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Elektronická kniha

Autor: Elizabeth A. Mannix, Margaret Ann Neale, Cameron Anderson, R. Wageman

Affective phenomena permeate group life. When individuals work together in groups, feelings of pride, fear, hope, anger, and anxiety constantly emerge and have a profound influence on group member behavior. The experience and expression of moods and

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Akademický článek

TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors

Autor: Teagan R. Wall, Brandon J. Henderson, George Voren, Charles R. Wageman, Purnima Deshpande, Bruce N. Cohen, Sharon R. Grady, Michael J. Marks, Daniel Yohannes, Paul J. Kenny, Merouane Bencherif, Henry A. Lester

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2∗ (α6β2-containing), α4β2∗, and α3β4∗ nAChRs, usin

Externí odkaz: https://doaj.org/article/fe16dc1017fe4cafa3021cac90dfb168

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Akademický článek

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

Autor: Rell L Parker, Heidi C O'Neill, Beverley M Henley, Charles R Wageman, Ryan M Drenan, Michael J Marks, Julie M Miwa, Sharon R Grady, Henry A Lester

Publikováno v: PLoS ONE, Vol 12, Iss 12, p e0188715 (2017)

The α6 nicotinic acetylcholine receptor (nAChR) subunit is an attractive drug target for treating nicotine addiction because it is present at limited sites in the brain including the reward pathway. Lynx1 modulates several nAChR subtypes; lynx1-nACh

Externí odkaz: https://doaj.org/article/2f56db3f51614a81b5acf01883f73afa

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Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice

Autor: Jordan M. Buck, Charles R. Wageman, Jerry A. Stitzel, Heidi C. O'Neill, Valerie S. Knopik, Kelsey N. Sanders

Publikováno v: Neuropharmacology. 149:66-82

Maternal smoking during pregnancy, a form of developmental nicotine exposure (DNE), is associated with increased nicotine use and neurodevelopmental disorders such as ADHD in children. Here, we characterize the behavioral, rhythmometric, neuropharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d11297317e5d7c018bad77fc15a944
https://doi.org/10.1016/j.neuropharm.2019.02.006

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Synthesis, Nicotinic Acetylcholine Binding, and in Vitro and in Vivo Pharmacological Properties of 2′-Fluoro-(carbamoylpyridinyl)deschloroepibatidine Analogues

Autor: Pauline W. Ondachi, Hernán A. Navarro, Charles W. Luetje, Michael J. Marks, F. Ivy Carroll, Charles R. Wageman, Ana H. Castro, S. Wayne Mascarella, M. Imad Damaj

Publikováno v: ACS Chemical Neuroscience. 7:1004-1012

In this study, we report the synthesis, nAChR in vitro and in vivo pharmacological properties of 2'-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogues (5, 6a,b, and 7a,b), which are analogues of our lead structure epibatidine. All of the analo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe43f8609503049b3b626729bfffc35
https://doi.org/10.1021/acschemneuro.6b00107

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In Vitro and in Vivo Neuronal Nicotinic Receptor Properties of (+)- and (−)-Pyrido[3,4]homotropane [(+)- and (−)-PHT]: (+)-PHT Is a Potent and Selective Full Agonist at α6β2 Containing Neuronal Nicotinic Acetylcholine Receptors

Autor: Hernán A. Navarro, Asti Jackson, F. Ivy Carroll, S. Wayne Mascarella, Charles W. Luetje, Charles R. Wageman, M. Imad Damaj, Ana H. Castro, Michael J. Marks

Publikováno v: ACS Chemical Neuroscience. 6:920-926

Pyrido[3,4]homotropane (PHT) is a conformationally rigid, high affinity analogue of nicotine. (+)-PHT was previously shown to be 266 times more potent than (-)-PHT for inhibition of [(3)H]epibatidine binding to nAChRs but had no antinociceptive activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4eab5b69b94adf112ae8dfc2d7c6f81
https://doi.org/10.1021/acschemneuro.5b00077

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Deletion of lynx1 reduces the function of α6* nicotinic receptors

Autor: Julie M. Miwa, Ryan M. Drenan, Rell L. Parker, Michael J. Marks, Beverley M. Henley, Charles R. Wageman, Sharon R. Grady, Henry A. Lester, Heidi C. O'Neill

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0188715 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19659dfc8d0928faafc81c9ea8553f9
https://resolver.caltech.edu/CaltechAUTHORS:20171211-155148787

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The interaction of the Chrna5 D398N variant with developmental nicotine exposure

Autor: Jerry A. Stitzel, Sharon R. Grady, Charles R. Wageman, Heidi C. O'Neill, S. E. Sherman, Michael J. Marks

Publikováno v: Genes Brain Behav

A single nucleotide polymorphism (SNP) in CHRNA5 (rs16969968, change from an aspartic acid [D] to asparagine [N] at position 398 of the human α5 nicotinic acetylcholine receptor subunit) has been associated with increased risk for nicotine dependenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae4793db2839973a4b8b5401351c567
https://pubmed.ncbi.nlm.nih.gov/29573323

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Abstract 4245: Drug response metrics and pharmacological profiling using the OncoPanel™ cell-based profiling service

Autor: Tracy Lu, Vanessa L. Norman, Lee R. Cavedine, Kayla A. Stehle, Steven M. Garner, Natiya E. Robinson, Alyssa M. Croff, Jesse J. Parry, Victoria V. McBain, Kristin C. Dempsey, Joseph T. Murphy, Charles R. Wageman, Brogan A. Epkins, Alastair J. King

Publikováno v: Cancer Research. 79:4245-4245

High-throughput, cell-based drug screening platforms are essential to guiding drug discovery programs and can rapidly generate large amounts of pharmacological information about a candidate drug. Drug response data combined with genomic and phenotypi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b1877cd935a71a2e4979be6b16ca31b
https://doi.org/10.1158/1538-7445.am2019-4245

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Abstract 2073: Profiling and comparison of breast cancer standard of care agents using the OncoPanel™ cell-based profiling service

Autor: Alastair J. King, Natiya E. Robinson, Kayla A. Stehle, Steven M. Garner, Jesse J. Parry, Vanessa L. Norman, Kristin C. Dempsey, Joseph W. Murphy, Charles R. Wageman, Alyssa M. Croff, Lee R. Cavedine, Tracy Lu, Brogan A. Epkins, Victoria V. McBain

Publikováno v: Cancer Research. 79:2073-2073

Oncology drugs with clinical utility for the treatment of breast cancer span a wide range of different mechanisms and cancer type profiles. Anti-cancer therapies have come a long way from the early use of broad spectrum, cytotoxic agents, with mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65da7b56300a4d0b4d38de7f203443bb
https://doi.org/10.1158/1538-7445.am2019-2073

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