Zobrazeno 1 - 10
of 343
pro vyhledávání: '"R. Talon"'
Autor:
E. LE BIHAN-DUVAL, R. TALON, M. BROCHARD, J. GAUTRON, F. LEFÈVRE, C. LARZUL, E. BAÉZA, J.F. HOCQUETTE
Publikováno v:
INRAE Productions Animales, Vol 27, Iss 3 (2014)
Maîtriser la qualité des produits issus des animaux d’élevage suppose de pouvoir l’objectiver à partir de mesures fiables, faciles d’utilisation et si possible précoces et non invasives. Les programmes de recherche-développement mis en pl
Externí odkaz:
https://doaj.org/article/f8746d10db2144c6b19e1e1a4df9bc8f
Autor:
Sonia M Vallabh, José Brandão-Neto, Maria Cristina Nonato, R. Talon, Leandro Oliveira Bortot, Armin Wagner, Stuart L. Schreiber, Frank von Delft, Eric Vallabh Minikel, Kamel El Omari, Andrew G. Reidenbach, Francesca A. Pavlovici, V.L. Rangel
Publikováno v:
Biochimie
Prion disease is caused by the misfolding of the cellular prion protein, PrPC, into a self-templating conformer, PrPSc. Nuclear magnetic resonance (NMR) and X-ray crystallography revealed the 3D structure of the globular domain of PrPC and the possib
Autor:
Olivier Maury, Sebastiano Di Pietro, François Riobé, Sylvain Engilberge, Guillaume Pilet, R. Talon, Adeline Robin, Seigo Shima, Zaynab Alsalman, Elise Dumont, Anthony D'Aléo, Tristan Wagner, Alessio Bartocci, Eric Girard, Amandine Roux
Publikováno v:
Inorganic Chemistry
Inorganic Chemistry, 2021, 60 (20), pp.15208-15214. ⟨10.1021/acs.inorgchem.1c01635⟩
Inorganic Chemistry, American Chemical Society, 2021, 60 (20), pp.15208-15214. ⟨10.1021/acs.inorgchem.1c01635⟩
Inorganic Chemistry, 2021, 60 (20), pp.15208-15214. ⟨10.1021/acs.inorgchem.1c01635⟩
Inorganic Chemistry, American Chemical Society, 2021, 60 (20), pp.15208-15214. ⟨10.1021/acs.inorgchem.1c01635⟩
International audience; Lanthanide complexes are now widely used as powerful auxiliaries for protein crystallisation to improve the crucial nucleation and phasing steps. We systematically analysed the influence of the commercial crystallisation kit c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e50d640c125462eedd4007fb3492dd
https://hdl.handle.net/21.11116/0000-0009-8575-D21.11116/0000-0009-8577-B
https://hdl.handle.net/21.11116/0000-0009-8575-D21.11116/0000-0009-8577-B
Autor:
Anthony R. Bradley, Michael Fairhead, Storm Hassell-Hart, Iain J. Day, John Spencer, R. Talon, Kamlesh Bala, S. Velupillai, T. Krojer, Raysa Khan Tareque, Frank von Delft, Robert Felix, Paul Brennan, Kilian Huber, Laura Diaz Saez, Paul D. Kemmitt
Combined photochemical arylation, "nuisance effect" (SN Ar) reaction sequences have been employed in the design of small arrays for immediate deployment in medium-throughput X-ray protein-ligand structure determination. Reactions were deliberately al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e4bb4585201f3df3be8f4a04dc71d2
https://ora.ox.ac.uk/objects/uuid:80a110f0-a48b-4503-8575-28f607938f06
https://ora.ox.ac.uk/objects/uuid:80a110f0-a48b-4503-8575-28f607938f06
Autor:
R. Talon, Joseph McLoughlin, Michael Fairhead, Anthony R. Bradley, Dom Bellini, Thomas Armetirding Compton, Katherine McAuley, Paul Brear, Sarah L. Kidd, L. Diaz-Saez, Frank von Delft, T. Krojer, Elaine Fowler, Natalia Mateu, Marko Hyvönen, Christopher G. Dowson, Kilian Huber, A. Aimon, Andrew Madin, Daniel Hillebrand O'donovan, Hector Newman, Hannah F. Sore, Till Reinhardt, David R. Spring
Publikováno v:
Chemical Science
Organic synthesis underpins the evolution of weak fragment hits into potent lead compounds. Deficiencies within current screening collections often result in the requirement of significant synthetic investment to enable multidirectional fragment grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181cdfacf1976d86f9fc05ba09cd03cf
http://wrap.warwick.ac.uk/136960/1/WRAP-demonstration-utility-DOS-derived-fragment-libraries-rapid-hit-derivatisation-multidirectional-fashion-Dowson-2020.pdf
http://wrap.warwick.ac.uk/136960/1/WRAP-demonstration-utility-DOS-derived-fragment-libraries-rapid-hit-derivatisation-multidirectional-fashion-Dowson-2020.pdf
Autor:
M Ye, F. von Delft, N D Wright, E.R. Nelson, H.J. Wiggers, N Mitrovich, P.M. Collins, J.A. Newman, R. Talon, Radosław P. Nowak, J. Ng, L. Koekemoer
Despite the tremendous success of x-ray cryocrystallography over recent decades, the transfer of crystals from the drops where they grow to diffractometer sample mounts, remains a manual process in almost all laboratories. Here we describe the Shifte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e0ffbb491ba6555e8ac2c1000dc273
https://doi.org/10.1101/2019.12.20.875674
https://doi.org/10.1101/2019.12.20.875674
Autor:
R. Talon, J.A. Newman, T. Krojer, Nick Mitrovich, Frank von Delft, Radosław P. Nowak, Helton Wiggers, P.M. Collins, Lizbé Koekemoer, Nathan David Wright, J. Ng, Mingda Ye, Elliot Nelson
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
A motorized X–Y microscope stage is presented that combines human fine motor control with machine assistance and automated experiment documentation in order to transform productivity in protein crystal harvesting.
Despite the tremendous succes
Despite the tremendous succes
Akademický článek
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Autor:
Frank von Delft, Alice Douangamath, Alexandre Dias, R. Talon, T. Krojer, José Brandão-Neto, P.M. Collins
Publikováno v:
Modern Approaches in Drug Discovery. 610
The XChem facility at Diamond Light Source offers fragment screening by X-ray crystallography as a general access user program. The main advantage of X-ray crystallography as a primary fragment screen is that it yields directly the location and pose
Autor:
R. Talon, Nathan T. Wright, Frank von Delft, José Brandão-Neto, Karolina Nekrosiute, P.M. Collins, J. Ng, Nicholas M Pearce, T. Krojer, Alice Douangamath
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
A high-throughput method is described for crystal soaking using acoustic droplet ejection, and its effectiveness is demonstrated.
The steady expansion in the capacity of modern beamlines for high-throughput data collection, enabled by increasing
The steady expansion in the capacity of modern beamlines for high-throughput data collection, enabled by increasing