Zobrazeno 1 - 10
of 93
pro vyhledávání: '"R. William Caldwell"'
Autor:
Abdelrahman Y. Fouda, Zhimin Xu, Jutamas Suwanpradid, Modesto Rojas, Esraa Shosha, Tahira Lemtalsi, Chintan Patel, Ji Xing, Syed A. Zaidi, Wenbo Zhi, Brain K. Stansfield, Paul Ning-Man Cheng, S. Priya Narayanan, R. William Caldwell, Ruth B. Caldwell
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-12 (2022)
Abstract Current therapies for treatment of proliferative retinopathy focus on retinal neovascularization (RNV) during advanced disease and can trigger adverse side-effects. Here, we have tested a new strategy for limiting neurovascular injury and pr
Externí odkaz:
https://doaj.org/article/9425c35153c5408eae0768802d3f931a
Publikováno v:
Cells, Vol 12, Iss 5, p 795 (2023)
Advanced glycation end products (AGEs) contribute significantly to vascular dysfunction (VD) in diabetes. Decreased nitric oxide (NO) is a hallmark in VD. In endothelial cells, NO is produced by endothelial NO synthase (eNOS) from L-arginine. Arginas
Externí odkaz:
https://doaj.org/article/ea96d5513ba54d3f8cdd8726c74211f8
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Diabetic retinopathy (DR) and diabetic macular edema (DME) are retinal complications of diabetes that can lead to loss of vision and impaired quality of life. The current gold standard therapies for treatment of DR and DME focus on advanced disease,
Externí odkaz:
https://doaj.org/article/a5ecce87e59449c0a9428bf8aa41fb53
Autor:
Esraa Shosha, Abdelrahman Y. Fouda, Tahira Lemtalsi, Stephen Haigh, David Fulton, Ahmed Ibrahim, Mohamed Al-Shabrawey, R. William Caldwell, Ruth B. Caldwell
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101273- (2021)
Objective: Retinal ischemic disease is a major cause of vision loss. Current treatment options are limited to late-stage diseases, and the molecular mechanisms of the initial insult are not fully understood. We have previously shown that the deletion
Externí odkaz:
https://doaj.org/article/72187996925f42ffb82d739c8a5f3c64
Autor:
Ammar A. Abdelrahman, Katharine L. Bunch, Porsche V. Sandow, Paul N-M Cheng, Ruth B. Caldwell, R. William Caldwell
Publikováno v:
Cells, Vol 11, Iss 18, p 2890 (2022)
Diabetic retinopathy (DR) is a serious complication of diabetes that results from sustained hyperglycemia, hyperlipidemia, and oxidative stress. Under these conditions, inducible nitric oxide synthase (iNOS) expression is upregulated in the macrophag
Externí odkaz:
https://doaj.org/article/996ca2788c014067a32a8611af4d6be1
Autor:
Abdelrahman Y. Fouda, Wael Eldahshan, S. Priya Narayanan, R. William Caldwell, Ruth B. Caldwell
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Ischemic retinopathies represent a major cause of visual impairment and blindness. They include diabetic retinopathy (DR), acute glaucoma, retinopathy of prematurity (ROP), and central (or branch) retinal artery occlusion (CRAO). These conditions sha
Externí odkaz:
https://doaj.org/article/498efde81b864c29aa0c6bf98cfd1b7e
Autor:
Kumar Subramani, Sumin Lu, Marie Warren, Xiaogang Chu, Haroldo A. Toque, R. William Caldwell, Michael P. Diamond, Raghavan Raju
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Hemorrhagic shock is a leading cause of death in people under the age of 45 and accounts for almost half of trauma-related deaths. In order to develop a treatment strategy based on potentiating mitochondrial function, we investigated the eff
Externí odkaz:
https://doaj.org/article/e822436faae34deb91a963d3534179b2
Autor:
Zhimin Xu, Abdelrahman Y. Fouda, Tahira Lemtalsi, Esraa Shosha, Modesto Rojas, Fang Liu, Chintan Patel, R. William Caldwell, Subhadra Priya Narayanan, Ruth B. Caldwell
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Our previous studies have implicated expression of the mitochondrial isoform of the arginase enzyme arginase 2 (A2) in neurovascular injury during ischemic retinopathies. The aim of this study was to characterize the specific involvement of A2 in ret
Externí odkaz:
https://doaj.org/article/3ba55fe49f214d8f8b5800625616fdda
Autor:
Haroldo A. Toque, Kenia P. Nunes, Modesto eRojas, Anil eBhatta, Lin eYao, Zhimin eXu, Maritza J. Romero, R. Clinton Webb, Ruth B. Caldwell, R. William Caldwell
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Enhanced arginase (ARG) activity has been identified as a factor that reduces nitric oxide (NO) production and impairs endothelial function in vascular pathologies. Using a gene deletion model, we investigated involvement of arginase isoforms (1 and
Externí odkaz:
https://doaj.org/article/85d3ce4420e9451facce6daa184b8258
Autor:
Ammar A. Abdelrahman, Wael Eldahshan, R. William Caldwell, Zhimin Xu, Paul Ning-Man Cheng, Syed Ah. Zaidi, Abdelrahman Y. Fouda, Tahira Lemtalsi, Esraa Shosha, Ruth B. Caldwell, S. Priya Narayanan
Publikováno v:
Exp Neurol
Arginase 1 (A1) is the enzyme that hydrolyzes the amino acid, L-arginine, to ornithine and urea. We have previously shown that A1 deletion worsens retinal ischemic injury, suggesting a protective role of A1. In this translational study, we aimed to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56559a73ba7f7b60382a7ee3564fff6d
https://europepmc.org/articles/PMC9122100/
https://europepmc.org/articles/PMC9122100/
