Zobrazeno 1 - 10
of 416
pro vyhledávání: '"R. T. Van"'
Autor:
G. A. Kalkman, C. Kramers, R. T. van Dongen, H. J. Schers, R. L. M. van Boekel, J. M. Bos, K. Hek, A. F. A. Schellekens, F. Atsma
Publikováno v:
PLoS ONE, Vol 18, Iss 2 (2023)
Background Prescription opioid use has increased steadily in many Western countries over the past two decades, most notably in the US, Canada, and most European countries, including the Netherlands. Especially the increasing use of prescription opioi
Externí odkaz:
https://doaj.org/article/a6008f09b027431087d63e3a67dc3258
Publikováno v:
Earth Surface Dynamics, Vol 8, Pp 527-553 (2020)
The way in which sediment is transported (creep, saltation, suspension), is traditionally interpreted from grain size distribution characteristics. However, the grain size range associated with transitions from one transport mode to the other is high
Externí odkaz:
https://doaj.org/article/c98de4d2fcc249c9bff8f28e05a32d96
Autor:
W. J. Koemans, R. T. van der Kaaij, H. Boot, T. Buffart, A. A. F. A. Veenhof, K. J. Hartemink, C. Grootscholten, P. Snaebjornsson, V. P. Retel, H. van Tinteren, S. Vanhoutvin, V. van der Noort, A. Houwink, C. Hahn, A. D. R. Huitema, M. Lahaye, M. Los, P. van den Barselaar, O. Imhof, A. Aalbers, G. M. van Dam, B. van Etten, B. P. L. Wijnhoven, M. D. P. Luyer, D. Boerma, J. W. van Sandick
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background At present, palliative systemic chemotherapy is the standard treatment in the Netherlands for gastric cancer patients with peritoneal dissemination. In contrast to lymphatic and haematogenous dissemination, peritoneal disseminatio
Externí odkaz:
https://doaj.org/article/917d7bd8f3964810bccea2a516335683
Publikováno v:
Hydrology and Earth System Sciences, Vol 12, Iss 1, Pp 159-175 (2008)
In recent years the frequency of high-flow events on the Meuse (northwest Europe) has been relatively great, and flooding has become a major research theme. To date, research has focused on observed discharge records of the last century and simulatio
Externí odkaz:
https://doaj.org/article/86adb75ec8f7473caa91da8b04aaa723
Autor:
Marieke Meijer, Miriam Öttl, Jie Yang, Aygul Subkhangulova, Avinash Kumar, Zicheng Feng, Torben W. van Voorst, Alexander J. Groffen, Jan R. T. van Weering, Yongli Zhang, Matthijs Verhage
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Tomosyns are widely thought to attenuate membrane fusion by competing with synaptobrevin-2/VAMP2 for SNARE-complex assembly. Here, we present evidence against this scenario. In a novel mouse model, tomosyn-1/2 deficiency lowered the fusion b
Externí odkaz:
https://doaj.org/article/9e5ac04838014cfc9c47148fbd0d6295
Autor:
Pascal R. D. Clephas, Jishnu Malgie, Jeroen Schaap, Stefan Koudstaal, Mireille Emans, Gerard C. M. Linssen, Grytsje A. deBoer, Loek vanHeerebeek, C. Jan Willem Borleffs, Olivier C. Manintveld, Vanessa vanEmpel, Sandra vanWijk, Mieke van denHeuvel, Carlos daFonseca, Kevin Damman, Jan vanRamshorst, Roland vanKimmenade, Arjen R. T. van deVen, René A. Tio, Dennis vanVeghel, Folkert W. Asselbergs, Rudolf A. deBoer, Peter van derMeer, Stephen J. Greene, Hans‐Peter Brunner‐La Rocca, Jasper J. Brugts
Publikováno v:
ESC Heart Failure, Vol 11, Iss 1, Pp 550-559 (2024)
Abstract Aims Current heart failure (HF) guidelines recommend to prescribe four drug classes in patients with HF with reduced ejection fraction (HFrEF). A clear challenge exists to adequately implement guideline‐directed medical therapy (GDMT) rega
Externí odkaz:
https://doaj.org/article/76fc22140ff146f4acc31d2d5d84e800
Autor:
Mandy S. J. Kater, Katharina F. Baumgart, Aina Badia‐Soteras, Tim S. Heistek, Karen E. Carney, A. Jacob Timmerman, Jan R. T. van Weering, August B. Smit, Marjo S. van der Knaap, Huibert D. Mansvelder, Mark H. G. Verheijen, Rogier Min
Publikováno v:
Kater, M S J, Baumgart, K F, Badia-Soteras, A, Heistek, T S, Carney, K E, Timmerman, A J, van Weering, J R T, Smit, A B, van der Knaap, M S, Mansvelder, H D, Verheijen, M H G & Min, R 2023, ' A novel role for MLC1 in regulating astrocyte–synapse interactions ', GLIA, vol. 71, no. 7, pp. 1770-1785 . https://doi.org/10.1002/glia.24368
Glia, 71(7), 1770-1785. John Wiley and Sons Inc.
