Monocyclic Quinone Structure‐Activity Patterns: Synthesis of Catalytic Inhibitors of Topoisomerase II with Potent Antiproliferative Activity

Autor: Thomas M. Waugh, John R. W. Masters, Abil E. Aliev, Charles M. Marson

Publikováno v: ChemMedChem. 15:114-124

The monocyclic 1,4-benzoquinone, HU-331, the direct oxidation product of cannabidiol, inhibits the catalytic activity of topoisomerase II but without inducing DNA strand breaks or generating free radicals, and unlike many fused-ring quinones exhibits

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c812b50f32106427d0da56e455a5d1
https://doi.org/10.1002/cmdc.201900548

Quantitative analysis of BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue.

Autor: Andrew J Symes, Marte Eilertsen, Michael Millar, Joseph Nariculam, Alex Freeman, Maria Notara, Mark R Feneley, Hitendra R H Patel, John R W Masters, Aamir Ahmed

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e84295 (2013)

Prostate carcinoma is the most common cancer in men with few, quantifiable, biomarkers. Prostate cancer biomarker discovery has been hampered due to subjective analysis of protein expression in tissue sections. An unbiased, quantitative immunohistoch

Externí odkaz: https://doaj.org/article/ce40de4751eb461690da7245bb3095b3

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

Autor: Mohammad Asim, Silvia Halim, Martin Mørck Mortensen, Hayley C. Whitaker, Adele Murrell, Anne Y. Warren, Simon A. Gayther, Alastair D. Lamb, Ian G. Mills, Jonathan D. Kay, Stephen J. Ball, Sebastian M. Armasu, Antonio Ramos-Montoya, Karina Dalsgaard Sørensen, Siri H. Strand, Claire M. Wells, Michael Borre, Kathryn Woodfine, Melissa C. Larson, Charles E. Massie, Kate Lawrenson, Ellen L. Goode, David E. Neal, Roslin Russell, Torben F. Ørntoft, Brooke L. Fridley, John R. W. Masters, Helen Ross-Adams

Publikováno v: Ross-Adams, H, Ball, S, Lawrenson, K, Halim, S, Russell, R, Wells, C, Strand, S H, Ørntoft, T F, Larson, M, Armasu, S, Massie, C E, Asim, M, Mortensen, M M, Borre, M, Woodfine, K, Warren, A Y, Lamb, A D, Kay, J, Whitaker, H, Ramos-Montoya, A, Murrell, A, Sørensen, K D, Fridley, B L, Goode, E L, Gayther, S A, Masters, J, Neal, D E & Mills, I G 2016, ' HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer ', Oncotarget, vol. 7, no. 46, pp. 74734-74746 . https://doi.org/10.18632/oncotarget.12543
Ross-Adams, H, Ball, S, Lawrenson, K, Halim, S, Russell, R, Wells, C, Strand, S H, Ørntoft, T F, Larson, M, Armasu, S, Massie, C E, Asim, M, Mortensen, M M, Borre, M, Woodfine, K, Warren, A Y, Lamb, A D, Kay, J, Whitaker, H, Ramos-Montoya, A, Murrell, A, Sørensen, K D, Fridley, B L, Goode, E L, Gayther, S A, Masters, J, Neal, D E & Mills, I G 2016, ' HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer ', Oncotarget . https://doi.org/10.18632/oncotarget.12543
Oncotarget
Ross-Adams, H, Ball, S J, Lawrenson, K, Halim, S, Russell, R, Wells, C, Strand, S, Ørntoft, T F, Larson, M C, Armasu, S M, Massie, C E, Asim, M, Mortensen, M M, Borre, M, Woodfine, K, Warren, A Y, Lamb, A D, Kay, J, Whitaker, H, Ramos-Montoya, A, Murrell, A, Sørensen, K D, Fridley, B L, Goode, E L, Gayther, S A, Masters, J R, Neal, D E & Mills, I G 2016, ' HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer ', OncoTarget, vol. 7, no. 46, pp. 74734-74746 . https://doi.org/10.18632/oncotarget.12543

Two independent regions within HNF1B are consistently identified in prostate and ovarian cancer genome-wide association studies (GWAS); their functional roles are unclear. We link prostate cancer (PC) risk SNPs rs11649743 and rs3760511 with elevated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1087fbe6b7f09cc62ecb72e3ad4e3d33
https://kclpure.kcl.ac.uk/en/publications/9de950f5-0783-47e3-8734-2c4c386c1c49

Biochemical relapse following radical prostatectomy and miR-200a levels in prostate cancer

Autor: Martin Clynes, Patrick Gammell, John R. W. Masters, Niall Barron, Joanne Keenan, Alex Freeman, Vanesa G. Martinez

Publikováno v: The Prostate. 72:1193-1199

BACKGROUND Radical prostatectomy cures the majority of men with clinically localized disease, but up to 30% of men relapse with rising serum PSA levels. Stage, Gleason grade, and pre-operative PSA levels are associated with outcome but do not accurat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a4c8d1dc97b6a6c9fe0e12b2353fba5
https://doi.org/10.1002/pros.22469

Check your cultures! A list of cross-contaminated or misidentified cell lines

Autor: George Theodosopoulos, John R. W. Masters, Yukio Nakamura, Roderick A.F. MacLeod, Roger R. Reddel, Hans G. Drexler, Isobel Atkin, Amanda Capes-Davis, Arihiro Kohara, Yvonne Reid, R. Ian Freshney

Publikováno v: International Journal of Cancer. 127:1-8

Continuous cell lines consist of cultured cells derived from a specific donor and tissue of origin that have acquired the ability to proliferate indefinitely. These cell lines are well-recognized models for the study of health and disease, particular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25282bac5dac586842e4a4576dcf83c2
https://doi.org/10.1002/ijc.25242