Zobrazeno 1 - 10
of 107
pro vyhledávání: '"R. Shorthouse"'
Autor:
Jaideep J. Pandit, A. D. Smith, A Rashid, Frédéric Ris, J. R. Shorthouse, Martijn P. Gosselink, N. A. Crabtree, Ian Lindsey, K. J. Gorissen
Publikováno v:
Colorectal Disease. 19(7)
Aim Advances in laparoscopic techniques combined with enhanced recovery pathways have led to faster recuperation and discharge after colorectal surgery. Peripheral nerve blockade using transversus abdominis plane (TAP) blocks reduce opioid requiremen
Publikováno v:
Transplant Immunology. 10:1-14
The antiproliferative effects of MMF are believed to be the mechanism of its immunosuppressive action. We further investigated the mechanisms of action by assessing the pharmacodynamics (PD) of MMF in treated animals using whole blood assays not only
Autor:
R. Shorthouse, Gerald J. Berry, Timothy R. Brazelton, Randall E. Morris, Hermann Reichenspurner, Bruce A. Reitz, Michael Nitschke, Vipal Soni, X. Huang
Publikováno v:
Transplantation. 64:373-383
BACKGROUND The purpose of this study was to investigate whether obliterative bronchiolitis might occur after xenogenic pulmonary transplantation. A model for obliterative airway disease (OAD) after tracheal allograft transplantation in the rat underg
Autor:
Norman Briffa, H. T. Silva, Timothy R. Brazelton, Margaret E. Billingham, Jason R. Chan, Randall E. Morris, R. Shorthouse
Publikováno v:
Xenotransplantation. 11(2)
Like allografts, vascularized xenografts are susceptible to a process of chronic rejection. We have used the hamster-to-rat aortic transplant model to study characteristics of this phenomenon and to determine whether it could be controlled or prevent
Autor:
R. Shorthouse, Teun van Gelder, Katrin Boeke, Jan Gummert, Margaret E. Billingham, Markus J. Barten, Randall E. Morris
Publikováno v:
American Journal of Transplantation, 2(8), 719-732. Wiley-Blackwell Publishing Ltd
The primary mechanism of action in vivo of mycophenolate mofetil (MMF) is believed to be inhibition of lymphocyte proliferation. We used novel assays of lymphocyte functions (pharmacodynamics, PD) in whole blood collected from rat heart allograft rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374250ce20cd5708d35f1690b508a5cc
https://pure.eur.nl/en/publications/0f8119e6-0dbc-4d48-9285-e0935788dd4e
https://pure.eur.nl/en/publications/0f8119e6-0dbc-4d48-9285-e0935788dd4e
Publikováno v:
Journal of immunological methods. 253(1-2)
We have optimized assays to measure mitogen-stimulated rat lymphocyte activation in whole blood and have used these assays to quantitate the potencies of immunosuppressive drugs with different mechanisms of action. To define the optimal conditions fo
Autor:
T. van Gelder, Katrin Boeke, Jan Gummert, Randall E. Morris, R. Shorthouse, Markus J. Barten, Margaret E. Billingham
Publikováno v:
Transplantation proceedings. 33(3)
Publikováno v:
Transplantation proceedings. 33(3)
WHOLE BLOOD ASSAYS are preferred because they better approximate the complex in vivo relationships among drug concentration, the binding of drug to plasma constituents and cellular targets, and the interaction among immune cells and their products. A
Publikováno v:
Transplantation. 69(11)
Background. Obliterative bronchiolitis remains a major long-term complication after lung transplantation. Using a reproducible model of heterotopically transplanted rat tracheas, this study examined the role of several novel immunosuppresive compound
Autor:
J. R. Shorthouse, C. M. Danbury
Publikováno v:
Anaesthesia. 64:693-694