Zobrazeno 1 - 10
of 95
pro vyhledávání: '"R. Sanguedolce"'
Autor:
A. Calascibetta, Flavia Contino, S. Feo, G. Gulotta, M. Cajozzo, A. Antona, G. Sanguedolce, R. Sanguedolce
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and it is the target for the 5-Fluorouracil (5-FU) activity. Barbour et al. showed that variant structural forms of TS in tumour cell lines confer resistance to fluoropyrimidines. We pla
Externí odkaz:
https://doaj.org/article/2284fe57696243859265ca02b9fa81be
Publikováno v:
Journal of Chemotherapy. 23:354-357
Many drugs can be used for adjuvant therapy of breast cancer, including anthracyclines, cyclophosphamide, 5-fluorouracil (5-fU) and, recently, taxanes (TXT) have shown promising results. 5-FU blocks thymidylate synthase (TS) which cross-links p53 mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc46ec4a0c87147aeb9cbfb948e94795
https://doi.org/10.1179/joc.2011.23.6.354
https://doi.org/10.1179/joc.2011.23.6.354
Autor:
A. Calascibetta, R. Sanguedolce, Daniela Cabibi, Aragona F, J. Dispenza, Fabio Fulfaro, Antonino Martorana, M. R. Valerio, M. Brandi
10546 Background: Adjuvant chemotherapy is used in the treatment of breast carcinoma independently of axillar node involvement. Different drug combinations such as CMF, FAC, FEC are still used; recently new drugs such as TXT (NEJM 332:1004,1997) show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acad482e793968359ab741627013513
http://hdl.handle.net/10447/20882
http://hdl.handle.net/10447/20882
Publikováno v:
Tumori Journal. 77:219-226
In view of the structural similarity of mitoxantrone to anthracyclines and its ability to intercalate into DNA, we studied its influence on the synthetic processes of DNA and proteins in CD-1 mice tissues. By studying at the DNA level the impairment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c7a832f28c808bd4fe2c83b3251414
https://doi.org/10.1177/030089169107700307
https://doi.org/10.1177/030089169107700307
Autor:
Luciano Rausa, Anna Martorana, A. Calascibetta, F Aragona, Elisabetta Barresi, R. Sanguedolce, Daniela Cabibi
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 25(9-11)
Breast cancer is a heterogeneous disease, so therapeutic predictive biological markers need to be identified. To date an accurate evaluation of predictive markers is mainly done at the primary site; however, the main goal of adjuvant therapy for brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef5e1c557084f55522e96f758690009
https://pubmed.ncbi.nlm.nih.gov/17065089
https://pubmed.ncbi.nlm.nih.gov/17065089
Autor:
R. Sanguedolce, Alessandra Alaimo, Valeria Carina, Melchiorre Cervello, Natale D'Alessandro, Annamaria Maurici, Paola Poma, Manuela Labbozzetta, Antonella Cusimano, Monica Notarbartolo
Publikováno v:
Scopus-Elsevier
We tested the novel NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) in the hepatic cancer (HCC) HepG2, HA22T/VGH and HuH-6 cells. The sensitivity to the cell growth inhibitory and apoptotic effects of the agent increased along with the lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61acaea615f4533cb7cd24bccccccf6
https://doi.org/10.3892/ijo.28.4.923
https://doi.org/10.3892/ijo.28.4.923
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 23(8-9)
5-Fluorouracil (5FU) is the main drug used for the treatment of colorectal cancer (CRC) and Thymidilate Synthase (TS) is its target enzyme. TS gene has regulatory tandemly repeated sequences in its 5'' and 3''untraslated region (5''-3'' UTR). CRC oft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8550d72b499df62ca2f14b54d557f9
https://pubmed.ncbi.nlm.nih.gov/15571262
https://pubmed.ncbi.nlm.nih.gov/15571262
Autor:
Sabine Merkelbach-Bruse, Volkmar H. J. Hans, Farzad Houshdaran, Micaela Mathiak, Josef Rüschoff, Lucia Gullotti, Reinhard Büttner, Riccardo Alessandro, R. Sanguedolce
Publikováno v:
Oncology Reports.
Microsatellite instability (MSI) is a characteristic feature of up to 15% of colorectal cancers (CRC) and is associated with better response to adjuvant chemotherapy with 5-fluorouracil (5-FU). In this study we have investigated the association betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d1af020d59d5c1f9635132f9c518c1
https://doi.org/10.3892/or.11.4.839
https://doi.org/10.3892/or.11.4.839
Autor:
Luciano Rausa, A. Calascibetta, R. Sanguedolce, Daniela Cabibi, Maria Campione, Aragona F, G. Dardanoni, Barresi E
Thymidylate Synthase (TS) is the key enzyme for DNA synthesis pathways and is inhibited by 5-fluorouracil (5FU). The aim of this work was to study TS expression and the proliferation rate in the different histological types of colorectal carcinoma (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eeded2ec1b74153e16c81422f091aca
http://hdl.handle.net/10447/4646
http://hdl.handle.net/10447/4646
Autor:
R. Sanguedolce, Michele Pavone-Macaluso, Carlo Pavone, Rosalinda Allegro, Vincenza Morello, Rosa Maria Tomasino, Marco Vella, Vincenzo Serretta, Rossana Porcasi
Publikováno v:
Journal of cancer research and clinical oncology. 129(8)
To study GP-170 in superficial bladder cancer at initial diagnosis and at recurrence and to evaluate if intravesical chemoprophylaxis modifies the expression of GP-170 in tumor recurrences. GP-170 was retrospectively assessed in 160 patients affected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df3509f087db76b47d4ab712e81e3e7
https://pubmed.ncbi.nlm.nih.gov/12884023
https://pubmed.ncbi.nlm.nih.gov/12884023