coulombe, Ciann Wilson, Michael R. Woodford, Charlie Davis
Publikováno v:
Culture, Health & Sexuality. :1-16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7da3d221728cf2af9d085fd93abbfe51
https://doi.org/10.1080/13691058.2023.2185685
https://doi.org/10.1080/13691058.2023.2185685
Autor:
Karina Tassiopoulos, Robb Travers, Ruth Cameron, Simon Coulombe, Charlie E. Davis, Ciann L. Wilson, Michael R. Woodford, Todd Coleman
Publikováno v:
The Canadian Journal of Human Sexuality. 31:397-408
Gay, bisexual, and other men who have sex with men (GBMSM) remain most disproportionately affected by HIV in Canada. HIV- related sexual risk behaviours have been linked to high HIV risk among GBMSM, but prior research has not focused on knowledge of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2036c49a56b108dcf2e9a6d358b200ab
https://doi.org/10.3138/cjhs.2021-0054
https://doi.org/10.3138/cjhs.2021-0054
Autor:
Javier Sánchez-Pozo, Alexander J. Baker-Williams, Mark R. Woodford, Renee Bullard, Beiyang Wei, Mehdi Mollapour, William G. Stetler-Stevenson, Gennady Bratslavsky, Dimitra Bourboulia
Publikováno v:
iScience, Vol 1, Iss , Pp 87-96 (2018)
Summary: The tissue inhibitor of metalloproteinases 2 (TIMP-2) is a specific endogenous inhibitor of matrix metalloproteinase 2 (MMP-2), which is a key enzyme that degrades the extracellular matrix and promotes tumor cell invasion. Although the TIMP-
Externí odkaz:
https://doaj.org/article/162e0a659f004ddc931c533bf3fe8b79
Autor:
Natela Dushukyan, Diana M. Dunn, Rebecca A. Sager, Mark R. Woodford, David R. Loiselle, Michael Daneshvar, Alexander J. Baker-Williams, John D. Chisholm, Andrew W. Truman, Cara K. Vaughan, Timothy A. Haystead, Gennady Bratslavsky, Dimitra Bourboulia, Mehdi Mollapour
Publikováno v:
Cell Reports, Vol 21, Iss 7, Pp 1883-1895 (2017)
Summary: The serine/threonine protein phosphatase 5 (PP5) regulates multiple cellular signaling networks. A number of cellular factors, including heat shock protein 90 (Hsp90), promote the activation of PP5. However, it is unclear whether post-transl
Externí odkaz:
https://doaj.org/article/1fd7653e1f7244c682e707f46ef9dd06
Publikováno v:
Transgender Health. 7:323-328
Transgender individuals face barriers to accessing gender-affirming hormone therapy, yet little is known about gynecological providers' willingness to provide such care.We surveyed gynecological providers in one healthcare system to determine their w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc65cf29862005df9e07220204d72d69
https://doi.org/10.1089/trgh.2021.0008
https://doi.org/10.1089/trgh.2021.0008
Autor:
Alexander J. Baker-Williams, Fiza Hashmi, Marek A. Budzyński, Mark R. Woodford, Stephanie Gleicher, Samu V. Himanen, Alan M. Makedon, Derek Friedman, Stephanie Cortes, Sara Namek, William G. Stetler-Stevenson, Gennady Bratslavsky, Alaji Bah, Mehdi Mollapour, Lea Sistonen, Dimitra Bourboulia
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1894-1906.e6 (2019)
Summary: The extracellular molecular chaperone heat shock protein 90 (eHSP90) stabilizes protease client the matrix metalloproteinase 2 (MMP2), leading to tumor cell invasion. Although co-chaperones are critical modulators of intracellular HSP90:clie
Externí odkaz:
https://doaj.org/article/5c2fb5f7bb824f3faae72044a1736056