Zobrazeno 1 - 10
of 260
pro vyhledávání: '"R. Tee"'
Autor:
Muireann Ní Bhaoighill, Juan M. Falcón‐Pérez, Félix Royo, Andrew R. Tee, Jason P. Webber, Elaine A. Dunlop
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 6, Pp n/a-n/a (2023)
Abstract Hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) is a feature of many solid tumours and is a key pathogenic driver in the inherited condition Tuberous Sclerosis Complex (TSC). Modulation of the tumour microenvironment by
Externí odkaz:
https://doaj.org/article/8c6f1cb68aad4a4b801ac9725eaa29a1
Autor:
Jesse D. Champion, Kayleigh M. Dodd, Hilaire C. Lam, Mohammad A. M. Alzahrani, Sara Seifan, Ellie Rad, David Oliver Scourfield, Melissa L. Fishel, Brian L. Calver, Ann Ager, Elizabeth P. Henske, David Mark Davies, Mark R. Kelley, Andrew R. Tee
Publikováno v:
Cancers, Vol 14, Iss 24, p 6195 (2022)
Therapies with the mechanistic target of rapamycin complex 1 (mTORC1) inhibitors are not fully curative for tuberous sclerosis complex (TSC) patients. Here, we propose that some mTORC1-independent disease facets of TSC involve signaling through redox
Externí odkaz:
https://doaj.org/article/3bf658cf11574049a9c3079b20859943
Autor:
Bernadette Carroll, Dorothea Maetzel, Oliver DK Maddocks, Gisela Otten, Matthew Ratcliff, Graham R Smith, Elaine A Dunlop, João F Passos, Owen Richard Davies, Rudolf Jaenisch, Andrew R Tee, Sovan Sarkar, Viktor I Korolchuk
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/6b2cf351d8cb4f19aed05575781ae9dc
Akademický článek
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Publikováno v:
The Journal of chemical physics. 157(8)
Constant potential methods (CPMs) enable computationally efficient simulations of the solid-liquid interface at conducting electrodes in molecular dynamics. They have been successfully used, for example, to realistically model the behavior of ionic l
Autor:
Yan Tong, Silpa Gampala, Ellie Rad, Ren Yuan Bai, Olivia Babb, Emily Hulsey, Fenil Shah, Chi Zhang, Steven D. Rhodes, Verena Staedtke, Randall Wireman, Brian L. Calver, Mark R. Kelley, Michelle Grimard, M. Reza Saadatzadeh, Abbi Smith, D. Wade Clapp, Andrew R. Tee, Karen E. Pollok, Melissa L. Fishel
Publikováno v:
British Journal of Cancer
Background MPNST is a rare soft-tissue sarcoma that can arise from patients with NF1. Existing chemotherapeutic and targeted agents have been unsuccessful in MPNST treatment, and recent findings implicate STAT3 and HIF1-α in driving MPNST. The DNA-b
Autor:
Pranetha Baskaran, Simeon R. Mihaylov, Elin Vinsland, Kriti Shah, Lucy Granat, Sila K. Ultanir, Andrew R. Tee, Jernej Murn, Joseph M. Bateman
Mechanistic target of rapamycin (mTOR) is a protein kinase that integrates multiple inputs to regulate anabolic cellular processes. For example , mTOR complex I (mTORC1) has key functions in growth control, autophagy and metabolism. However, much les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a295d25117790d96fd0b7bde71d2fc
https://doi.org/10.1101/2022.04.08.487575
https://doi.org/10.1101/2022.04.08.487575
Autor:
Henry D. McCann, Charlotte E. Johnson, Rachel J. Errington, D. Mark Davies, Elaine A. Dunlop, Andrew R. Tee
Publikováno v:
Cancers, Vol 10, Iss 10, p 375 (2018)
To find new anti-cancer drug therapies, we wanted to exploit homeostatic vulnerabilities within Tuberous Sclerosis Complex 2 (TSC2)-deficient cells with mechanistic target of rapamycin complex 1 (mTORC1) hyperactivity. We show that nelfinavir and mef
Externí odkaz:
https://doaj.org/article/05b44a71a37043bcb028a1fc33b65b81