Zobrazeno 1 - 10
of 761
pro vyhledávání: '"R. Witmer"'
Autor:
Jordan R. Witmer, Bailey J. Wetherell, Brett A. Wagner, Juan Du, Joseph J. Cullen, Garry R. Buettner
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 298-304 (2016)
Background: Supra-physiological concentrations of ascorbate, vitamin C, in blood, greater than 1 mM, achieved through intravenous administration (IV), are being tested in clinical trials to treat human disease, e.g. cancer. These trials need informat
Externí odkaz:
https://doaj.org/article/97716d5c13a24cb8b9524ba7c142bc04
Publikováno v:
Redox Biology, Vol 1, Iss 1, Pp 210-217 (2013)
Cells have a wide range of capacities to remove extracellular hydrogen peroxide. At higher concentrations of extracellular H2O2 (micromolar) the rate of removal can be approximated by a rate equation that is first-order in the concentration of H2O2 a
Externí odkaz:
https://doaj.org/article/a57ccba94d6440dbb7c35cd52cb1e052
Akademický článek
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Autor:
Matt Soars, Lisa M. Kopcho, Carolyn A. Weigelt, Shilpa Demes, Gregory D. Vite, Mary J. Harner, Rohit Malik, Guo Li, David G. Harden, Charles F. Voliva, Kevin O’Malley, Zheming Ruan, Lan-Ying Qin, Brian J. Arey, Peter K. Park, Jennifer Price, Steven Sheriff, Gerald J. Duke, Ashvinikumar V. Gavai, JIngjing Deng, Brian E. Fink, Christopher M. Barbieri, Max Ruzanov, Muge Celiktas, Mark R. Witmer, Yuval Blat, William D. Schmitz, Joseph G. Naglich, Iyoncy Rodrigo
Publikováno v:
Cancer Research. 81:1140-1140
The chromosome 9p21 (chr9p21) locus is deleted in almost 10% of all cancer types. This locus includes the CDKN2A gene that encodes the critical tumor suppressors p19-ARF and p16-INK4a. Methylthioadenosine phosphorylase (MTAP), a gene proximal to CDKN
Autor:
William J. Metzler, Luciano Mueller, Yaqun Zhang, Mian Gao, Nicolas Szapiel, Mark R. Witmer, David Hedin, Deepa Calambur, Dianlin Xie, Hui Wei, Frank Marsilio, Andrew E Douglas, Ping Zhang
Publikováno v:
Journal of Biomolecular NMR. 68:237-247
An improved expression protocol is proposed for amino acid type-specific [13C], [15N]-isotope labeling of proteins in baculovirus-infected (BV) insect cell cultures. This new protocol modifies the methods published by Gossert et al. (J Biomol NMR 51(
Autor:
Katherine A. Grant-Young, Andrew Nickel, Rajesh Onkardas Bora, Prakash Anjanappa, Bender John A, Kevin Kish, Kap-Sun Yeung, Dawn D. Parker, Joseph Raybon, Mark R. Witmer, Karen Rigat, Matthew G. Soars, Steven Sheriff, Yue-Zhong Shu, Kenneth S. Santone, Prashantha Gunaga, Kyle Parcella, Nicholas A. Meanwell, Jay O. Knipe, Susan B. Roberts, Alicia Ng, Michael Sinz, Kathy Mosure, Ying-Kai Wang, Brett R. Beno, Mengping Liu, Elizabeth Colston, Dennis M. Grasela, John F. Kadow, Qi Gao, Min Gao, Umesh Hanumegowda, Roy Haskell, Julie A. Lemm, Xiaoliang Zhuo, Changhong Wan, Kumaravel Selvakumar
Publikováno v:
Journal of Medicinal Chemistry. 60:4369-4385
The hepatitis C virus (HCV) NS5B replicase is a prime target for the development of direct-acting antiviral drugs for the treatment of chronic HCV infection. Inspired by the overlay of bound structures of three structurally distinct NS5B palm site al
Autor:
Hua Fang, Kevin Kish, Mark R. Witmer, Matthew G. Soars, Kyle Parcella, Brett R. Beno, Ying-Kai Wang, Prakash Anjanappa, Julie A. Lemm, Karen Rigat, Katherine A. Grant-Young, Kap-Sun Yeung, Kathy Mosure, Steven Sheriff, Kenneth S. Santone, Jeffrey Tredup, Dawn D. Parker, John F. Kadow, Rajesh Onkardas Bora, Mengping Liu, Nicholas A. Meanwell, Susan B. Roberts, Adam G. Jardel, Rudolph G. Krause, Juliang Zhu, Kumaravel Selvakumar, Roy Haskell
[Image: see text] In solving the P-gp and BCRP transporter-mediated efflux issue in a series of benzofuran-derived pan-genotypic palm site inhibitors of the hepatitis C virus NS5B replicase, it was found that close attention to physicochemical proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b87c17f58394ad90d7b8ea7bef1817f
https://europepmc.org/articles/PMC6295864/
https://europepmc.org/articles/PMC6295864/
Autor:
Kaitlyn Dubishar, Jordan R Witmer, Lauren J Points, Janie Myers, Lyndsey E. DuBose, Gary L. Pierce, Kyle Siefers, Catherine A. Chenard, Abbi D. Lane-Cordova
Publikováno v:
Vascular Medicine. 21:429-436
A diet high in trans-fatty acids (TFAs) is associated with a higher risk of cardiovascular disease (CVD) than a diet high in saturated fatty acids (SFAs), but the mechanisms remain unclear. We hypothesized that a beverage high in TFAs would cause a l
Autor:
Stephen R. Johnson, Dianlin Xie, Lihong Cheng, Yang Hong, John S. Tokarski, Adriana Zupa-Fernandez, Jodi K. Muckelbauer, Mark R. Witmer, Sophie Wu, Chiehying Chang, Donna L. Pedicord, Suzanne C. Edavettal, David S. Weinstein, William J. Pitts, Yuval Blat, James R. Burke, Lisa Elkin, Kristen Pike, Jeffrey Tredup
Publikováno v:
Journal of Biological Chemistry. 290:11061-11074
Inhibition of signal transduction downstream of the IL-23 receptor represents an intriguing approach to the treatment of autoimmunity. Using a chemogenomics approach marrying kinome-wide inhibitory profiles of a compound library with the cellular act
Autor:
Joseph E. Myers, Javed Khan, Daniel Meyers, Ginger Chao, Doree F. Sitkoff, Fred Lo, Katie A. Russo, Hossain Monshizadegan, Tracy S. Mitchell, Mark R. Witmer, Rex A. Parker, Bowman Miao, Mian Gao, Denhez Fabienne M, Gerald J. Duke, Dibella Rose A, Simon Low, Siew Peng Ho
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 350:412-424
Proprotein convertase subtilisin kexin-9 (PCSK9) is an important pharmacological target for decreasing low-density lipoprotein (LDL) in cardiovascular disease, although seemingly inaccessible to small molecule approaches. Compared with therapeutic Ig