Zobrazeno 1 - 10
of 146
pro vyhledávání: '"R. Shiman"'
Publikováno v:
Economic Inquiry. 57:1497-1509
In a dynamic investment framework with depreciation, we show incumbent satellite operators have incentives to “warehouse” a fraction of their assigned spectrum and orbital slots, keeping nonoperational assets in place, which reduces output, incre
Publikováno v:
Journal of Molecular Biology. 390:791-804
Many RNA tertiary structures are stable in the presence of monovalent ions alone. To evaluate the degree to which ions at or near the surfaces of such RNAs contribute to stability, the salt-dependent stability of a variety of RNA structures was measu
Autor:
David E. Draper, R. Shiman
Publikováno v:
Journal of Molecular Biology. 302:79-91
The effects of monovalent cations (Li(+), Na(+), K(+), Rb(+), Cs(+), and NH4(+)) on the thermal stability of RNA tertiary structure were investigated by UV melting. We show that with the RNA used here (nucleotides 1051-1108 of Escherichia coli 23 S r
Autor:
Douglas W. Gray, R. Shiman
Publikováno v:
Journal of Biological Chemistry. 273:34760-34769
Tyrosine in an hepatocyte is transported from the plasma, synthesized from phenylalanine, or released during protein turnover. Effects of phenylalanine and tyrosine on the formation and fate (partitioning) of tyrosine from the different sources were
Autor:
R. Shiman, Lyndon J. Mitnaul
Publikováno v:
Proceedings of the National Academy of Sciences. 92:885-889
This work had two purposes: (i) to determine in vivo whether liver phenylalanine hydroxylase (PAH) is regulated by its substrates phenylalanine and tetrahydrobiopterin (BH4) as studies with purified enzyme suggest and (ii) to investigate in vivo the
Publikováno v:
Journal of Biological Chemistry. 269:24647-24656
Activation by phenylalanine and reduction by the co-factor (6R)-tetrahydrobiopterin (BH4) are required for formation of active liver phenylalanine hydroxylase. This work describes effects of the activation and redox state on substrate and effector re
Publikováno v:
Journal of Biological Chemistry. 269:24657-24665
Effects of phenylalanine and di- and tetrahydropterins on presteady-state and steady-state catalytic behavior of rat liver phenylalanine hydroxylase are analyzed. From this and previous work (Shiman, R, Xia, T., Hill, M., and Gray, D.(1994) J. Biol.
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:1140-1143
Agar dilution MIC testing of amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin against 496 beta-lactamase-producing anaerobic gram-negative rods revealed MICs for 90% of the strains tested of 256.0 (amoxicilli
Autor:
Daniel R. Shiman
Publikováno v:
SSRN Electronic Journal.
Sutton has developed a new theory of endogenous sunk costs, which predicts that industries with significant endogenous sunk costs will have a lower bound on concentration even as they grow in output. Endogenous sunk costs are fixed costs that firms c
Autor:
Daniel R. Shiman
Publikováno v:
SSRN Electronic Journal.
To explain why many manufacturing industries have remained highly concentrated, John Sutton has developed a new theory of endogenous sunk costs which predicts that industries with significant endogenous sunk costs will have a lower bound on concentra