Zobrazeno 1 - 10
of 25
pro vyhledávání: '"R. W. Sweet"'
Autor:
P Tsui, M A Tornetta, R S Ames, B C Bankosky, S Griego, C Silverman, T Porter, G Moore, R W Sweet
Publikováno v:
The Journal of Immunology. 157:772-780
We isolated a large panel of human Abs directed against the respiratory syncytial virus (RSV) Ag from combinatorial phage display libraries. Following initial differentiation of the Fabs by BstNI restriction patterns, DNA sequence analysis revealed 1
Publikováno v:
The Journal of Immunology. 147:1470-1476
The T cell surface molecule CD4 (L3T4 in mouse) is important in the T lymphocyte response to Ag presented in association with MHC class II molecules. To examine the role of CD4 in immune function, we expressed a soluble form of murine CD4 by deleting
Autor:
R W Sweet, Danielle Sainty, Françoise Mallet, J-M Schiano de Colella, Régis Costello, Alemseged Truneh, Daniel Olive, B Barbarat
Publikováno v:
Leukemia. 17(12)
Stimulation by CD40 ligand (L) improves B-cell malignancy immunogenicity, and also induces proliferative signals. To avoid these tumorigenic effects, we studied an alternate way of tumor-cell stimulation by homologous to lymphotoxin, inducible expres
Autor:
M L, Doyle, M, Brigham-Burke, M N, Blackburn, I S, Brooks, T M, Smith, R, Newman, M, Reff, W F, Stafford, R W, Sweet, A, Truneh, P, Hensley, D J, O'Shannessy
Publikováno v:
Methods in enzymology. 323
This chapter has described a bioenergetic analysis of the interaction of sCD4 with an IgG1 and two IgG4 derivatives of an anti-sCD4 MAb. The MAbs have identical VH and VL domains but differ markedly in their CH and CL domains, raising the question of
Autor:
P, Tsui, M A, Tornetta, R S, Ames, B C, Bankosky, S, Griego, C, Silverman, T, Porter, G, Moore, R W, Sweet
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 157(2)
We isolated a large panel of human Abs directed against the respiratory syncytial virus (RSV) Ag from combinatorial phage display libraries. Following initial differentiation of the Fabs by BstNI restriction patterns, DNA sequence analysis revealed 1
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 157(1)
CD28 and CTLA-4 are homologue members of the Ig superfamily of molecules, containing a single V-like domain, transmembrane, and cytoplasmic regions. Both receptors associate with the counter-receptors CD80 and CD86, but the avidity of interaction for
Publikováno v:
The Journal of biological chemistry. 267(13)
A lambda phage expression methodology was adapted to dissect protein/ligand interactions efficiently through the creation and rapid screening of large numbers of mutants. Here we describe the method and its specific application to the interaction bet
Autor:
M J, Mulligan, G D, Ritter, M A, Chaikin, G V, Yamshchikov, P, Kumar, B H, Hahn, R W, Sweet, R W, Compans
Publikováno v:
Virology. 187(1)
Utilizing a recombinant vaccinia expression system, we investigated the biological properties and CD4 receptor interactions of the envelope glycoproteins of a noncytopathic human immunodeficiency virus type 2 strain, termed HIV-2/ST, and a highly cyt
Publikováno v:
Journal of neurochemistry. 58(3)
The role of the alpha subunit of the guanine nucleotide-binding regulatory protein that stimulates adenylyl cyclase (GS alpha) in the down-regulation of beta-adrenergic receptors by pindolol was studied in S49 cyc- cells (normally GS alpha-deficient)
Publikováno v:
Molecular pharmacology. 39(6)
The alpha subunit of the guanine nucleotide-binding regulatory protein GS mediates stimulation of adenylyl cyclase activity. This subunit, GS alpha, exists as two molecular weight forms, termed long and short, that differ by 14 or 15 amino acids. A p