Zobrazeno 1 - 10
of 13
pro vyhledávání: '"R. Spencer Tong"'
Autor:
Vinothkumar Rajan, Nicole Melong, Wing Hing Wong, Benjamin King, R. Spencer Tong, Nithin Mahajan, Daniel Gaston, Troy Lund, David Rittenberg, Graham Dellaire, Clinton J.V. Campbell, Todd Druley, Jason N. Berman
Publikováno v:
Haematologica, Vol 105, Iss 10 (2019)
Xenograft models are invaluable tools in establishing the current paradigms of hematopoiesis and leukemogenesis. The zebrafish has emerged as a robust alternative xenograft model but, like mice, lack specific cytokines that mimic the microenvironment
Externí odkaz:
https://doaj.org/article/732605c4586348e6ac1df48e0a742dd0
Publikováno v:
Haematologica, Vol 104, Iss 12 (2019)
Nearly all adults harbor acute myeloid leukemia (AML)-related clonal hematopoietic mutations at a variant allele fraction (VAF) of ≥0.0001, yet relatively few develop hematologic malignancies. We conducted a nested analysis in the Nurses’ Health
Externí odkaz:
https://doaj.org/article/fd320ddfdebe4dc29044e68096162544
Autor:
R. Spencer Tong, Robert B. Gerbing, Todd A. Alonzo, Jeffrey W. Taub, Jim Wang, Lisa Eidenschink Brodersen, Reuven J. Schore, Maureen M. O'Brien, Amy Heerema-McKenney, Jason N. Berman, Shelton A Viola, Michael R. Loken, E. Anders Kolb, Betsy A. Hirsch, Alan S. Gamis, Karen M. Chisholm, Susana C. Raimondi, Nobuko Hijiya, Amy Beckman, Johann Hitzler, Todd E. Druley
Publikováno v:
Blood. 138:2337-2346
Myeloid leukemia in children with Down syndrome (ML-DS) is associated with young age and somatic GATA1 mutations. Because of high event-free survival (EFS) and hypersensitivity of the leukemic blasts to chemotherapy, the prior Children’s Oncology G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09340fb26ba3d69a872971ec1b2e4b9
https://doi.org/10.1182/blood.2021012206
https://doi.org/10.1182/blood.2021012206
Autor:
Carol Wise, Darren K. Johnson, Lilian Antunes, Cathleen L. Raggio, Todd E. Druley, Conner Jenkins, Mark A. Seeley, R. Spencer Tong, Nephi A. Walton, Nancy H. Miller, Matthew T. Oetjens, Jose A. Morcuende, Xavier Bledsoe, Christina A. Gurnett, Gabe Haller, Brooke Sadler, Ina E Amarillo, Matthew B. Dobbs, Yared H. Kidane, Philip F. Giampietro, Troy Jenkins
Publikováno v:
Journal of Medical Genetics. 56:427-433
IntroductionAdolescent idiopathic scoliosis (AIS) is a common musculoskeletal disorder with strong evidence for a genetic contribution. CNVs play an important role in congenital scoliosis, but their role in idiopathic scoliosis has been largely unexp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fadeac2be52dbf977b9c38bae98fc8
https://doi.org/10.1136/jmedgenet-2018-105877
https://doi.org/10.1136/jmedgenet-2018-105877
Autor:
Nicole Melong, Clinton J. V. Campbell, Troy C. Lund, Wing Hing Wong, Todd E. Druley, Nitin Mahajan, Benjamin King, Vinothkumar Rajan, R. Spencer Tong, David Rittenberg, Daniel Gaston, Jason N. Berman, Graham Dellaire
Publikováno v:
Haematologica
Xenograft models are invaluable tools in establishing the current paradigms of hematopoiesis and leukemogenesis. The zebrafish has emerged as a robust alternative xenograft model but, like mice, lacks specific cytokines that mimic the microenvironmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922a651c648d7839bca442c0d314559e
http://europepmc.org/articles/PMC7556680
http://europepmc.org/articles/PMC7556680
Publikováno v:
Haematologica
Nearly all adults harbor acute myeloid leukemia-related clonal hematopoietic mutations at a variant allele fraction of ≥0.0001, yet relatively few develop hematologic malignancies. We conducted a nested analysis in the Nurses' Health Study and Heal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cadb2cf51de7d89b8a100aad6595dfa
https://ora.ox.ac.uk/objects/uuid:0b8e253e-e539-4ee3-83aa-c86c374eb8cd
https://ora.ox.ac.uk/objects/uuid:0b8e253e-e539-4ee3-83aa-c86c374eb8cd
Publikováno v:
Journal of Visualized Experiments. 138(2018)
Conventional next-generation sequencing techniques (NGS) have allowed for immense genomic characterization for over a decade. Specifically, NGS has been used to analyze the spectrum of clonal mutations in malignancy. Though far more efficient than tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08174cde5f738009d84e335f7d4d259
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
R. Spencer Tong, Elisabeth R. Wilson
Publikováno v:
Minimal Residual Disease Testing ISBN: 9783319948263
Children with Down syndrome (DS) have an increased risk of developing myeloid leukemia of Down syndrome (ML-DS). This disease is preceded by a self-limiting, preleukemic condition known as transient myeloproliferative disease (TMD). While most DS neo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8c3a43b33885130250f129c7c88c2fe
https://doi.org/10.1007/978-3-319-94827-0_5
https://doi.org/10.1007/978-3-319-94827-0_5
Autor:
Brooke, Sadler, Gabe, Haller, Lilian, Antunes, Xavier, Bledsoe, Jose, Morcuende, Philip, Giampietro, Cathleen, Raggio, Nancy, Miller, Yared, Kidane, Carol A, Wise, Ina, Amarillo, Nephi, Walton, Mark, Seeley, Darren, Johnson, Conner, Jenkins, Troy, Jenkins, Matthew, Oetjens, R Spencer, Tong, Todd E, Druley, Matthew B, Dobbs, Christina A, Gurnett
Publikováno v:
Journal of medical genetics. 56(7)
INTRODUCTION: Adolescent idiopathic scoliosis (AIS) is a common musculoskeletal disorder with strong evidence for a genetic contribution. Copy number variants (CNVs) play an important role in congenital scoliosis, but their role in idiopathic scolios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6bce11cce7d3c512d5a9fdbd29a52422
https://pubmed.ncbi.nlm.nih.gov/30803986
https://pubmed.ncbi.nlm.nih.gov/30803986
Autor:
D. Katherine Grange, Kathleen S. Jay, Jason N. Berman, Wing Hing Wong, David R. O'Leary, Todd E. Druley, Johann K. Hitzler, R. Spencer Tong
Publikováno v:
Blood. 132:3839-3839
Introduction: Children with Down syndrome (DS) have a 150-fold higher risk of developing myeloid leukemia (ML-DS) (Wechsler J, Nat Gen 2002). Ten percent (10%) of DS children are also predisposed to developing a preleukemic self-limiting condition, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::640d7e0acdcace4f088d9df8223e3e00
https://doi.org/10.1182/blood-2018-99-120168
https://doi.org/10.1182/blood-2018-99-120168