Výsledky vyhledávání - "R. T. Robertson"

Examination of a rodent limb bud micromass assay as a prescreen for developmental toxicity

Autor: J. O. Rundell, Robert L Clark, R. T. Robertson, L. D. Wise

Publikováno v: Teratology. 41:341-351

The mouse limb bud micromass assay is one of many short-term tests proposed as preliminary screens for potential developmental toxicity. Previous efforts to validate this assay have used too few "nonteratogens." The purpose of this study was to exami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c07ba0522423442581637226f56fc0f
https://doi.org/10.1002/tera.1420410312

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Do subplate neurons comprise a transient population of cells in developing neocortex of rats?

Autor: R T, Robertson, C M, Annis, J, Baratta, S, Haraldson, J, Ingeman, G H, Kageyama, E, Kimm, J, Yu

Publikováno v: The Journal of comparative neurology. 426(4)

Studies were undertaken to determine whether neurons of the subplate layer represent a transient or stable population of cells in developing neocortex of rat. The first set of studies sought to determine the fraction of subplate neurons that is lost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ac1044c1849e15171111c58d2bd0b7a
https://pubmed.ncbi.nlm.nih.gov/11027404

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Enhanced survival and morphological features of basal forebrain cholinergic neurons in vitro: role of neurotrophins and other potential cortically derived cholinergic trophic factors

Autor: D H, Ha, R T, Robertson, M, Roshanaei, J H, Weiss

Publikováno v: The Journal of comparative neurology. 406(2)

The present study examined survival- and growth-enhancing effects of cortical cells on basal forebrain cholinergic neurons (BFCNs) in culture and the degree to which endogenous nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad35cff7339515cbddb83aa31e16e27d
https://pubmed.ncbi.nlm.nih.gov/10096603

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Cultured basal forebrain cholinergic neurons in contact with cortical cells display synapses, enhanced morphological features, and decreased dependence on nerve growth factor

Autor: D H, Ha, R T, Robertson, C E, Ribak, J H, Weiss

Publikováno v: The Journal of comparative neurology. 373(3)

Prior studies examining the dependence of basal forebrain cholinergic neurons (BFCNs) on nerve growth factor (NGF) for survival have reached differing conclusions depending on the experimental paradigm employed, suggesting the importance of environme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f72bd149da45d73280ab5cd9804ab024
https://pubmed.ncbi.nlm.nih.gov/8889938

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Individual axon morphology and thalamocortical topography in developing rat somatosensory cortex

Autor: S M, Catalano, R T, Robertson, H P, Killackey

Publikováno v: The Journal of comparative neurology. 367(1)

The morphology of individual thalamocortical axons in developing rat primary somatosensory cortex was studied using lipophilic tracers. Anterograde labeling with lipophilic dyes demonstrated a topographical organization of thalamocortical projections

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b743850c8a14009b9c27f186515033d0
https://pubmed.ncbi.nlm.nih.gov/8867282

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Critical developmental periods for effects on male rat genitalia induced by finasteride, a 5 alpha-reductase inhibitor

Autor: Srinivasa Prahalada, Robert L Clark, Y. M. Leonard, J. L. Stevens, R. T. Robertson, E. A. Lochry, Charles A. Anderson, A. M. Hoberman

Publikováno v: Toxicology and applied pharmacology. 119(1)

The conversion of testosterone to 5 alpha-dihydrotestosterone by the enzyme 5 alpha-reductase is inhibited by finasteride. In a study in which maternal dosing with finasteride commenced on Gestational Day 15 and terminated on Postpartum Day 21, there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00aa062950ac6efd21e584855c02a020
https://pubmed.ncbi.nlm.nih.gov/8385814

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Decreased fertility in male rats administered the 5 alpha-reductase inhibitor, finasteride, is due to deficits in copulatory plug formation

Autor: Joseph M. Antonello, Srinivasa Prahalada, Mark A. Cukierski, James S. MacDonald, L. D. Wise, R. T. Robertson, J.L. Sina

Publikováno v: Reproductive toxicology (Elmsford, N.Y.). 5(4)

Oral administration of 80 mg/kg/day of finasteride, a potent specific inhibitor of 5α-reductase, to sexually mature male Sprague-Dawley rats for 24 to 38 weeks caused an approximate 30% to 40% decrease in fertility. There were no effects on mating i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d16ef9bdaa294af9a835364db9b77e5
https://pubmed.ncbi.nlm.nih.gov/1666858

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Effects of seminal vesicle and coagulating gland ablation on fertility in rats

Autor: Mark A. Cukierski, J.L. Sina, Srinivasa Prahalada, R. T. Robertson

Publikováno v: Reproductive toxicology (Elmsford, N.Y.). 5(4)

In rats the secretions of the seminal vesicles and coagulating glands clot after ejaculation in the female tract to form a copulatory plug. The plug plays a critical role in transcervical sperm transport. Factors that influence the secretions of acce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef5d20db21bbdc45cc6e82a3ab5ff8f
https://pubmed.ncbi.nlm.nih.gov/1806140

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