Zobrazeno 1 - 10
of 181
pro vyhledávání: '"R. T. Cullen"'
Publikováno v:
Inhalation Toxicology. 14:685-703
Cellulose fibers, along with many other organic fibers, are durable. Therefore, if inhaled, they have the potential to persist within the lung, and may then cause disease. Here we report the effects of injecting high-purity cellulose fibers into the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c6939fd99d4f4e387f3461551a046d
https://doi.org/10.1080/08958370290084584
https://doi.org/10.1080/08958370290084584
Publikováno v:
Scopus-Elsevier
This article describes the activity of an E-glass microfiber (104E) during chronic inhalation and intraperitoneal injection studies in rats. Results are compared with another microfiber of similar dissolution rate (k(dis)), code 100/475, and the more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743b0d6cbac1a3838eff7b483158242a
https://doi.org/10.1080/08958370050138012
https://doi.org/10.1080/08958370050138012
Publikováno v:
Scopus-Elsevier
In this article the volumetric overload hypothesis, which predicts the impairment of clearance of particles deposited in the lung in terms of particle volume, is reevaluated. The degree to which simple expressions of retained lung burden explain pulm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b0040dbcb507bf7e7ded2b378b2e94
https://doi.org/10.1080/08958370050166796
https://doi.org/10.1080/08958370050166796
Publikováno v:
Journal of Applied Toxicology. 20:49-60
The inflammatory effects of respirable cellulose fibres were studied in two short-term animal models: intraperitoneal injection in mice, and inhalation in rats. The mouse peritoneal cavity is particularly sensitive to fibrous compared to non-fibrous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5869df35cada9ad4aa871320995f984
https://doi.org/10.1002/(sici)1099-1263(200001/02)20:1<49::aid-jat627>3.0.co
https://doi.org/10.1002/(sici)1099-1263(200001/02)20:1<49::aid-jat627>3.0.co
Publikováno v:
The Annals of Occupational Hygiene. 43:143-153
The study objectives were to assess the ability of intratracheal injection methods to discriminate between nine fibre types in respect of pulmonary biopersistence, and to provide approximate estimates of relative biopersistence and durability for a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a78adc26f739f26f49de4d4415260c36
https://doi.org/10.1016/s0003-4878(99)00017-4
https://doi.org/10.1016/s0003-4878(99)00017-4
Publikováno v:
The Annals of Occupational Hygiene. 41:123-133
Recent animal studies have demonstrated three separate and distinct mechanisms by which low toxicity dusts can cause important chronic pulmonary effects; through overloading of clearance mechanisms, through increased toxicity associated with ultrafin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4e8130334a3b8f5e7b49e11a6efd2a
https://doi.org/10.1016/s0003-4878(96)00014-2
https://doi.org/10.1016/s0003-4878(96)00014-2
Publikováno v:
Environmental Health Perspectives
A wide range of fiber types was tested in two in vitro assays: toxicity to A549 epithelial cells, as detachment from substrate, and the production of the proinflammatory cytokine tumor necrosis factor (TNF) by rat alveolar macrophages. Three of the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50515e82761d994f6d91029820b018c8
http://europepmc.org/articles/PMC1470121
http://europepmc.org/articles/PMC1470121
Publikováno v:
Thorax. 47:1050-1055
BACKGROUND: Inhalation of fumes from heated colophony (pine resin) is a recognised cause of occupational asthma, although the mechanisms by which colophony produces symptoms are unclear and specific immune responses to colophony have not been reporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3d86775534692dc11397987108fff5
https://doi.org/10.1136/thx.47.12.1050
https://doi.org/10.1136/thx.47.12.1050
Publikováno v:
The Annals of Occupational Hygiene.
Cellulose fibres are used to manufacture productssuch as textiles, paper and cardboard, to give struc-tural strength to cement and other construction prod-ucts and to insulate buildings. This manufacture anduse can produce respirable airborne cellulo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::846944ee4d0d3afaf03e5d3123648f04
https://doi.org/10.1093/annhyg/46.suppl_1.81
https://doi.org/10.1093/annhyg/46.suppl_1.81
Publikováno v:
The Annals of Occupational Hygiene.
Previous results from the Colt Fibre Research Programme supported the idea that the number of long thin fibres and their ability to persist in the lung are predictors for the risk of cancer. The results were based on nine fibres, including one glass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b3b4b7bf8e19d846dbdf687c6826c72
https://doi.org/10.1093/annhyg/46.suppl_1.77
https://doi.org/10.1093/annhyg/46.suppl_1.77