Výsledky vyhledávání - "R. T. Gazzinelli"

Autor: U, Agero, L G, Mesquita, B R A, Neves, R T, Gazzinelli, O N, Mesquita

Publikováno v: Microscopy Research and Technique. 65:159-165

Transparent objects (phase objects) are not visible in a standard brightfield optical microscope. In order to see such objects the most used technique is phase-contrast microscopy. In phase-contrast microscopy the contrast observed is proportional to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63413bb73b99b8cfc55a9228b4b3257
https://doi.org/10.1002/jemt.20117

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Glycoconjugates isolated from Trypanosoma cruzi but not from Leishmania species membranes trigger nitric oxide synthesis as well as microbicidal activity in IFN-gamma-primed macrophages

Autor: M M Camargo, A C Andrade, I C Almeida, L R Travassos, R T Gazzinelli

Publikováno v: The Journal of Immunology. 159:6131-6139

In the present study, we investigated the role of glycosylphosphatidylinositol-anchored mucin-like glycoproteins (GPI-mucins) from Trypanosoma cruzi trypomastigotes in triggering the synthesis of nitric oxide as well as the microbicidal activity in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c4cdd8778074c95c92f14c93165e291
https://doi.org/10.4049/jimmunol.159.12.6131

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Genes for chemokines MuMig and Crg-2 are induced in protozoan and viral infections in response to IFN-gamma with patterns of tissue expression that suggest nonredundant roles in vivo

Autor: D Amichay, R T Gazzinelli, G Karupiah, T R Moench, A Sher, J M Farber

Publikováno v: The Journal of Immunology. 157:4511-4520

MuMig and Crg-2 are IFN-inducible murine chemokines whose human homologues, HuMig and IP-10, respectively, share activity in vitro as T cell chemoattractants. We analyzed the expression of the genes Mumig, crg-2, and IFN-gamma during experimental inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f77bf3f29c384aa22df3ccdd0c24812c
https://doi.org/10.4049/jimmunol.157.10.4511

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In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection

Autor: T M Scharton-Kersten, T A Wynn, E Y Denkers, S Bala, E Grunvald, S Hieny, R T Gazzinelli, A Sher

Publikováno v: The Journal of Immunology. 157:4045-4054

The relationship between IFN-gamma and IL-12 in generating innate immune responses and resistance to acute Toxoplasma gondii infection was assessed in T. gondii-exposed IFN-gamma knockout (gko) mice. Gko mice, in contrast to wild-type (wt) animals, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9f0291d3fdb1583db961259f8945ca7
https://doi.org/10.4049/jimmunol.157.9.4045

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HIV infection suppresses type 1 lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite-induced monokines

Autor: R T Gazzinelli, S Bala, R Stevens, M Baseler, L Wahl, J Kovacs, A Sher

Publikováno v: The Journal of Immunology. 155:1565-1574

Individuals infected with Toxoplasma gondii normally develop resistance to the parasite, resulting in an asymptomatic chronic infection. In AIDS patients, this resistance is lost leading to reactivation of infection and development of encephalitis. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9a757ed16e01cecd5311fb5535bb677
https://doi.org/10.4049/jimmunol.155.3.1565

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IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-gamma

Autor: P Zhou, M C Sieve, J Bennett, K J Kwon-Chung, R P Tewari, R T Gazzinelli, A Sher, R A Seder

Publikováno v: The Journal of Immunology. 155:785-795

Histoplasma capsulatum is a pathogenic fungus found in discrete geographic locations throughout the world. The fungus invades the reticuloendothelial organs such as the spleen and liver of immunocompetent hosts where it is usually controlled. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ef09405eaa7e947a33fb2661df0af4e
https://doi.org/10.4049/jimmunol.155.2.785

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Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation

Autor: R T Gazzinelli, I Eltoum, T A Wynn, A Sher

Publikováno v: The Journal of Immunology. 151:3672-3681

C57BL/6 mice infected with the ME-49 strain of Toxoplasma gondii develop a progressive encephalitis culminating in 100% mortality between 12 and 15 wk after intraperitoneal inoculation of the parasite. Moreover, when injected at 4 wk after infection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86ac4dfe0732f09e47b04fc1af08202a
https://doi.org/10.4049/jimmunol.151.7.3672

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Toxoplasma gondii induces a T-independent IFN-gamma response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-alpha

Autor: A Sher, I P Oswald, S Hieny, R T Gazzinelli

Publikováno v: The Journal of Immunology. 150:3982-3989

Spleen cells from scid mice produce high levels of IFN-gamma when exposed to either live tachyzoites of Toxoplasma gondii or a soluble parasite extract. Small numbers of parasites are sufficient to stimulate this response, which is also induced by ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::139d25a526cbb8fcd73d792c0fc27006
https://doi.org/10.4049/jimmunol.150.9.3982

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IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity

Autor: I P Oswald, R T Gazzinelli, A Sher, S L James

Publikováno v: The Journal of Immunology. 148:3578-3582

After activation with IFN-gamma, thioglycollate-elicited murine peritoneal macrophages kill schistosomula of Schistosoma mansoni in vitro by an L-arginine-dependent mechanism which involves the production of reactive nitrogen oxides (NO). In the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b717f2e1da9bd4558ed65799093b55fd
https://doi.org/10.4049/jimmunol.148.11.3578

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