Zobrazeno 1 - 10
of 38
pro vyhledávání: '"R. W. Knowles"'
Autor:
Tatsuo Kawai, John A. Powelson, Robert B. Colvin, Francis L. Delmonico, R. W. Knowles, Cosimi Ab, S. L. Wee, G J Mourad, Frederic I. Preffer
Publikováno v:
Transplantation. 65:632-641
Background. Optimizing therapeutic monoclonal antibody (mAb) depends on the incorporation of the necessary effector functions and the development of hypoantigenic humanized antibodies by genetic engineering, which then need to be tested in appropriat
Autor:
Arthur J. Matas, Francis L. Delmonico, Thomas P. Haverty, Shelly Carter-Campbell, Lois McHugh, Mary Lin Farrell, Barbara A. Burke, Daniel R. Salomon, Robert Kale, Richard Thistlethwaite, Susan Quinn, R. W. Knowles, Anne S. Lindblad, Robert B. Colvin, Rita O'Laughlin, Benjamin H. Spargo, Donald Stablein, A. Benedict Cosimi
Publikováno v:
Transplantation. 63:1087-1095
Autor:
John A. Powelson, Robert B. Colvin, F K Preffer, Francis L. Delmonico, Cosimi Ab, R. W. Knowles, Tatsuo Kawai, Georges Mourad
Publikováno v:
Transplantation. 57:788-793
In an attempt to improve therapeutic efficacy and limit antimurine responses to the IgG2a monoclonal antibody OKT4A, humanized complementarity determining region (CDR)-grafted OKT4A mAbs (IgG1 and IgG4 isotypes) were developed from the murine molecul
Autor:
G J, Mourad, F I, Preffer, S L, Wee, J A, Powelson, T, Kawai, F L, Delmonico, R W, Knowles, A B, Cosimi, R B, Colvin
Publikováno v:
Transplantation. 65(5)
Optimizing therapeutic monoclonal antibody (mAb) depends on the incorporation of the necessary effector functions and the development of hypoantigenic "humanized" antibodies by genetic engineering, which then need to be tested in appropriate preclini
Autor:
Lucienne Chatenoud, Thomas P. Haverty, Louis Dubertret, Dominique Poisson, Sylvie Fraitag, Mary C. Wacholtz, R. W. Knowles, Béatrice Flageul, Jean-François Bach, Hervé Bachelez, R. Grossman, Nicole Brousse
Publikováno v:
Journal of autoimmunity. 11(1)
The presence of activated CD4(+) T lymphocytes in psoriatic skin plaques suggests an immune-mediated pathogenesis for the disease. Six patients with recalcitrant plaque psoriasis (PASI>12) received a humanized non-depleting monoclonal antibody to CD4
Nondepleting humanized anti-CD4 monoclonal antibody in patients with refractory rheumatoid arthritis
Publikováno v:
The Journal of rheumatology. 25(2)
To investigate the safety, tolerability, pharmacokinetics, and immunologic activity of single intravenous infusions (0.2-10 mg/kg) of Orthoclone OKTcdr4a, a nondepleting humanized anti-CD4 monoclonal antibody (Mab) in patients with rheumatoid arthrit
Autor:
J A, Powelson, R W, Knowles, F L, Delmonico, T, Kawai, G, Mourad, F K, Preffer, R B, Colvin, A B, Cosimi
Publikováno v:
Transplantation. 57(6)
In an attempt to improve therapeutic efficacy and limit antimurine responses to the IgG2a monoclonal antibody OKT4A, humanized complementarity determining region (CDR)-grafted OKT4A mAbs (IgG1 and IgG4 isotypes) were developed from the murine molecul
Autor:
D. E. Cavender, Jolliffe Lk, Cosimi Ab, Tatsuo Kawai, R. W. Knowles, Woan-Hwa Lee, Francis L. Delmonico
Publikováno v:
Transplantation. 55(4)
A nonhuman primate antimurine response (MAMA) has been observed in 17 cynomolgus renal allograft recipients of murine OKT 4A. Neither cyclosporine, nor total-lymphoid irradiation, nor donor bone marrow preparation inhibited this antixenogeneic respon
Autor:
F L, Delmonico, R W, Knowles, R B, Colvin, D E, Cavender, T, Kawai, M, Bedle, D, Stroka, F I, Preffer, C, Haug, A B, Cosimi
Publikováno v:
Transplantation proceedings. 25(1 Pt 1)
Autor:
D D, Eckels, A, Zeevi, P G, Beatty, N, Flomenberg, S, Goyert, R W, Knowles, E, Mickelson, G T, Nepom, P, Parham, G, Pawelec
Publikováno v:
Human Immunology. 15:68-74