Zobrazeno 1 - 10 of 189 pro vyhledávání: '"R. Wakeman"'
1
Akademický článek
Mitomycin‐C treatment during differentiation of induced pluripotent stem cell‐derived dopamine neurons reduces proliferation without compromising survival or function in vivo
Autor: Benjamin M. Hiller, David J. Marmion, Rachel M. Gross, Cayla A. Thompson, Carrie A. Chavez, Patrik Brundin, Dustin R. Wakeman, Christopher W. McMahon, Jeffrey H. Kordower
Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 2, Pp 278-290 (2021)
Abstract Nongenetic methodologies to reduce undesirable proliferation would be valuable when generating dopamine neurons from stem cells for transplantation in Parkinson's disease (PD). To this end, we modified an established method for controlled di
Externí odkaz: https://doaj.org/article/f01fe3c0dbb64c11a6b43d6f7c6c3c41
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3
Akademický článek
Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo
Autor: Dustin R. Wakeman, Benjamin M. Hiller, David J. Marmion, Christopher W. McMahon, Grant T. Corbett, Kile P. Mangan, Junyi Ma, Lauren E. Little, Zhong Xie, Tamara Perez-Rosello, Jaime N. Guzman, D. James Surmeier, Jeffrey H. Kordower
Publikováno v: Stem Cell Reports, Vol 9, Iss 1, Pp 149-161 (2017)
A major challenge for clinical application of pluripotent stem cell therapy for Parkinson's disease (PD) is large-scale manufacturing and cryopreservation of neurons that can be efficiently prepared with minimal manipulation. To address this obstacle
Externí odkaz: https://doaj.org/article/0af637ef3a9f474e93fae6c09d34903c
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5
Akademický článek
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6
P670 'What Matters To You?' – How do patient views compare with a patient experience framework and UK national standards of care?
Autor: E Sheldon, S Roman, K Randall, H Rachel, G Winsor, R Wakeman, A Lobo
Publikováno v: Journal of Crohn's and Colitis. 17:i801-i802
Background There is increasing focus on the organisation of services for people with IBD. Patient experience of care is an important consideration in service delivery. The United Kingdom NHS Long Term Plan indicates the importance of support that is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1faf6fe1b9cad82497c8b5e9955c86f7
https://doi.org/10.1093/ecco-jcc/jjac190.0800
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7
P284 Assessing Patient Experience in an Inflammatory Bowel Disease service. Can we measure an effect from socioeconomic deprivation – experience from the AWARE-IBD programme?
Autor: E Sheldon, S Roman, M Bursnall, R Hawkins, A Lobo, D Hind, K Randall, R Wakeman, R Ainley
Publikováno v: Journal of Crohn's and Colitis. 17:i431-i432
Background There is increasing international attention on delivery of services for people with Inflammatory bowel diseases (IBD). Experience of care is defined and measured as ‘what’ happened, ‘how’ and ‘how often’ and is an important fac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8dac2949b66a3db320892fb4c3bbea3
https://doi.org/10.1093/ecco-jcc/jjac190.0414
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8
Mitomycin‐C treatment during differentiation of induced pluripotent stem cell‐derived dopamine neurons reduces proliferation without compromising survival or function in vivo
Autor: Rachel M. Gross, David J. Marmion, Patrik Brundin, Christopher W. McMahon, Cayla A. Thompson, Jeffrey H. Kordower, Benjamin M. Hiller, Carrie Chavez, Dustin R. Wakeman
Publikováno v: Stem Cells Translational Medicine
Stem Cells Translational Medicine, Vol 10, Iss 2, Pp 278-290 (2021)
Nongenetic methodologies to reduce undesirable proliferation would be valuable when generating dopamine neurons from stem cells for transplantation in Parkinson's disease (PD). To this end, we modified an established method for controlled differentia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0eeb429b18d071b4402413e0eb17e9
http://europepmc.org/articles/PMC7848297
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9
Intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease
Autor: Dustin R. Wakeman, Michael R. Weed, Sylvia E. Perez, Erika N. Cline, Kirsten L. Viola, Kyle C. Wilcox, David S. Moddrelle, Ernell Z. Nisbett, Anish M. Kurian, Amanda F. Bell, Ricaldo Pike, Peer B. Jacobson, William L. Klein, Elliott J. Mufson, Matthew S. Lawrence, John D. Elsworth
Publikováno v: Neuropathology and applied neurobiologyREFERENCES. 48(4)
An obstacle to developing new treatment strategies for Alzheimer's disease (AD) has been the inadequate translation of findings in current AD transgenic rodent models to the prediction of clinical outcomes. By contrast, nonhuman primates (NHPs) share
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e008c988d7d44fd1dd22787c703de9e0
https://pubmed.ncbi.nlm.nih.gov/35156715
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10
P102 Psychosocial themes of the impact of the COVID-19 pandemic and shielding in adults and children with early-onset neuromuscular disorders and their families
Autor: R. Wakeman, A. Simonds, L. Spurr, Hui-Leng Tan, Michelle Chatwin
Publikováno v: The wider impact of the pandemic.
IntroductionMost patients with early-onset neuromuscular disorders (NMDs) were advised to shield during the pandemic due to assumptions that treatments e.g. corticosteroids, or complications e.g. pre-existing respiratory failure would increase COVID-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ef0a6c469b525e20269667bcad8667f
https://doi.org/10.1136/thorax-2021-btsabstracts.211
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