Výsledky vyhledávání - "R. T. Kawahata"

Improved pharmacokinetics and tumor localization of immunotoxins constructed with the Mr 30,000 form of ricin A chain

Autor: P W, Trown, D T, Reardan, S F, Carroll, J B, Stoudemire, R T, Kawahata

Publikováno v: Cancer research. 51(16)

The two naturally occurring forms of ricin A chain, Mr 33,000 and Mr 30,000 (RTA33 and RTA30) have been purified, and their chemical compositions, toxicities, and tissue distributions have been determined. As reported previously, the in vitro and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1854e0c28a3fb20a40e2c773efdfc34c
https://pubmed.ncbi.nlm.nih.gov/1868442

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The use of surface tension measurements in the design of antibody-based product formulations

Autor: H L, Levine, T C, Ransohoff, R T, Kawahata, W C, McGregor

Publikováno v: Journal of parenteral science and technology : a publication of the Parenteral Drug Association. 45(3)

Many proteins in aqueous solution are susceptible to interfacial denaturation and precipitation during mechanical agitation. With the large number of protein parenteral products currently in research or clinical testing, it is important not only to u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad27844ebe0a9a069d7132b8170889db
https://pubmed.ncbi.nlm.nih.gov/1886046

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Specific inhibition of in vitro lymphocyte transformation by an anti-pan T cell (gp67) ricin A chain immunotoxin

Autor: N A Kernan, R W Knowles, M J Burns, H E Broxmeyer, L Lu, H M Lee, R T Kawahata, P J Scannon, B Dupont

Publikováno v: The Journal of Immunology. 133:137-146

The toxin A chain of ricin has been conjugated by a disulfide bond to a murine monoclonal antibody that recognizes the gp67kD antigen present on 95% of peripheral T lymphocytes. The immunotoxin retains both functions of its component parts: it binds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7ea7ec91babe09385b3888e6bd1a7bc
https://doi.org/10.4049/jimmunol.133.1.137

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Monoclonal antibodies and immobilized antibodies

Autor: Robert J. Linhardt, C. W. Abell, R. M. Denney, B. W. Altrock, R. Auerbach, S. D. Bernal, R. E. Canfield, P. H. Ehrlich, W. R. Moyle, T. S. Chan, T. W. Chang, N. T. Chang, J. A. Cidlowski, M. D. Viceps, R. J. Cote, D. M. Morrissey, A. N. Houghton, E. J. Beattie, H. F. Oettgen, L. J. Old, C. M. Croce, R. S. Cubicciotti, A. E. Karu, R. M. Krauss, J. S. Cullor, A. Deutsch, H. Brandwein, H. Platt, D. M. Hunter, A. Dubitsky, S. M. Durham, F. A. Dolbeare, J. W. Gray, G. R. Dreesman, C. E. Kendall, J. C. Egrie, A. R. Frackelton, H. N. Eisen, A. H. Ross, S. Gay, G. Geirnaert, J. E. Geltosky, E. H. Goldberg, E. Goldwasser, C. Kavinsky, T. L. Weiss, H. G. Gratzner, B. Hampar, M. Zweig, S. D. Showalter, H. H. Handley, M. C. Glassy, Y. Hagiwara, H. Hagiwara, C. M. Huang, S. N. Cohen, J. V. Hughes, E. M. Scolnick, J. E. Tomassini, R. Jefferis, J. Steensgaard, H. S. Kaplan, N. N. H. Teng, K. S. Earn, R. F. Calvo, L. Kass, J. R. Kettman, M. V. Norgard, M. B. Khazaeli, W. H. Beierwaltes, B. G. England, P. C. Kung, G. Goldstein, L. Lanier, J. Phillips, N. L. Warner, J. W. Larrick, A. R. Raubitschek, K. E. Truitt, H. Lazarus, J. F. Schwaber, J. Lewicki, C. Lewis, J. V. Olander, W. R. Tolbert, E. L. Milford, C. B. Carpenter, J. M. Paradysz, D. F. Mosher, J. L. Mulshine, J. D. Minna, K. A. Murray, D. M. Neville, R. J. Youle, M. Nicolson, I. Pastan, M. C. Willingham, D. J. Fitzgerald, A. Pucci, A. M. Smithyman, M. B. Slade, P. W. French, G. Wijffels, C. S. Pukel, K. O. Lloyd, L. R. Travassos, W. G. Dippold, R. P. Reckel, J. L. Harris, R. Wellerson, S. M. Shaw, P. M. Kaplan, E. L. Reinherz, S. F. Schlossman, S. C. Mener, J. Sakamoto, C. C. Cordon, E. Friedman, C. L. Finstad, W. E. Enker, M. R. Melamed, J. F. Oettgen, P. J. Scannon, L. E. Spitler, H. M. Lee, R. T. Kawahata, R. P. Mischak, J. Schlom, D. Colcher, M. Nuti, P. H. Hand, F. Austin, G. D. Shockman, D. E. Jackson, W. Wong, Z. Steplewski, H. Koprowski, M. Herlyn, M. Strand, I. S. Trowbridge, D. L. Urdal, C. J. March, S. K. Dower, J. R. Wands, V. R. Zurawski, C. A. White, R. Dulbecco, W. R. Allen, E. C. Arnold, M. Flasher, H. H. Freedman, T. D. Heath, P. Shek, D. Papahadjopoulos, M. Ikeda, S. Sakamoto, K. Suzuki, M. Kuboyama, Y. Harada, A. Kawashiri, E. Takahashi, H. S. Lee, S. Margel, R. C. Nowinski, A. S. Hoffman, J. W. Peterson, K. B. Platt, D. E. Reed, F. X. Real, M. J. Mattes, P. O. Livingston, A. Rembaum, R. C. K. Yen, R. Rosenstein, B. Schneider

