Zobrazeno 1 - 10
of 18
pro vyhledávání: '"R. Scott Bitner"'
Autor:
Stella Markosyan, Kennan C. Marsh, R. Scott Bitner, Rich Radek, Karla Drescher, Jerry J. Buccafusco, Arthur L. Nikkel, William H. Bunnelle, Murali Gopalakrishnan, David J. Anderson, Michael W. Decker, Kaitlin E. Browman, Kathy L. Kohlhaas
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:875-886
We previously reported that alpha7 nicotinic acetylcholine receptor (nAChR) agonism produces efficacy in preclinical cognition models correlating with activation of cognitive and neuroprotective signaling pathways associated with Alzheimer's disease
Autor:
Kaitlin E. Browman, Arthur L. Nikkel, Richard Harris, Monika Håkerud, William H. Bunnelle, Paul J. Brackemeyer, David J. Anderson, Jennifer M. Frost, Sabine Halm, Jens Halvard Grønlien, Eva Spies, Liping Pan, Eric A.G. Blomme, Clark A. Briggs, Rosalind J. Helfrich, Ryan M. Fryer, Karla Drescher, Earl J. Gubbins, R. Scott Bitner, Ruth L. Martin, Kennan C. Marsh, Kirsten Thorin-Hagene, Stephani Otte, Peter Curzon, Murali Gopalakrishnan, John Malysz, Michael Meyer, Devalina Law, Gerard B. Fox, Hilde Ween, Dagmar Bury, Karin R. Tietje, Hongyu Xu, Pamela S. Puttfarcken, Angela L. Molesky, Kathy L. Kohlhaas, Holly M. Robb, Jeffrey F. Waring, Richard J. Radek
Publikováno v:
CNS Drug Reviews. 14:65-82
Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the alpha7 subtype is highly expressed in the hippocampus and cortex and is thought to play important roles in a variety of cognitive processes. In this review, we describe the pro
Autor:
Joseph P. Mikusa, Peter R. Hollingsworth, Robert B. Moreland, Brenda Martino, R. Scott Bitner, Gin C. Hsieh
Publikováno v:
Pharmacology Biochemistry and Behavior. 81:797-804
A series of in vivo studies in a conscious rat model was conducted to investigate the role of oxytocinergic and dopaminergic neurotransmission in the central regulation of penile erection. Oxytocin, when administrated either intracerebroventricularly
Autor:
Lynne E. Rueter, Gerard B. Fox, Kaitlin E. Browman, Arthur A. Hancock, Ramin Faghih, Timothy A. Esbenshade, Jill M. Wetter, Richard J. Radek, Min Zhang, James P. Sullivan, Michael J. Buckley, Kennan C. Marsh, Victoria A. Komater, Jia Bao Pan, Holly M. Miner, Martine Lemaire, Betty B. Yao, Kathleen M. Krueger, Roger D. Porsolt, Michael E. Ballard, Karla Drescher, Marlon D. Cowart, Michael W. Decker, Youssef L. Bennani, R. Scott Bitner
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 313:176-190
Acute pharmacological blockade of central histamine H 3 receptors (H 3 Rs) enhances arousal/attention in rodents. However, there is little information available for other behavioral domains or for repeated administration using selective compounds. AB
Autor:
Betty B. Yao, Ramin Faghih, Michael W. Decker, Youssef L. Bennani, Gerard B. Fox, Richard J. Radek, Timothy A. Esbenshade, R. Scott Bitner, Michael Williams, Arthur A. Hancock, Angela M. Lewis, Jia Bao Pan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 305:897-908
Pharmacological blockade of central histamine H3 receptors (H3Rs) enhances cognition in rodents and offers promise for the clinical treatment of neurological disorders. However, many previously characterized H3R antagonists are either not selective f
Autor:
Arthur A. Hancock, Youssef L. Bennani, Gerard B. Fox, Chae Hee Kang, R. Scott Bitner, Arthur L. Nikkel, Michael W. Decker, Ramin Faghih, Lawrence A. Black, Timothy A. Esbenshade, Thomas R. Miller, Jia Bao Pan
Publikováno v:
Pharmacology Biochemistry and Behavior. 72:741-750
The selective H(3) receptor agonist (R)-alpha-methylhistamine [(R)-alpha-MeHA] stimulates drinking in the adult rat. In the present study, we investigated the role of the H(3) receptor in mediating this behavior in a new dipsogenia model using the CD
Autor:
Mark W. Holladay, Michael Williams, Theresa A. Kuntzweiler, Pamela S. Puttfarcken, Diana L. Donnelly-Roberts, Clark A. Briggs, Anthony W. Bannon, Peter Curzon, Stephen P. Arneric, Michael W. Decker, Arthur L. Nikkel, R. Scott Bitner
Publikováno v:
Journal of Physiology-Paris. 92:221-224
ABT-594, a nicotinic acetylcholine receptor agonist, has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of ABT-594 into the nucleus raphe magnus (NRM) is antinociceptive in a therma
Autor:
Thomas R. Miller, Karla Drescher, Arthur A. Hancock, Timothy A. Esbenshade, Kennan C. Marsh, James P. Sullivan, Gerard B. Fox, Kaitlin E. Browman, Jorge D. Brioni, James S. Polakowski, Marlon D. Cowart, Thomas A. Fey, Kathleen M. Krueger, Chen Zhao, Holly M. Robb, Richard J. Radek, Lynne E. Rueter, Victoria Komater-Roderwald, R. Scott Bitner, Min Zhang
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 343(1)
Blockade of the histamine H(3) receptor (H(3)R) enhances central neurotransmitter release, making it an attractive target for the treatment of cognitive disorders. Here, we present in vitro and in vivo pharmacological profiles for the H(3)R antagonis
Autor:
R. Scott Bitner
Publikováno v:
Biochemical pharmacology. 83(6)
CREB-mediated transcription can be initiated by membrane receptor stimulation and subsequent activation of intracellular pathways to the cell nucleus, and has been described as a molecular switch required for learning and memory. While CREB dimers ar
Autor:
Marina I. Strakhova, Peer B. Jacobson, Elizabeth A. Cronin, Wilfried Hornberger, Stella Markosyan, Michael E. Brune, Victoria A. Roderwald, Kaitlin E. Browman, Rohde Jeffrey J, Eric G. Mohler, Karla Drescher, Lynne E. Rueter, R. Scott Bitner
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(14)
Mounting evidence suggests excessive glucocorticoid activity may contribute to Alzheimer's disease (AD) and age-associated memory impairment. 11β-hydroxysteroid dehydrogenase type-1 (HSD1) regulates conversion of glucocorticoids from inactive to act