Zobrazeno 1 - 10
of 30
pro vyhledávání: '"R. Stanley McElhinney"'
Autor:
Guohui Sun, Peiying Bai, Tengjiao Fan, Lijiao Zhao, Rugang Zhong, R. Stanley McElhinney, T. Brian H. McMurry, Dorothy J. Donnelly, Joan E. McCormick, Jane Kelly, Geoffrey P. Margison
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2170 (2023)
O6-methylguanine-DNA methyltransferase (MGMT) constitutes an important cellular mechanism for repairing potentially cytotoxic DNA damage induced by guanine O6-alkylating agents and can render cells highly resistant to certain cancer chemotherapeutic
Externí odkaz:
https://doaj.org/article/d48b616a82e846a4806c37a6666ca7ba
Publikováno v:
ARKIVOC, Vol 2003, Iss 7, Pp 180-189 (2003)
Externí odkaz:
https://doaj.org/article/da104ef46a4944c79fa2dd3d0e6cbb44
Autor:
Geoffrey P. Margison, T. Brian H. McMurry, R. Stanley McElhinney, Robert Brown, Malcolm Ranson, Vincent A. Barvaux
Temozolomide is an alkylating agent that mediates its cytotoxic effects via O6-methylguanine (O6-meG) adducts in DNA and their recognition and processing by the postreplication mismatch repair system (MMR). O6-meG adducts can be repaired by the DNA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aba4fe058932adc997be2d0cec5f709
https://doi.org/10.1158/1535-7163.c.6531875
https://doi.org/10.1158/1535-7163.c.6531875
Autor:
Geoffrey P. Margison, T. Brian H. McMurry, R. Stanley McElhinney, Robert Brown, Malcolm Ranson, Vincent A. Barvaux
Figure 2 from Dual repair modulation reverses Temozolomide resistance in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16df0979b6f37b44b17e26d9e7b09ac3
https://doi.org/10.1158/1535-7163.22485290
https://doi.org/10.1158/1535-7163.22485290
Autor:
Sergio Lopez, Isabel Rozas, R. Stanley McElhinney, Geoffrey P. Margison, T. Brian H. McMurry, Alessandra Cordeiro
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:1658-1665
Searching for a novel family of inactivators of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) which is known to bind to the DNA minor groove, we have computationally modelled and synthesised two series of 2-amino-6-aryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e213f3fff53cbc3e7c957f462b4dd2ac
https://doi.org/10.1016/j.bmc.2011.01.038
https://doi.org/10.1016/j.bmc.2011.01.038
Autor:
Nicola Glynn, R. Stanley McElhinney, Takayuki Shibata, Geoffrey P. Margison, T. Brian H. McMurry, David M. Williams
Publikováno v:
Nucleic Acids Research
The human DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) dealkylates mutagenic O6-alkylguanine lesions within DNA in an irreversible reaction which results in inactivation of the protein. MGMT also provides resistance of tumours to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee70bd67f3e0ed9ba0919a2417f35d88
https://doi.org/10.1093/nar/gkl117
https://doi.org/10.1093/nar/gkl117
Autor:
Malcolm R Ranson, T. Brian H. McMurry, R. Stanley McElhinney, Martin J Dawson, Siow Ming Lee, Helen McGrath, J Bridgewater, L Gumbrell, Mark R Middleton, Geoffrey P. Margison, Dorothy Josephine Donnelly, Sue Waller, Debra Jowle, Gavin Halbert
Publikováno v:
Clinical Cancer Research. 12:1577-1584
Purpose: A major mechanism of resistance to temozolomide involves the DNA repair protein O6-alkylguanine-DNA-alkyltransferase (ATase). The main aims of this phase I trial were to determine an ATase-depleting dose (ADD) of lomeguatrib, a potent pseudo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde10c57e9db41a7dfa6b677c78520e0
https://doi.org/10.1158/1078-0432.ccr-05-2198
https://doi.org/10.1158/1078-0432.ccr-05-2198
Publikováno v:
Synthesis. :983-988
A convenient and simple method is described for formally transferring a phthaloyl protecting group from one amino group to another in an unsymmetrical diamine. The NMR spectra of some of the amido intermediates reveal that, at room temperature, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0ee12dffd2085b045607ccc7966d979
https://doi.org/10.1055/s-2006-926362
https://doi.org/10.1055/s-2006-926362
Autor:
Vincent A. Barvaux, Malcolm Ranson, Robert Brown, R. Stanley McElhinney, T. Brian H. McMurry, Geoffrey P. Margison
Publikováno v:
Molecular Cancer Therapeutics. 3:123-127
Temozolomide is an alkylating agent that mediates its cytotoxic effects via O6-methylguanine (O6-meG) adducts in DNA and their recognition and processing by the postreplication mismatch repair system (MMR). O6-meG adducts can be repaired by the DNA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::314e9f80823e8e3504e9f6164223aec6
https://doi.org/10.1158/1535-7163.123.3.2
https://doi.org/10.1158/1535-7163.123.3.2
Publikováno v:
Tetrahedron Letters. 50:6022-6024
2-Amino-4,6-dichloro-5-nitropyrimidine is an intermediate required for the preparation of nitropyrimidines as inactivators of the DNA repairing protein MGMT. When attempting its synthesis, 2-amino-4,5,6-trichloropyrimidine is obtained instead, via un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba03d46463b007d0413deff204a6c006
https://doi.org/10.1016/j.tetlet.2009.08.029
https://doi.org/10.1016/j.tetlet.2009.08.029