Zobrazeno 1 - 10
of 218
pro vyhledávání: '"R. Scott Hansen"'
Autor:
Xinxian Deng, Di Kim Nguyen, R Scott Hansen, Daniel L Van Dyke, Stanley M Gartler, Christine M Disteche
Publikováno v:
PLoS Genetics, Vol 5, Iss 12, p e1000751 (2009)
In mammals, dosage compensation is achieved by doubling expression of X-linked genes in both sexes, together with X inactivation in females. Up-regulation of the active X chromosome may be controlled by DNA sequence-based and/or epigenetic mechanisms
Externí odkaz:
https://doaj.org/article/c1b192e3ec6d4888af3ae0ee325eb015
Autor:
Ross C. Hardison, Bing Ren, John A. Stamatoyannopoulos, Tyrone Ryba, Michael Snyder, Benjamin D. Pope, Vishnu Dileep, Yanli Wang, Feng Yue, Jonathan H. Dennis, Günhan Gülsoy, Yong Cheng, Theresa K. Canfield, Weisheng Wu, Robert E. Thurman, Daniel L. Vera, Tamer Kahveci, James Taylor, David M. Gilbert, Olgert Denas, R. Scott Hansen
Publikováno v:
Nature
Eukaryotic chromosomes replicate in a temporal order known as the replication-timing program. In mammals, replication timing is cell-type-specific with at least half the genome switching replication timing during development, primarily in units of 40
Autor:
Amber A. Burt, Ian E. Alexander, David W. Russell, Anda M. Cornea, Chia Lin Wei, R. Scott Hansen, David R. Deyle, Richard Sandstrom, John A. Stamatoyannopoulos, Li B. Li
Publikováno v:
Nature structural & molecular biology
To determine which genomic features promote homologous recombination, we created a genome-wide map of gene targeting sites. An adeno-associated virus vector was used to target identical loci introduced as transcriptionally active retroviral vector pr
Autor:
Licia Selleri, Thalia Papayannopoulou, Robert E. Thurman, Sandra Stehling-Sun, R. Scott Hansen, Douglas Dunn, Eric Rynes, Alexander Y. Rudensky, Mark Groudine, Rajinder Kaul, Audra K. Johnson, Arthur I. Skoultchi, Richard Sandstrom, Peter J. Sabo, Morgan Diegel, Marella F. T. R. de Bruijn, Daniel Bates, Steven Z. Josefowicz, Evan E. Eichler, Jeff Vierstra, Michaël Bender, Eric Haugen, Piper M. Treuting, Rachel Byron, Robert M. Samstein, Theresa K. Canfield, Miaohua Zhang, Matthew S. Wilken, Erika Giste, Kai Hsin Chang, Shinny Vong, Stuart H. Orkin, Fidencio Neri, Kristen Lee, Richard Humbert, Thomas A. Reh, John A. Stamatoyannopoulos
Publikováno v:
Vierstra, J; Rynes, E; Sandstrom, R; Zhang, M; Canfield, T; Scott Hansen, R; et al.(2014). Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science, 346(6212), 1007-1012. doi: 10.1126/science.1246426. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3hh233xj
Science (New York, N.Y.), vol 346, iss 6212
Science (New York, N.Y.), vol 346, iss 6212
© 2014 by the American Association for the Advancement of Science; all rights reserved. To study the evolutionary dynamics of regulatory DNA, we mapped >1.3 million deoxyribonuclease I-hypersensitive sites (DHSs) in 45 mouse cell and tissue types, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45833cb70075af1e58eb4d7be4358038
https://ora.ox.ac.uk/objects/uuid:db4c1d75-7682-4e65-8ea3-e600e7d57604
https://ora.ox.ac.uk/objects/uuid:db4c1d75-7682-4e65-8ea3-e600e7d57604
Autor:
Hongzhu Qu, Peter J. Sabo, Steven F. Ziegler, Ian A. Glass, Rajinder Kaul, Shelly Heimfeld, Shamil R. Sunyaev, Eric Rynes, Jennifer A. Brody, Tanya Kutyavin, R. Scott Hansen, Chris Cotsapas, Daniel Bates, Robert E. Thurman, Matthew T. Maurano, Shane Neph, Anthony Shafer, Sandra Stehling-Sun, Nona Sotoodehnia, Eric Haugen, Fidencio Neri, Theresa K. Canfield, Erika Giste, Richard Sandstrom, Morgan Diegel, Antony Raubitschek, Hao Wang, Audra K. Johnson, Kristen Lee, Alex Reynolds, Richard Humbert, John A. Stamatoyannopoulos
