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A novel human glycoprotein ACA is an upstream regulator of human hematopoiesis

Autor: F. J. Rodriguez-Jiménez, P. Rios, Z. A. Becker-Kojić, A. Romero, R. Saffrich, A. D. Ho, M. Stojković, Marta Rubio, J. R. Ureña-Peralta

Publikováno v: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

A central issue in stem cell biology is a better understanding of the molecular mechanisms that regulate self-renewal of human hematopoietic stem cells (HSCs). Control of the specific function of HSCs like self-renewal and differentiation might be re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228be4a38896817a53a8319663a47c16
https://pubmed.ncbi.nlm.nih.gov/24143385

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Assessing the Quality of Solution Nuclear Magnetic Resonance Structures by Complete Cross-Validation

Autor: Axel T. Brunger, Michael Nilges, Angela M. Gronenborn, R Saffrich, G M Clore

Publikováno v: Science. 261:328-331

Structure determination of macromolecules in solution by nuclear magnetic resonance (NMR) spectroscopy involves the fitting of atomic models to the observed nuclear Overhauser effect (NOE) data. Complete cross-validation has been used to define relia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe49ec6a934ee80ec1cd89aebc10ae24
https://doi.org/10.1126/science.8332897

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PAMAM structure-based multifunctional fluorescent conjugates for improved fluorescent labelling of biomacromolecules

Autor: G. Moldenhauer, E. M. Knapp, B. Wängler, Carmen Wängler, R. Saffrich, M. Schnölzer, Walter Mier, Uwe Haberkorn, Michael Eisenhut, Barbro Beijer

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 14(27)

Fluorescent probes are of increasing interest in medicinal and biological applications for the elucidation of the structures and functions of healthy as well as tumour cells. The quality of these investigations is determined by the intensity of the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2989ac7d13b39dc4f96858902dee5167
https://pubmed.ncbi.nlm.nih.gov/18752247

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Endocytosis of NBD-sphingolipids in neurons: exclusion from degradative compartments and transport to the Golgi complex

Autor: T, Babià, M D, Ledesma, R, Saffrich, J W, Kok, C G, Dotti, G, Egea

Publikováno v: Traffic (Copenhagen, Denmark). 2(6)

Sphingolipids are abundant constituents of neuronal membranes that have been implicated in intracellular signaling, neurite outgrowth and differentiation. Differential localization and trafficking of lipids to membrane domains contribute to the speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb0b83c8d8ab5074f848a4a0864d4d81
https://pubmed.ncbi.nlm.nih.gov/11389767

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Cover Picture: PAMAM Structure-Based Multifunctional Fluorescent Conjugates for Improved Fluorescent Labelling of Biomacromolecules (Chem. Eur. J. 27/2008)

Autor: E. M. Knapp, M. Schnölzer, Uwe Haberkorn, Carmen Wängler, Michael Eisenhut, R. Saffrich, Walter Mier, G. Moldenhauer, B. Wängler, Barbro Beijer

Publikováno v: Chemistry - A European Journal. 14:8043-8043

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e3e13ddbaeef72d3df61e5c02bd78c3
https://doi.org/10.1002/chem.200890107

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Melanoma targeting by melanocortin peptides: current status and future perspectives

Autor: S. Knecht, S. Froidevaux, H. Tanner, M. Calame‐Christe, M. Henze, J. Schuhmacher, R. Saffrich, A. N. Eberle

Publikováno v: Experimental Dermatology. 13:570-570

Melanoma tumour targeting was investigated with radiolabelled α-MSH peptides and with α-MSH derivatives attached to large carriers such as liposomes. The main focus of this paper will be current targeting concepts of melanoma (α-melanoma tumour di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4dc903688b3b46a7f8d832f1648454b
https://doi.org/10.1111/j.0906-6705.2004.00212l.x

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Expression of S100 proteins in normal human hematopoietic stem cells and in AML

Autor: A. D. Ho, R. Saffrich, A. Lenze, S. Leicht, X. Li, M. Lenze, T. Franz, H. Lannert, T. Able, V. Eckstein

Publikováno v: Journal of Clinical Oncology. 26:7072-7072

7072 Background: In the quest to reduce mortality and morbidity from cancer, there is continued effort to identify novel biomarkers to aid in the early detection and the accurate prediction of tumo...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e52cb15205ab236e8e34a7f2d9f8771
https://doi.org/10.1200/jco.2008.26.15_suppl.7072

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Different kinases acting on stathmin (oncoprotein, Op18) in human healthy and malignant hematopoietic stem cells

Autor: V. Eckstein, A. D. Ho, T. Franz, R. Saffrich, A. Lenze, H. Lannert, R. Hofmann, S. Leicht, T. Able, M. Lenze

Publikováno v: Journal of Clinical Oncology. 25:17527-17527

17527 Background: Stathmin/Op18 is a cytosolic phosphoprotein which regulates the dynamics of microtubules. This regulation is important in mitosis during cell division and in the migration of cells in modification of the cytoskeleton. The process of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4713cfa8c7deff23aa8808928c05688
https://doi.org/10.1200/jco.2007.25.18_suppl.17527

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