Genome-Wide Association Study Using Extreme Truncate Selection Identifies Novel Genes Affecting Bone Mineral Density and Fracture Risk

Autor: Kari Stefansson, Rajesh V. Thakker, Mark A. Kotowicz, J. B. Richards, Richard L. Prince, John D. Wark, K. Pryce, Cyrus Cooper, Johanna Hadler, S.C. Nguyen, Karol Estrada, K. Addison, Elaine M. Dennison, Margaret J. Henry, John P. Kemp, David M. Reid, Julie A. Pasco, Christopher T. Esapa, David M. Evans, Eugene V. McCloskey, Graeme Jones, P. N. Sambrook, Matthew A. Brown, Albert Hofman, Tuan V. Nguyen, Unnur Styrkarsdottir, Patrick Danoy, Linda A. Bradbury, Joanna Makovey, Gudmar Thorleifsson, R. Tichawangana, Claus-Christian Glüer, Dieter Felsenberg, Tim D. Spector, Fernando Rivadeneira, André G. Uitterlinden, Emma L. Duncan, Paul Leo, John A. Eisman, R. Eastell, Steve D.M. Brown, C. Roux, Roger D. Cox, G.C. Nicholson, Ian R. Reid, C. Cremin

Publikováno v: PLoS Genetics (print), 7(4). Public Library of Science
PLoS Genetics, Vol 7, Iss 4, p e1001372 (2011)
PLoS Genetics; Vol 7
PLoS Genetics
Plos Genetics, 7(4):e1001372. Public Library of Science

Osteoporotic fracture is a major cause of morbidity and mortality worldwide. Low bone mineral density (BMD) is a major predisposing factor to fracture and is known to be highly heritable. Site-, gender-, and age-specific genetic effects on BMD are th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce90a5e7796fae0780ce78fb4c49870
https://doi.org/10.1371/journal.pgen.1001372

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