Dysregulation of epithelial ion transport and neurochemical changes in the colon of a parkinsonian primate

Autor: Erika Coletto, Iain R. Tough, Sara Pritchard, Atsuko Hikima, Michael J. Jackson, Peter Jenner, K. Ray Chaudhuri, Helen M. Cox, Mahmoud M. Iravani, Sarah Rose

Publikováno v: npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-11 (2021)

Abstract The pathological changes underlying gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) are poorly understood and the symptoms remain inadequately treated. In this study we compared the functional and neurochemical changes in the

Externí odkaz: https://doaj.org/article/510bc52c596442c9b171cfd7f59f12c7

Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney

Autor: Elina Akalestou, Livia Lopez-Noriega, Iain R. Tough, Ming Hu, Isabelle Leclerc, Helen M. Cox, Guy A. Rutter

Publikováno v: Diabetes. 71:1623-1635

Bariatric surgery improves glucose homeostasis but the underlying mechanisms are not fully elucidated. Here, we show that the expression of sodium glucose cotransporter-2 (SGLT2/Slc5a2) is reduced in the kidney of lean and obese mice following vertic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014afd61f26a8b24f371277db6399253
https://doi.org/10.2337/db21-0768

Highly Selective Y4 Receptor Antagonist Binds in an Allosteric Binding Pocket

Autor: Corinna Schüß, Kyle A. Emmitte, Jan Stichel, Oanh Vu, Jens Meiler, C. David Weaver, Helen M. Cox, Nigam M. Mishra, Iain R. Tough, Annette G. Beck-Sickinger, Mario Schubert, Yu Du

Publikováno v: Journal of Medicinal Chemistry. 64:2801-2814

Human neuropeptide Y receptors (Y1R, Y2R, Y4R, and Y5R) belong to the superfamily of G protein-coupled receptors and play an important role in the regulation of food intake and energy metabolism. We identified and characterized the first selective Y4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83326529104d38a3671fa39f6bfc0219
https://doi.org/10.1021/acs.jmedchem.0c02000

Dysregulation of epithelial ion transport and neurochemical changes in the colon of a parkinsonian primate

Autor: Michael J. Jackson, Atsuko Hikima, Erika Coletto, Helen M. Cox, Mahmoud M. Iravani, Sara Pritchard, Peter Jenner, Sarah Rose, Iain R. Tough, K. Ray Chaudhuri

Publikováno v: NPJ Parkinson's Disease
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-11 (2021)

The pathological changes underlying gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) are poorly understood and the symptoms remain inadequately treated. In this study we compared the functional and neurochemical changes in the enteric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006d558e3ec86cf7d29a39d1bfc46832
http://europepmc.org/articles/PMC7820491

Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist

Autor: Birgitte Holst, Chunyu Jin, Siv A. Hjorth, Anders Bach, Michel Bouvier, Jesse A. Buijink, Natalia Petersen, Louis M.E. Sørensen, Helen M. Cox, Michael Patrick Achiam, Louise J. Skov, Lingzhi Liu, Iain R. Tough, Thi Ai Diep, Kaare V. Grunddal, Franziska Mende, Thomas M. Frimurer, Bolette Hartmann, Sara L. Jepsen, Rune B Strandby

Publikováno v: Grunddal, K V, Diep, T A, Petersen, N, Tough, I R, Skov, L J, Liu, L, Buijink, J A, Mende, F, Jin, C, Jepsen, S L, Sørensen, L M E, Achiam, M P, Strandby, R B, Bach, A, Hartmann, B, Frimurer, T M, Hjorth, S A, Bouvier, M, Cox, H & Holst, B 2021, ' Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist ', Molecular Metabolism, vol. 49, 101207 . https://doi.org/10.1016/j.molmet.2021.101207
Molecular Metabolism, Vol 49, Iss, Pp 101207-(2021)
Molecular Metabolism

Objectives Obesity is a complex disease associated with a high risk of comorbidities. Gastric bypass surgery, an invasive procedure with low patient eligibility, is currently the most effective intervention that achieves sustained weight loss. This b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03506f25693ca35449bd491b3d4bd86e
https://doi.org/10.1016/j.molmet.2021.101207