Zobrazeno 1 - 10
of 839
pro vyhledávání: '"R. Whittemore"'
Autor:
Paula M. Chilton, Smita S. Ghare, Benjamin T. Charpentier, Scott A. Myers, Aakarsha V. Rao, Joseph F. Petrosino, Kristi L. Hoffman, John C. Greenwell, Neetu Tyagi, Jyotirmaya Behera, Yali Wang, Lucy J. Sloan, JingWen Zhang, Christopher B. Shields, Gregory E. Cooper, Leila Gobejishvili, Scott R. Whittemore, Craig J. McClain, Shirish S. Barve
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Alterations in the gut-microbiome-brain axis are increasingly being recognized to be involved in Alzheimer’s disease (AD) pathogenesis. However, the functional consequences of enteric dysbiosis linking gut microbiota and brain pathology in AD progr
Externí odkaz:
https://doaj.org/article/68fececdccb84cc983088b9ee897f11c
Autor:
Michael D. Forston, George Z. Wei, Julia H. Chariker, Tyler Stephenson, Kariena Andres, Charles Glover, Eric C. Rouchka, Scott R. Whittemore, Michal Hetman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Reducing the loss of oligodendrocytes (OLs) is a major goal for neuroprotection after spinal cord injury (SCI). Therefore, the OL translatome was determined in Ribotag:Plp1-CreERT2 mice at 2, 10, and 42 days after moderate contusive T9 SCI.
Externí odkaz:
https://doaj.org/article/25b672294eec4bd998b6a7d833bbd313
Autor:
Yonglin Gao, George Z. Wei, Michael D. Forston, Benjamin Rood, Emily R. Hodges, Darlene Burke, Kariena Andres, Johnny Morehouse, Christine Armstrong, Charles Glover, Lukasz P. Slomnicki, Jixiang Ding, Julia H. Chariker, Eric C. Rouchka, Sujata Saraswat Ohri, Scott R. Whittemore, Michal Hetman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The integrated stress response (ISR)-activated transcription factors ATF4 and CHOP/DDIT3 may regulate oligodendrocyte (OL) survival, tissue damage and functional impairment/recovery in white matter pathologies, including traumatic spinal cor
Externí odkaz:
https://doaj.org/article/c62c1950456b4036b0d7c1fda06c3c7f
Autor:
Courtney T Shepard, Brandon L Brown, Morgan A Van Rijswijck, Rachel M Zalla, Darlene A Burke, Johnny R Morehouse, Amberly S Riegler, Scott R Whittemore, David SK Magnuson
Publikováno v:
eLife, Vol 12 (2023)
Spinal locomotor circuitry is comprised of rhythm generating centers, one for each limb, that are interconnected by local and long-distance propriospinal neurons thought to carry temporal information necessary for interlimb coordination and gait cont
Externí odkaz:
https://doaj.org/article/2fe9eeda317740ffa74b222679cc71bc
Autor:
Courtney T Shepard, Amanda M Pocratsky, Brandon L Brown, Morgan A Van Rijswijck, Rachel M Zalla, Darlene A Burke, Johnny R Morehouse, Amberley S Riegler, Scott R Whittemore, David SK Magnuson
Publikováno v:
eLife, Vol 10 (2021)
Long ascending propriospinal neurons (LAPNs) are a subpopulation of spinal cord interneurons that directly connect the lumbar and cervical enlargements. Previously we showed, in uninjured animals, that conditionally silencing LAPNs disrupted left-rig
Externí odkaz:
https://doaj.org/article/76d9111e10d94c34bf93f809c60aae3d
Publikováno v:
Cells, Vol 11, Iss 21, p 3339 (2022)
Proteostasis (protein homeostasis) is critical for cellular as well as organismal survival. It is strictly regulated by multiple conserved pathways including the ubiquitin-proteasome system, autophagy, the heat shock response, the integrated stress r
Externí odkaz:
https://doaj.org/article/f8e5ad9ea58047d3aa13911107897c25
Autor:
Scott A. Myers, Leila Gobejishvili, Sujata Saraswat Ohri, C. Garrett Wilson, Kariena R. Andres, Amberly S. Riegler, Hridgandh Donde, Swati Joshi-Barve, Shirish Barve, Scott R. Whittemore
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 353-363 (2019)
Emerging evidence links changes in the gut microbiome and intestinal barrier function to alterations in CNS function. We examined the role of endotoxin-responsive, cAMP-specific, Pde4 subfamily b (Pde4b) enzyme in gut dysbiosis induced neuro-inflamma
Externí odkaz:
https://doaj.org/article/5aac30fa5f7f4eeca98245bdc289a49d
Autor:
Sujata Saraswat Ohri, Kariena R. Andres, Russell M. Howard, Brandon L. Brown, Michael D. Forston, Michal Hetman, Scott R. Whittemore
Publikováno v:
Journal of Neurotrauma. 40:1007-1019
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c916c316425de9bde733219201e2184c
https://doi.org/10.1089/neu.2022.0177
https://doi.org/10.1089/neu.2022.0177
Autor:
Brandon L. Brown, Rachel M. Zalla, Courtney T. Shepard, Russell M. Howard, Jonathan A. Kopechek, David S. K. Magnuson, Scott R. Whittemore
Publikováno v:
Frontiers in Neuroanatomy, Vol 15 (2021)
The nervous system coordinates pathways and circuits to process sensory information and govern motor behaviors. Mapping these pathways is important to further understand the connectivity throughout the nervous system and is vital for developing treat
Externí odkaz:
https://doaj.org/article/cd7e30e544d84b4bac341798df207e48
Autor:
George Z Wei, Sujata Saraswat Ohri, Nicolas K Khattar, Adam W Listerman, Catherine H Doyle, Kariena R Andres, Saravanan S Karuppagounder, Rajiv R Ratan, Scott R Whittemore, Michal Hetman
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249591 (2021)
Traumatic spinal cord injury (SCI) is a devastating neurological condition that involves both primary and secondary tissue loss. Various cytotoxic events including hypoxia, hemorrhage and blood lysis, bioenergetic failure, oxidative stress, endoplasm
Externí odkaz:
https://doaj.org/article/afcf059cd1dc42a1bcc67fbc7242ecef