Zobrazeno 1 - 10
of 15
pro vyhledávání: '"R. T. Hay"'
Autor:
R T, Hay
Publikováno v:
Ernst Schering Research Foundation workshop. (57)
Conjugation of ubiquitin-like proteins (Ubls) to components of the transcriptional machinery represents an important mechanism to allow switching between different activity states. While ubiquitin modification of transcription factors is associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f7974229ada19eaaafa832360c06be5
https://pubmed.ncbi.nlm.nih.gov/16568955
https://pubmed.ncbi.nlm.nih.gov/16568955
Publikováno v:
Current topics in microbiology and immunology. 272
Replication of the adenovirus genome is catalysed by adenovirus DNA polymerase in which the adenovirus preterminal protein acts as a protein primer. DNA polymerase and preterminal protein form a heterodimer which, in the presence of the cellular tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c48b7b0e3cf87fa6f457175997210413
https://pubmed.ncbi.nlm.nih.gov/12747549
https://pubmed.ncbi.nlm.nih.gov/12747549
Publikováno v:
Molecular and cellular biology. 21(10)
Transcriptional activation of NF-kappaB is mediated by signal-induced phosphorylation and degradation of its inhibitor, IkappaBalpha. NF-kappaB activation induces a rapid resynthesis of IkappaBalpha which is responsible for postinduction repression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::702283832786485975d6732707c6a619
https://pubmed.ncbi.nlm.nih.gov/11313474
https://pubmed.ncbi.nlm.nih.gov/11313474
Publikováno v:
FEBS letters. 455(3)
Activation of transcription factor NF-kappaB is accomplished by degradation of its inhibitor IkappaBalpha. Signal induced phosphorylation of IkappaBalpha on serine 32 and 36 targets the protein for ubiquitination on lysine 21 and 22. Here we use a ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26439a07593a9e6a4404967c0f9e3e3b
https://pubmed.ncbi.nlm.nih.gov/10437795
https://pubmed.ncbi.nlm.nih.gov/10437795
Publikováno v:
The Journal of biological chemistry. 274(10)
IkappaBalpha controls the transcriptional activity of nuclear factor (NF)-kappaB by retaining it in the cytoplasm; but, when expressed in the nucleus, it can also inhibit the interaction of NF-kappaB with DNA and promote the export of NF-kappaB from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::938059f4e448aeb897b44fbee95a5244
https://pubmed.ncbi.nlm.nih.gov/10037782
https://pubmed.ncbi.nlm.nih.gov/10037782
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 1 (2021)
ABSTRACT Bloodstream infections are a major cause of morbidity and mortality and result in significant costs to health care systems. Rapid identification of the causative agent of bloodstream infections is critical for patient treatment and improved
Externí odkaz:
https://doaj.org/article/edcb877a2e464507815144db9c4abd4f
Publikováno v:
Molecular cell. 2(2)
Activation of NF-kappaB is achieved by ubiquitination and proteasome-mediated degradation of IkappaBalpha. We have detected modified IkappaBalpha, conjugated to the small ubiquitin-like protein SUMO-1, which is resistant to signal-induced degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23e94b623a8b83fef1d10effdc478518
https://pubmed.ncbi.nlm.nih.gov/9734360
https://pubmed.ncbi.nlm.nih.gov/9734360
Publikováno v:
Oncogene. 16(16)
The molecular mechanisms underlying Hodgkin's disease remain obscure, but it has been recognized that the neoplastic cells display high levels of constitutively active nuclear NF-kappaB. Here we demonstrate that although nuclear NF-kappaB is transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aca1796f7ae5979eea48b7515c3be3e3
https://pubmed.ncbi.nlm.nih.gov/9572494
https://pubmed.ncbi.nlm.nih.gov/9572494
Publikováno v:
Molecular and cellular biology. 16(11)
NF-(kappa)B is an inducible transcription factor that activates many cellular genes involved in stress and immune response and whose DNA binding activity and cellular distribution are regulated by I(kappa)B inhibitor proteins. The interaction between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50d3b1e995a2775264c4e02e4ecc481f
https://pubmed.ncbi.nlm.nih.gov/8887676
https://pubmed.ncbi.nlm.nih.gov/8887676
Autor:
M, Roff, J, Thompson, M S, Rodriguez, J M, Jacque, F, Baleux, F, Arenzana-Seisdedos, R T, Hay
Publikováno v:
The Journal of biological chemistry. 271(13)
In unstimulated cells, the transcription factor NF-kappaB is held in the cytoplasm in an inactive state by the inhibitor protein IkappaBalpha. Stimulation of cells results in rapid phosphorylation and degradation of IkappaBalpha, thus releasing NF-ka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fbc32e6498107e045bd8d55dd312e16
https://pubmed.ncbi.nlm.nih.gov/8631829
https://pubmed.ncbi.nlm.nih.gov/8631829