TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells

Autor: D. Wünkhaus, R. Tang, K. Nyame, N. N. Laqtom, M. Schweizer, A. Scotto Rosato, E. K. Krogsæter, C. Wollnik, M. Abu-Remaileh, C. Grimm, G. Hermey, R. Kuhn, D. Gruber-Schoffnegger, S. Markmann

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)

Abstract Mutations in the lysosomal membrane protein CLN3 cause Juvenile Neuronal Ceroid Lipofuscinosis (JNCL). Activation of the lysosomal ion channel TRPML1 has previously been shown to be beneficial in several neurodegenerative disease models. Her

Externí odkaz: https://doaj.org/article/ac794277aab54adeb8875f2051f6f6e4

A coarse pixel-scale ground 'truth' dataset based on global in situ site measurements to support validation and bias correction of satellite surface albedo products

Autor: F. Pan, X. Wu, Q. Zeng, R. Tang, J. Wang, X. Lin, D. You, J. Wen, Q. Xiao

Publikováno v: Earth System Science Data, Vol 16, Pp 161-176 (2024)

In situ measurements from sparsely distributed networks worldwide are a critical source of reference data for validating or correcting biases in satellite products. However, due to the substantial difference in spatial scales between in situ and sate

Externí odkaz: https://doaj.org/article/111a9a68703141b2ac8b670683e9208e

Detection of Very High-energy Gamma-Ray Emission from the Radio Galaxy M87 with LHAASO

Autor: Zhen Cao, F. Aharonian, Axikegu, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, W. Bian, A. V. Bukevich, Q. Cao, W. Y. Cao, Zhe Cao, J. Chang, J. F. Chang, A. M. Chen, E. S. Chen, H. X. Chen, Liang Chen, Lin Chen, Long Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, M. C. Chu, M. Y. Cui, S. W. Cui, X. H. Cui, Y. D. Cui, B. Z. Dai, H. L. Dai, Z. G. Dai, Danzengluobu, X. Q. Dong, K. K. Duan, J. H. Fan, Y. Z. Fan, J. Fang, J. H. Fang, K. Fang, C. F. Feng, H. Feng, L. Feng, S. H. Feng, X. T. Feng, Y. Feng, Y. L. Feng, S. Gabici, B. Gao, C. D. Gao, Q. Gao, W. Gao, W. K. Gao, M. M. Ge, T. T. Ge, L. S. Geng, G. Giacinti, G. H. Gong, Q. B. Gou, M. H. Gu, F. L. Guo, J. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, O. A. Hannuksela, M. Hasan, H. H. He, H. N. He, J. Y. He, Y. He, Y. K. Hor, B. W. Hou, C. Hou, X. Hou, H. B. Hu, Q. Hu, S. C. Hu, C. Huang, D. H. Huang, T. Q. Huang, W. J. Huang, X. T. Huang, X. Y. Huang, Y. Huang, Y. Y. Huang, X. L. Ji, H. Y. Jia, K. Jia, H. B. Jiang, K. Jiang, X. W. Jiang, Z. J. Jiang, M. Jin, M. M. Kang, I. Karpikov, D. Khangulyan, D. Kuleshov, K. Kurinov, B. B. Li, C. M. Li, Cheng Li, Cong Li, D. Li, F. Li, H. B. Li, H. C. Li, Jian Li, Jie Li, K. Li, S. D. Li, W. L. Li, X. R. Li, Xin Li, Y. Z. Li, Zhe Li, Zhuo Li, E. W. Liang, Y. F. Liang, S. J. Lin, B. Liu, C. Liu, D. Liu, D. B. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, M. Y. Liu, R. Y. Liu, S. M. Liu, W. Liu, Y. Liu, Y. N. Liu, Q. Luo, Y. Luo, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, Z. Min, W. Mitthumsiri, H. J. Mu, Y. C. Nan, A. Neronov, K. C. Y. Ng, L. J. Ou, P. Pattarakijwanich, Z. Y. Pei, J. C. Qi, M. Y. Qi, B. Q. Qiao, J. J. Qin, A. Raza, D. Ruffolo, A. Sáiz, M. Saeed, D. Semikoz, L. Shao, O. Shchegolev, X. D. Sheng, F. W. Shu, H. C. Song, Yu. V. Stenkin, V. Stepanov, Y. Su, D. X. Sun, Q. N. Sun, X. N. Sun, Z. B. Sun, J. Takata, P. H. T. Tam, Q. W. Tang, R. Tang, Z. B. Tang, W. W. Tian, L. H. Wan, C. Wang, C. B. Wang, G. W. Wang, H. G. Wang, H. H. Wang, J. C. Wang, Kai Wang, L. P. Wang, L. Y. Wang, P. H. Wang, R. Wang, W. Wang, X. G. Wang, X. Y. Wang, Y. Wang, Y. D. Wang, Y. J. Wang, Z. H. Wang, Z. X. Wang, Zhen Wang, Zheng Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, Q. W. Wu, S. Wu, X. F. Wu, Y. S. Wu, S. Q. Xi, J. Xia, G. M. Xiang, D. X. Xiao, G. Xiao, Y. L. Xin, Y. Xing, D. R. Xiong, Z. Xiong, D. L. Xu, R. F. Xu, R. X. Xu, W. L. Xu, L. Xue, D. H. Yan, J. Z. Yan, T. Yan, C. W. Yang, C. Y. Yang, F. Yang, F. F. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, W. X. Yang, Y. H. Yao, Z. G. Yao, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. Yue, H. D. Zeng, T. X. Zeng, W. Zeng, M. Zha, B. B. Zhang, F. Zhang, H. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, Li Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. B. Zhang, S. R. Zhang, S. S. Zhang, X. Zhang, X. P. Zhang, Y. F. Zhang, Yi Zhang, Yong Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, X. H. Zhao, F. Zheng, W. J. Zhong, B. Zhou, H. Zhou, J. N. Zhou, M. Zhou, P. Zhou, R. Zhou, X. X. Zhou, B. Y. Zhu, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu, Y. C. Zou, X. Zuo

