Zobrazeno 1 - 10
of 129
pro vyhledávání: '"R. Wayne Alexander"'
Publikováno v:
Cell Reports, Vol 12, Iss 9, Pp 1391-1399 (2015)
Cellular senescence and organismal aging predispose age-related chronic diseases, such as neurodegenerative, metabolic, and cardiovascular disorders. These diseases emerge coincidently from elevated oxidative/electrophilic stress, inflammation, mitoc
Externí odkaz:
https://doaj.org/article/cfac55d2aaa64f0fa6e8503656630a29
Autor:
Ibhar Al Mheid, Heval Mohamed Kelli, Yi‐An Ko, Muhammad Hammadah, Hina Ahmed, Salim Hayek, Viola Vaccarino, Thomas R. Ziegler, Greg Gibson, Michelle Lampl, R. Wayne Alexander, Ken Brigham, Greg S. Martin, Arshed A. Quyyumi
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 10 (2016)
BackgroundLifestyle modifications are first‐line measures for cardiovascular disease prevention. Whether lifestyle intervention also preserves cardiovascular health is less clear. Our study examined the role of a Health Partner–administered lifes
Externí odkaz:
https://doaj.org/article/45d82dcd5e5f40ffa7e330fcc654ce57
Publikováno v:
Cell Reports, Vol 12, Iss 9, Pp 1391-1399 (2015)
SummaryCellular senescence and organismal aging predispose age-related chronic diseases, such as neurodegenerative, metabolic, and cardiovascular disorders. These diseases emerge coincidently from elevated oxidative/electrophilic stress, inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffc00f1874a2c7f33073cb8ce29be65
https://doi.org/10.1016/j.celrep.2015.07.047
https://doi.org/10.1016/j.celrep.2015.07.047
Autor:
Hina Ahmed, Ibhar Al Mheid, Heval M. Kelli, Greg S. Martin, Viola Vaccarino, Muhammad Hammadah, Arshed A. Quyyumi, Thomas R. Ziegler, Yi-An Ko, R. Wayne Alexander, Greg Gibson, Michelle Lampl, Salim S. Hayek, Ken Brigham
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Lifestyle modifications are first‐line measures for cardiovascular disease prevention. Whether lifestyle intervention also preserves cardiovascular health is less clear. Our study examined the role of a Health Partner–administered life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b73c94a0247e6b6af0a734acf99837b
https://doi.org/10.1161/jaha.116.004217
https://doi.org/10.1161/jaha.116.004217
Autor:
Lula Hilenski, Gloria Salazar, Nikolay Patrushev, Shiqin Xiong, R. Wayne Alexander, Alejandra San Martin, Rafal R. Nazarewicz
Publikováno v:
Journal of Biological Chemistry. 286:2886-2895
Akt/protein kinase B (PKB) activation/phosphorylation by angiotensin II (Ang II) is a critical signaling event in hypertrophy of vascular smooth muscle cells (VSMCs). Conventional wisdom asserts that Akt activation occurs mainly in plasma membrane do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27629a39a933085e7cb13e1009ef21d
https://doi.org/10.1074/jbc.m110.141499
https://doi.org/10.1074/jbc.m110.141499
Autor:
Bing Wang, Seoung Bum Kim, Thomas R. Ziegler, Ngoc-Anh Le, R. Wayne Alexander, Carolyn Jonas Accardi, Roberto A. Blanco, Youngja Park, Shaoxiong Wu, Dean P. Jones
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 297:R202-R209
Proton nuclear magnetic resonance (1H-NMR) spectroscopy of plasma provides a global metabolic profiling method that shows promise for clinical diagnostics. However, cross-sectional studies are complicated by a lack of understanding of intraindividual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe7061d927d691fb42b81ecf5aee151
https://doi.org/10.1152/ajpregu.90757.2008
https://doi.org/10.1152/ajpregu.90757.2008
Autor:
R. Wayne Alexander, Raymond J. Gibbons, Robert A. Kloner, Allan M. Ross, Gregg W. Stone, Mervyn B. Forman
Publikováno v:
European Heart Journal. 27:2400-2405
Aims The purpose of this analysis was to determine whether the efficacy of adenosine vs. placebo was dependent on the timing of reperfusion therapy in the second Acute Myocardial Infarction Study of Adenosine (AMISTAD-II). Methods and results Patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb194c37a320c0243e715e5aaea3a741
https://doi.org/10.1093/eurheartj/ehl094
https://doi.org/10.1093/eurheartj/ehl094
Autor:
Lian Zuo, Satoshi Ikeda, R. Wayne Alexander, Masuko Ushio-Fukai, Nikolay Patrushev, Lula Hilenski
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 25:1824-1830
Objective— Angiotensin II (Ang II) is a potent mediator of vascular hypertrophy in vascular smooth muscle cells (VSMCs). These effects are mediated through the Ang II type 1 receptor (AT 1 R) and require its trafficking through caveolin-1 (Cav1)–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7e22d89ca85827b81cc99deaaa1403
https://doi.org/10.1161/01.atv.0000175295.09607.18
https://doi.org/10.1161/01.atv.0000175295.09607.18
Publikováno v:
Journal of the American College of Cardiology. 45:1775-1780
ObjectivesThe purpose of this research was to determine the effect of intravenous adenosine on clinical outcomes and infarct size in ST-segment elevation myocardial infarction (STEMI) patients undergoing reperfusion therapy.BackgroundPrevious small s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3139118fc1a45f025c52c4b5cda4c8e
https://doi.org/10.1016/j.jacc.2005.02.061
https://doi.org/10.1016/j.jacc.2005.02.061
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 25:1142-1147
Objective— Angiotensin II has been implicated in the pathogenesis of the vascular complications of insulin resistance. Recently, serine phosphorylation and degradation of insulin receptor substrate-1 (IRS-1) were shown to inhibit Akt activation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f24d77a655b5a52ca2610f27ed39614
https://doi.org/10.1161/01.atv.0000164313.17167.df
https://doi.org/10.1161/01.atv.0000164313.17167.df