Zobrazeno 1 - 10
of 76
pro vyhledávání: '"R. Van Ginckel"'
Autor:
Gerard Charles Sanz, B Janssen, J. Van Dun, L Dillen, C. Van Hove, Walter Wouters, J Van heusden, P Moelans, H Bruwiere, R Van Ginckel, G Willemsens, B.-J. Van Der Leede, Wim Floren, Michel Janicot, Marc Venet
Publikováno v:
British Journal of Cancer
All-trans-retinoic acid is a potent inhibitor of cell proliferation and inducer of differentiation. However, the clinical use of all-trans-retinoic acid in the treatment of cancer is significantly hampered by its toxicity and the prompt emergence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b534dd2944d23dbc3395a820b97d63
http://europepmc.org/articles/PMC2375285
http://europepmc.org/articles/PMC2375285
Publikováno v:
Cancer Chemotherapy and Pharmacology. 38:21-28
The aromatase inhibitor vorozole dose-dependently inhibited the growth of dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat. An oral dose of 5 mg/kg per day brought about growth inhibition and reduction of tumor multiplicity simil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749cfa752565b78acaa39869eae0b360
https://doi.org/10.1007/s002800050442
https://doi.org/10.1007/s002800050442
Autor:
Charlie Bowden, H. Vanden Bossche, A. Van Peer, P. A. J. Janssen, R. Van Ginckel, E. Snoeck, J. Bruynseels, R. De Coster, W. Wouters, R.W. Tuman
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 37:335-341
R76713 is a novel triazole derivative which selectively blocks the cytochrome P450-dependent aromatase. In human placental microsomes, in FSH-stimulated rat and human granulosa cells and in human adipose stromal cells, 50% inhibition of estradiol bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811edfb2ff27aaf7561e490a8eb6a34f
https://doi.org/10.1016/0960-0760(90)90482-z
https://doi.org/10.1016/0960-0760(90)90482-z
Autor:
Frans C. S. Ramaekers, R. Van Ginckel, G. Daneels, M. Borgers, M.-C. Coene, J.A. Schalken, M. Moeremans, G. Smets, J. Van Wauwe, R. De Coster
Publikováno v:
The Prostate. 27(3)
Liarozole showed antitumoral activity in the Dunning AT-6sq, an androgen-independent rat prostate carcinoma. To investigate its potential mechanism of action, the effects of the drug doses (ranging from 3.75 to 80 mg/kg b.i.d.) on endogenous plasma a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc8bc4bd2fdf9c9cae260ad3a25c2d7
https://pubmed.ncbi.nlm.nih.gov/7567691
https://pubmed.ncbi.nlm.nih.gov/7567691
Publikováno v:
Anticancer research. 13(6B)
Erbulozole (R55 104) is a water soluble congener of the microtubule inhibitor tubulozole, which has proven to possess anti-invasive, antitumoral and radiosensitizing capacities. A dose-finding study was performed on respectively 9 patients (every thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cce51fc0a53c95a2efb172034339f47b
https://pubmed.ncbi.nlm.nih.gov/8135472
https://pubmed.ncbi.nlm.nih.gov/8135472
Autor:
M. D. W. G. Krekels, R. Van Ginckel, M.-C. Coene, David W. End, R. De Coster, W. Wouters, Charlie Bowden
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 43(1-3)
Liarozole reduced tumor growth in the androgen-dependent Dunning-G and the androgen-independent Dunning MatLu rat prostate carcinoma models as well as in patients with metastatic prostate cancer who had relapsed after orchiectomy. In vitro , liarozol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce730d7a3e3f15dbd86cbf6183c4da2
https://pubmed.ncbi.nlm.nih.gov/1525060
https://pubmed.ncbi.nlm.nih.gov/1525060
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 38(4)
The aromatase enzyme and its inhibition by R 76 713 were characterized in the JEG-3 choriocarcinoma cell line in culture and in JEG-3 tumors grown in nude mice. Optimal cell culture parameters and enzyme reaction conditions for the determination of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735151a0eefa6cbc86055e94797c53da
https://pubmed.ncbi.nlm.nih.gov/2031856
https://pubmed.ncbi.nlm.nih.gov/2031856
Autor:
W, Distelmans, R, Van Ginckel, W, Vanherck, R, Willebrords, L, Wouters, M, De Brabander, J, Mesens
Publikováno v:
Anticancer research. 11(1)
The clinically applicable formulation of the microtubule inhibitor erbulozole (R 55 104), dissolved into an aqueous hydroxypropyl-beta-cyclodextrin solution (designated as R 55 104-CYCLO), exerts a similar effect on growth delay of subcutaneous MO4 f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8a43443264f95ebfddb41dedc7440ce
https://pubmed.ncbi.nlm.nih.gov/2018359
https://pubmed.ncbi.nlm.nih.gov/2018359
Autor:
Els Jagers, P. A. J. Janssen, R. De Coster, N. Goeminne, W. Wouters, Luc Wouters, W. Distelmans, R. Van Ginckel, W. Vanherck, R. Der Van Veer, H. Van Cauteren
Publikováno v:
The Prostate. 16(4)
The antitumoral activity of a novel imidazole derivative, R 75,251, has been studied in the androgen-dependent R3327G Dunning prostate adenocarcinoma grafted subcutaneously in syngeneic rats. Dietary application resulting approximately in dose levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17b2f83f7146b1f570e7f6a44549800
https://pubmed.ncbi.nlm.nih.gov/2371176
https://pubmed.ncbi.nlm.nih.gov/2371176
Publikováno v:
European Journal of Cancer. 29:S76
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::255e99b7d50fbacc79c21fa4af7f5c10
https://doi.org/10.1016/0959-8049(93)91019-h
https://doi.org/10.1016/0959-8049(93)91019-h