Publikováno v: The Astrophysical Journal Letters, Vol 975, Iss 2, p L44 (2024)

The nearby radio galaxy M87 is a very high-energy (VHE) gamma-ray emitter established by observations with ground-based gamma-ray detectors. Here we report the long-term monitoring of M87 from 2021 to 2024 with the Large High Altitude Air Shower Obse

Externí odkaz: https://doaj.org/article/711146067b854fd282cfbf84f5b78991

Sulfate formation via aerosol-phase SO2 oxidation by model biomass burning photosensitizers: 3,4-dimethoxybenzaldehyde, vanillin and syringaldehyde using single-particle mixing-state analysis

Autor: L. Zhou, Z. Liang, B. R. G. Mabato, R. A. I. Cuevas, R. Tang, M. Li, C. Cheng, C. K. Chan

Publikováno v: Atmospheric Chemistry and Physics, Vol 23, Pp 5251-5261 (2023)

Atmospheric oxidation of sulfur dioxide (SO2) to sulfate has been widely investigated by means of gas-phase and in-cloud chemistry studies. Recent field measurements have shown significant sulfate formation in cloud-free environments with high aeroso

Externí odkaz: https://doaj.org/article/e6e1eb6d05ac4620b6f955a603490e49

Mass spectral characterization of secondary organic aerosol from urban cooking and vehicular sources

Autor: W. Zhu, S. Guo, Z. Zhang, H. Wang, Y. Yu, Z. Chen, R. Shen, R. Tan, K. Song, K. Liu, R. Tang, Y. Liu, S. Lou, Y. Li, W. Zhang, S. Shuai, H. Xu, S. Li, Y. Chen, M. Hu, F. Canonaco, A. S. H. Prévôt

Publikováno v: Atmospheric Chemistry and Physics, Vol 21, Pp 15065-15079 (2021)

In the present work, we conducted experiments of secondary organic aerosol (SOA) formation from urban cooking and vehicular sources to characterize the mass spectral features of primary organic aerosol (POA) and SOA using an high-resolution time-of-f

Externí odkaz: https://doaj.org/article/a0de06d828654b6f82a0b2277ae5f28a