Development and Application of a Scintillation Proximity Assay (SPA) for Identification of Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1

Autor: Steven S. Mundt, Kelli Solly, R. Thieringer, Anne Hermanowski-Vosatka

Publikováno v: ASSAY and Drug Development Technologies. 3:367-375

Pre-receptor metabolism of glucocorticoids by the 11beta-hydroxysteroid dehydrogenase (11betaHSD) enzymes has been implicated in the etiology of the metabolic syndrome. Recent studies have shown that alterations in the activity of the type 1 isozyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d1e7314b7c77ac5eb11bd1ed06cd24
https://doi.org/10.1089/adt.2005.3.367

Beta-oxidation system of the filamentous fungus Neurospora crassa. Structural characterization of the trifunctional protein

Autor: R. Thieringer, W H Kunau

Publikováno v: Journal of Biological Chemistry. 266:13118-13123

Treatment of the trifunctional protein from Neurospora crassa with various proteases produced almost identical patterns of proteolytic fragments. To study the structural features of the protein in more detail limited proteolysis with trypsin was carr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ece04cf6e6cfdaaad2b97b59ae52bdfe
https://doi.org/10.1016/s0021-9258(18)98812-5

Role of stress-activated mitogen-activated protein kinase (p38) in beta 2-integrin-dependent neutrophil adhesion and the adhesion-dependent oxidative burst

Autor: P A, Detmers, D, Zhou, E, Polizzi, R, Thieringer, W A, Hanlon, S, Vaidya, V, Bansal

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(4)

Bacterial LPS elicits both rapid activation of the stress-activated MAP kinase p38 in polymorphonuclear leukocytes (PMN) and rapid adhesion of the PMN to ligands for the leukocyte integrin CD11b/CD18. The functional correlation between these two even

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91317bb468c1000e7d9dbca239bddd0e
https://pubmed.ncbi.nlm.nih.gov/9712062

Contents Vol. 105, 2004

Autor: A. Orth, F.H. Chen, G. Remuzzi, F. Oesch, K.E. Latham, V. Merico, M. Boiani, D. Taruscio, S.K. Smith, B. Dutrillaux, P.M. Wassarman, E.S. Litscher, J. Lamb, M. Morigi, M. Monti, C. Dong, A.M. Morescalchi, K. Belkhir, D. Prawitt, H.R. Schöler, P.B. Moens, E.E. Radford, L. Eshkind, N. Grandi, R. Marchal, H.H.Q. Heng, D. Churikov, R.J. Smith, D. Solter, L. Brixel, R. Knoth, R. Heck, D. GuhaThakurta, P. Arnaud, D. Kipling, P. Svoboda, S.H. Kim, B. Volk, N.K. Kolas, M. Calvani, A.O. Zalensky, I. Gündüz, M. Hemberger, A.B. Sachs, Dagmar Wilhelm, E. Whitelaw, W.N. de Vries, T. Cremer, M.A. Handel, I. Solovei, D.J. Wolgemuth, J.K. Pendola, J.C. Schimenti, M.K. Lichtman, P.Y. Lum, C. Spangenberg, T. Misteli, W. Traut, A. Mantovani, A. Chicheportiche, J.P. Berger, B. Zabel, K.S. Fancher, J.B. Searle, A.V. Evsikov, E. Capanna, R. Nicolai, J. Gerdes, E.E. Schadt, V. Sebastiano, A.E. Peaston, S. Gao, C.A. Redi, H. Tamada, K. Shiota, C. Tease, C.J. Bult, S.W. Edwards, U. Zechner, F. Yang, C. Moulia, F. Sangiuolo, R. Thieringer, R. Stanyon, S. Schlatt, E.M. Shevach, G. Kelsey, J. Thompson, S. Garagna, L. Galleni, M.A. Hultén, J. Piálek, T. Panithanarak, S. Chong, L. Gentile, H.C. Hauffe, A. Benigni, C. Spadafora, J.J. Duquesne, V. Gambles, C. Hoog, L. Yuan, M. Tankimanova, N. Galtier, L. Jovine, I.A. Zalenskaya, Peter Koopman, E. Desmarais, G. Novelli, P.G. McQueen, P. Boursot, J.J. Eppig, J.F. Dallas, S.S.W. Chung, J. Wistuba, E. Marcon, M. Zuccotti, S.A. Hartford, Jiu Yang Zhu, P. Caminade, R. Castiglia, R.F. Kooy, L.A. Parada, Z. Xin, H.-P. Wong, M.S. Wu, H. Winking, N. Kikyo, V. Errijgers, B. Dod, J. Bernardino-Sgherri, C. Zoja, E. Bockamp, P. Slijepcevic, B.B. Knowles, V von Schönfeldt, C. Lessard, T. Ashley, D. Broccoli, F. Bonhomme, J.A. Blake

Publikováno v: Cytogenetic and Genome Research. 105:487-488

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cf69c5eec5a660bd388bb9cee7b99e4
https://doi.org/10.1159/000079516

Peroxisome-deficient Chinese hamster ovary cells with point mutations in peroxisome assembly factor-1

Autor: R, Thieringer, C R, Raetz

Publikováno v: The Journal of biological chemistry. 268(17)

Chinese hamster ovary (CHO) mutant cells deficient in peroxisome biogenesis regain peroxisomes after transfection with a cDNA coding for peroxisome assembly factor (PAF)-1 from rat liver. Reconstitution of the transfected mutant cells with wild-type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::397cb3bd9e3188d60ab04d8c0d7c592a
https://pubmed.ncbi.nlm.nih.gov/7685346