Publikováno v:
Science. 337:1190-1195
Predictions of Genetic Disease Many genome-wide association studies (GWAS) have identified loci and variants associated with disease, but the ability to predict disease on the basis of these genetic variants remains small. Maurano et al. (p. 1190 ; s
Autor:
Vishwanath R. Iyer, Lingyun Song, Michael O. Dorschner, Joshua M. Akey, Andrew B. Stergachis, Kristen Lee, Anthony Shafer, Shinny Vong, Amartya Sanyal, Hongzhu Qu, Audra K. Johnson, Ericka M. Johnson, Kavita Garg, Minerva E. Sanchez, Daniel Bates, Benjamin Vernot, George Stamatoyannopoulos, Tanya Kutyavin, Robert E. Thurman, Patrick A. Navas, Douglas Dunn, Eric Rynes, Bryan R. Lajoie, Matthew T. Maurano, Jeff Vierstra, Molly Weaver, Jason D. Lieb, Sam John, Alexias Safi, Lisa Boatman, Shane Neph, Zhancheng Zhang, Yongqi Yan, Bum Kyu Lee, Dimitra Lotakis, Zhuzhu Zhang, Gregory E. Crawford, Tristan Frum, Abigail K. Ebersol, Richard Sandstrom, Theresa K. Canfield, Eric Haugen, Erika Giste, Job Dekker, Muneesh Tewari, Alex Reynolds, Eric D. Nguyen, Fidencio Neri, Richard Humbert, Peter J. Sabo, Morgan Diegel, John A. Stamatoyannopoulos, Vaughn Roach, Hao Wang, Rajinder Kaul, Terrence S. Furey, Nathan C. Sheffield, R. Scott Hansen, Jeremy M. Simon, Shamil R. Sunyaev, Boris Lenhard, Darin London
Publikováno v:
Nature
DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, insulators, silencers and locus control regions. Here we present the first
Autor:
Michael J. MacCoss, Mark Groudine, Molly Weaver, Tanya Kutyavin, John A. Stamatoyannopoulos, Shane Neph, Daniel Bates, Eric Rynes, Benjamin Vernot, Douglas Dunn, Anthony Schafer, Joshua M. Akey, Peter J. Sabo, Jeff Vierstra, Robert E. Thurman, R. Scott Hansen, Andrew B. Stergachis, Rajinder Kaul, Shinny Vong, Alex Reynolds, Theresa K. Canfield, Richard Humbert, Erika Giste, Jun Neri, Michaël Bender, Miaohua Zhang, Kristen Lee, Rachel Byron, Richard Sandstrom, Sam John, Eric Haugen, Gayathri Balasundaram, Vaughn Roach, Morgan Diegel, Hao Wang, Audra K. Johnson, Matthew T. Maurano
Publikováno v:
Nature
Regulatory factor binding to genomic DNA protects the underlying sequence from cleavage by DNase I, leaving nucleotide-resolution footprints. Using genomic DNase I footprinting across 41 diverse cell and tissue types, we detected 45 million transcrip
Autor:
Atsushi Shibata, Penny A. Jeggo, Holly Brunton, Aaron A. Goodarzi, Angela T. Noon, R. Scott Hansen, Amruta Shrikhande
Publikováno v:
Molecular and Cellular Biology. 31:4022-4035
Heterochromatin (HC) poses a barrier to γH2AX focus expansion and DNA double-strand break (DSB) repair, the latter being relieved by ATM-dependent KAP-1 phosphorylation. Using high-resolution imaging, we show here that the HC superstructure markedly
Autor:
Michael O. Dorschner, Theresa K. Canfield, Stanley M. Gartler, Robert E. Thurman, Sean Thomas, Molly Weaver, Richard Sandstrom, R. Scott Hansen, John A. Stamatoyannopoulos
Publikováno v:
Proceedings of the National Academy of Sciences. 107:139-144
Faithful transmission of genetic material to daughter cells involves a characteristic temporal order of DNA replication, which may play a significant role in the inheritance of epigenetic states. We developed a genome-scale approach—Repli Seq—to
Publikováno v:
Biochemical Genetics. 45:761-767
Polymerase chain reaction (PCR) has become the mainstay of DNA sequence analysis. Yet there is always uncertainty concerning the source of the template DNA that gave rise to a particular PCR product. The risks of contamination, biased amplification,