Zobrazeno 1 - 10
of 74
pro vyhledávání: '"R. W. Estabrook"'
Publikováno v:
Biochemistry. Biokhimiia. 68(1)
To elucidate the nature of substrate specificity and intrinsic mechanism of hydroxylation of steroids, in the present work we carried out molecular cloning and heterologous expression of cDNA for three new forms of cytochrome P45017alpha from species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a281c64b2030f1d4440eab980ccdeecf
https://pubmed.ncbi.nlm.nih.gov/12693981
https://pubmed.ncbi.nlm.nih.gov/12693981
Publikováno v:
Journal of inorganic biochemistry. 87(4)
Cytochrome P450s (P450 or CYP) are the largest family of hemeproteins yet characterized. X-ray crystallographic studies have shown that the heme of the P450 hemeproteins is buried in the interior of the protein molecule. Unexplored are answers to que
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07f31b4c5759f819effadf607f666575
https://pubmed.ncbi.nlm.nih.gov/11744061
https://pubmed.ncbi.nlm.nih.gov/11744061
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(11)
The antiandrogenic drug, flutamide, is widely used in the treatment of carcinoma of the prostate. The present study examines the metabolism of flutamide by human liver microsomes and purified recombinant human cytochrome P450s (CYP), expressed as fus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c956b8f3093225b028f61cb11a926a90
https://pubmed.ncbi.nlm.nih.gov/9351907
https://pubmed.ncbi.nlm.nih.gov/9351907
Publikováno v:
Methods in enzymology. 272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53d9d68b5bf8bcf5f9c54b88440c46b5
https://pubmed.ncbi.nlm.nih.gov/8791761
https://pubmed.ncbi.nlm.nih.gov/8791761
Publikováno v:
Methods in enzymology. 272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fcc581b8a3105e065e6a47b2c012630
https://pubmed.ncbi.nlm.nih.gov/8791758
https://pubmed.ncbi.nlm.nih.gov/8791758
Autor:
A D, Rodrigues, D J, Mulford, R D, Lee, B W, Surber, M J, Kukulka, J L, Ferrero, S B, Thomas, M S, Shet, R W, Estabrook
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(7)
The metabolism of terfenadine was studied with a cDNA-expressed/purified recombinant fusion protein containing human liver microsomal cytochrome P4503A4 (CYP3A4) linked to rat NADPH-P450 reductase (rF450[mHum3A4/mRatOR]L1) and was compared with that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3b78a3cf5634588ff4cfca100165bfc3
https://pubmed.ncbi.nlm.nih.gov/7587966
https://pubmed.ncbi.nlm.nih.gov/7587966
Publikováno v:
The Journal of biological chemistry. 267(15)
Cytochrome P-450BM-3 is a catalytically self-sufficient fatty acid omega-hydroxylase with two domains. Functional and primary structure analyses of the hemo- and flavoprotein domains of cytochrome P-450BM-3 and the corresponding microsomal cytochrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5fe1824e1452215c63b6d0534d6dbc3a
https://pubmed.ncbi.nlm.nih.gov/1587824
https://pubmed.ncbi.nlm.nih.gov/1587824
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 6(2)
Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e89b398706e232439b18af6d8cd8baae
https://pubmed.ncbi.nlm.nih.gov/1537463
https://pubmed.ncbi.nlm.nih.gov/1537463
Publikováno v:
Current topics in cellular regulation. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1fa3c1f085e6fe23c2c70ee171c4d561
https://pubmed.ncbi.nlm.nih.gov/1499343
https://pubmed.ncbi.nlm.nih.gov/1499343
Publikováno v:
Methods in enzymology. 206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7f76c79ec316cc1c43cd58044277d86
https://pubmed.ncbi.nlm.nih.gov/1784230
https://pubmed.ncbi.nlm.nih.gov/1784230