Zobrazeno 1 - 10
of 13
pro vyhledávání: '"R. T. A. Macgillivray"'
Publikováno v:
Publons
Scopus-Elsevier
Scopus-Elsevier
When amino acids Pro60B, Pro60C, and Trp60D are deleted from thrombin, the resulting mutant (des-PPW) exhibits (compared to the wild-type enzyme): a similar second order rate constant of inhibition (k(on)) for diisopropyl fluorophosphate, and a compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0dc1f8bbed73d3918085f1b4f96cb78
https://doi.org/10.1016/s0021-9258(17)46734-2
https://doi.org/10.1016/s0021-9258(17)46734-2
Publikováno v:
Journal of Biological Chemistry. 267:2971-2978
Lack of availability of a primary structure for bovine factor V has hindered detailed analysis of a vast majority of structure-function correlations on this molecule. To determine the primary structure of bovine factor V, we used liver mRNA as a temp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e999945fce4155c3236c07c0000c863b
https://doi.org/10.1016/s0021-9258(19)50682-2
https://doi.org/10.1016/s0021-9258(19)50682-2
Autor:
J. Eibl, N Barrett, P. L. Turecek, A Mitterer, F G Falkner, Kistner O, W Bodemer, F Dorner, S Kandels, F Scheiflinger, R T A MacGillivray
Publikováno v:
Thrombosis and Haemostasis. 68:119-124
SummaryWe have worked out an efficient and time saving procedure for the expression of recombinant human prothrombin. The glycoprotein was expressed in the vaccinia virus expression system in several mammalian cell lines. The kidney cell lines Vero a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e85170108f773f064e26b789c1208c8
https://doi.org/10.1055/s-0038-1656335
https://doi.org/10.1055/s-0038-1656335
Publikováno v:
Publons
Residue 39 of serine proteases neighbors positions P'2 to P'4 of the substrate. When Glu-39 of thrombin is replaced with Lys, the resultant enzyme (E39K) retains similar P1, P2, and P3 specificities but has altered P'3 and/or P'4 specificities. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db835ea6d49a5446d0e9ea6771dfc84
https://doi.org/10.1016/s0021-9258(18)92771-7
https://doi.org/10.1016/s0021-9258(18)92771-7
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 6(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eae8a5ee4a48dd16b47e419caedbb2a
https://pubmed.ncbi.nlm.nih.gov/18485091
https://pubmed.ncbi.nlm.nih.gov/18485091
Autor:
M. Serizawa, Y. Takahashi, Z. L. Harris, Jonathan D. Gitlin, H. Miyajima, R. T. A. Macgillivray
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 92(7)
Ceruloplasmin is an abundant alpha 2-serum glycoprotein that contains 95% of the copper found in the plasma of vertebrate species. We report here on the identification of a genetic defect in the ceruloplasmin gene in a patient previously noted to hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70bfd4d989cdf73c7e76d653413bd14
https://pubmed.ncbi.nlm.nih.gov/7708681
https://pubmed.ncbi.nlm.nih.gov/7708681
Publikováno v:
Recombinant Technology in Hemostasis and Thrombosis ISBN: 9781461366447
The development of recombinant DNA techniques during the past ten years has led to an explosion of the field of molecular genetics. Using these techniques, DNA fragments can be cloned and characterized at the molecular level. This in turn led to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99e35aa7847cf485e7eaf421a6253922
https://doi.org/10.1007/978-1-4615-3698-7_2
https://doi.org/10.1007/978-1-4615-3698-7_2
Autor:
I. Clark-Lewis, R. W. Colman, R. T. A. Macgillivray, H. Saito, R. A. Pixley, D. E. Cool, Hélène C. F. Côté, Bryan J. Clarke
Publikováno v:
Journal of Biological Chemistry. 264:11497-11502
We have localized the binding epitope(s) of two murine monoclonal antibodies (B7C9 and P5-2-1) that were shown previously to inhibit the activation of human coagulation factor XII by negatively charged surfaces. A factor XII cDNA expression library i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e89f32772fd78be6f6f4f200e658c03
https://doi.org/10.1016/s0021-9258(18)60491-0
https://doi.org/10.1016/s0021-9258(18)60491-0
Publikováno v:
Oral Presentations.
Radioactive cDNA was synthesized from a bovine liver mRNA preparation enriched for fibrinogen mRNA activity. This cDNA was used in a solution hybridization assay to screen a collection of recombinant plasmids carrying bovine cDNA inserts. A number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e64daeb30ae55a068d5d03d9ab5d9dc
https://doi.org/10.1055/s-0038-1652265
https://doi.org/10.1055/s-0038-1652265
Autor:
D. H. Van Thiel, M. A. Giambrone, S. J. Schwarzenberg, R. Kirschner, I. H. Scheinberg, I. Sternlieb, R. T A MacGillivray, Marlys L. Koschinsky, Mark J. Czaja, N. F. LaRusso, Francis R. Weiner, Mark A. Zern
Deficiency of serum ceruloplasmin is a characteristic biochemical abnormality of Wilson's disease, although the mechanism of this finding is unknown. Ceruloplasmin messenger RNA (mRNA) levels were therefore examined in five patients with Wilson's dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d7e2ff3097b012a7dbe2d24592f326
https://europepmc.org/articles/PMC442366/
https://europepmc.org/articles/PMC442366/