Publikováno v: Applied Biochemistry and Biotechnology. 15:53-80

Antibodies in both their free and immobilized state have been the object of considerable industrial and academic interest. A variety of methods are used for preparing and immobilizing antibodies. Applications for monoclonal antibodies include the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53b3e2a60fa089ffc4619eece666554b
https://doi.org/10.1007/bf02798506

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Effect of N-trifluoroacetyladriamycin-14-valerate on [3H]thymidine uptake and DNA synthesis of human lymphoma cells

Autor: R T Kawahata, Linda F. Chuang, M Israel, Ronald Y. Chuang

Publikováno v: Journal of Biological Chemistry. 258:1062-1065

The effects of N-trifluoroacetyladriamycin-14-valerate on the uptake of [3H]thymidine and its incorporation into DNA of human P3HR-1 lymphoma cells were studied. In the absence of the drug, at 0 degrees C, [3H]thymidine was transported into the cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c403069f73fea972a3b3cd91f5c41dc8
https://doi.org/10.1016/s0021-9258(18)33159-4

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Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate

Autor: R T, Kawahata, L F, Chuang, C A, Holmberg, B I, Osburn, R Y, Chuang

Publikováno v: Cancer research. 43(8)

6-Mercaptopurine was found to inhibit the growth of cultured human lymphoma P3HR-1 cells and the incorporation of [3H]-uridine into trichloroacetic acid-precipitable materials of the cells. One of the derivatives of 6-mercaptopurine, 6-mercaptopurine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b32c7a4f878f4291459cb6a82c09bbb8
https://pubmed.ncbi.nlm.nih.gov/6683125

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Effect of 6-mercaptopurine ribonucleotides on DNA-dependent RNA polymerase activity

Autor: R T, Kawahata, C A, Holmberg, B I, Osburn, L F, Chuang, R Y, Chuang

Publikováno v: Molecular pharmacology. 18(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1fef8d936f155a5cef19a106e0ac2ee
https://pubmed.ncbi.nlm.nih.gov/7007865

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Purification of monoclonal antibodies from mouse ascites eliminates contaminating infectious mouse type C viruses and nucleic acids

Autor: J A, Levy, H M, Lee, R T, Kawahata, L E, Spitler

Publikováno v: Clinical and experimental immunology. 56(1)

We examined the fate of infectious mouse type C viruses (MuLV) and nucleic acids during the purification of monoclonal antibodies (MoAbs) from mouse ascites. Hybridoma cell lines and their cell fluids can contain infectious ecotropic and xenotropic M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77bb629439eadd5f78e11bd7cc6d5762
https://pubmed.ncbi.nlm.nih.gov/6201307

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