GLIA, 71(7), 1770-1785. John Wiley and Sons Inc.
Kater, M S J, Baumgart, K F, Badia-Soteras, A, Heistek, T S, Carney, K E, Timmerman, A J, van Weering, J R T, Smit, A B, van der Knaap, M S, Mansvelder, H D, Verheijen, M H G & Min, R 2023, ' A novel role for MLC1 in regulating astrocyte–synapse interactions ', Glia, vol. 71, no. 7, pp. 1770-1785 . https://doi.org/10.1002/glia.24368
Glia, 71(7), 1770-1785. John Wiley and Sons Inc.
GLIA, 71(7), 1770-1785. John Wiley and Sons Inc.
Kater, M S J, Baumgart, K F, Badia-Soteras, A, Heistek, T S, Carney, K E, Timmerman, A J, van Weering, J R T, Smit, A B, van der Knaap, M S, Mansvelder, H D, Verheijen, M H G & Min, R 2023, ' A novel role for MLC1 in regulating astrocyte–synapse interactions ', Glia, vol. 71, no. 7, pp. 1770-1785 . https://doi.org/10.1002/glia.24368
Loss of function of the astrocyte membrane protein MLC1 is the primary genetic cause of the rare white matter disease Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC), which is characterized by disrupted brain ion and water homeostasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33cbe10cd35672d6014c75fbbae2d06
https://research.vumc.nl/en/publications/4a3453d2-881d-4b24-bf30-c4e9ae534160
https://research.vumc.nl/en/publications/4a3453d2-881d-4b24-bf30-c4e9ae534160
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10865
Tau aggregation is central to the pathogenesis of a large group of neurodegenerative diseases termed tauopathies, but it is still unclear in which way neurons respond to tau pathology and how tau accumulation leads to neurodegeneration. A striking ne
Autor:
Frederique J. Hafkamp, Rene A. Tio, Luuk C. Otterspoor, Tineke de Greef, Gijs J. van Steenbergen, Arjen R. T. van de Ven, Geert Smits, Hans Post, Dennis van Veghel
Publikováno v:
Heart Failure Reviews. 27:1683-1748
Heart failure (HF) is a major health concern, which accounts for 1–2% of all hospital admissions. Nevertheless, there remains a knowledge gap concerning which interventions contribute to effective prevention of HF (re)hospitalization. Therefore, th
Autor:
Aygul Subkhangulova, Miguel A. Gonzalez-Lozano, Alexander J. A. Groffen, Jan R. T. van Weering, August B. Smit, Ruud F. Toonen, Matthijs Verhage
Tomosyn is a large, non-canonical SNARE protein proposed to act as a competitive inhibitor of SNARE complex formation in vesicle exocytosis. In the brain, tomosyn inhibits fusion of synaptic vesicles (SVs), whereas its role in the fusion of neuropept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05abb6bf6d0dd1a5a2687f58508195b0
https://doi.org/10.1101/2022.12.18.520925
https://doi.org/10.1101/2022.12.18.520925