Výsledky vyhledávání

Leucine 10 allelic variant in signal peptide of PCSK9 increases the LDL cholesterol-lowering effect of statins in patients with familial hypercholesterolaemia

Autor: Stefano Bertolini, Livia Pisciotta, A. Wunsch, Sebastiano Calandra, Claudio Rabacchi, R. Sallo

Publikováno v: Nutrition, Metabolism and Cardiovascular Diseases. 22:831-835

Background and aims In the normal population, carriers of an additional leucine residue in a stretch of nine leucines in the signal peptide of PCSK9 (L10) have lower total (TC) and low-density lipoprotein cholesterol (LDL-C) than homozygotes for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c702cf9fd5907ac471c192032d512a
https://doi.org/10.1016/j.numecd.2011.04.003

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Characterization of three kindreds with familial combined hypolipidemia caused by loss-of-function mutations of ANGPTL3

Autor: Patrizia Tarugi, Sara Simonelli, R. Sallo, Guido Franceschini, Diego Ardigò, Sebastiano Calandra, Laura Calabresi, Stefano Bertolini, Elda Favari, Franco Bernini, Livia Pisciotta, Tatiana Fancello, Ivana Zavaroni, Maria Pia Adorni, Lucia Magnolo

Publikováno v: Circulation. Cardiovascular genetics. 5(1)

Background— Angiopoietin-like protein 3 (ANGPTL3) affects lipid metabolism by inhibiting the activity of lipoprotein and endothelial lipases. Angptl3 knockout mice have marked hypolipidemia, and heterozygous carriers of ANGPLT3 , loss-of-function m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c462abafe07adb3dfa45dd70331d90
https://pubmed.ncbi.nlm.nih.gov/22062970

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Akademický článek

First principles computation of composition dependent elastic constants of omega in titanium alloys: implications on mechanical behavior

Autor: R. Salloom, S. A. Mantri, R. Banerjee, S. G. Srinivasan

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)

Abstract For decades the poor mechanical properties of Ti alloys were attributed to the intrinsic brittleness of the hexagonal ω-phase that has fewer than 5-independent slip systems. We contradict this conventional wisdom by coupling first-principle

Externí odkaz: https://doaj.org/article/665d0be8afd14341a583d72997a039f0

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Characterization of RNA-binding proteins possibly involved in modulating human AT 1 receptor mRNA stability

Autor: J. David Port, Aldo Pende, G. Lotti, R. Sallo, Lidia Contini, Mario Passalacqua, Rasheeda Tanveer

Angiotensin II exerts its cardiovascular effects mainly through the activation of AT1 receptors. These receptors can be regulated at a post-transcriptional level, that is through the modulation of the mRNA stability. This regulation usually involves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b91a211b452683c4fb1bb4de59403b
https://hdl.handle.net/11567/330522

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Effect of ezetimibe coadministered with statins in genotype-confirmed heterozygous FH patients

Autor: Alfredo Cantafora, Livia Pisciotta, R. Fresa, R. Sallo, Isabella Colangeli, Stefano Bertolini, A. Bellocchio, L. Bocchi, Sebastiano Calandra, Tommaso Fasano

Publikováno v: Atherosclerosis. 194(2)

We investigated the effect of statins and statins plus ezetimibe in 65 FH heterozygotes carrying LDLR-defective or LDLR-negative mutations as well as the effect of ezetimibe monotherapy in 50 hypercholesterolemic (HCH) patients intolerant to statins.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8f87bd0b481139a5596f3bffddeb82
https://pubmed.ncbi.nlm.nih.gov/17140581

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Akademický článek

Composition-dependent apparent activation-energy and sluggish grain-growth in high entropy alloys

Autor: B. Gwalani, R. Salloom, T. Alam, S. G. Valentin, X. Zhou, G. Thompson, S. G. Srinivasan, R. Banerjee

Publikováno v: Materials Research Letters, Vol 7, Iss 7, Pp 267-274 (2019)

Experimental results reveal that the apparent activation-energy for grain-growth in an fcc-based AlxCoCrFeNi high entropy alloy (HEA) system increases from 179 to 486 kJ/mol when the Al content increases from x = 0.1 to 0.3. These unexpectedly high a

Externí odkaz: https://doaj.org/article/994b1245d7a64ff1a95a9aa9644c9044

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