Zobrazeno 1 - 10
of 718
pro vyhledávání: '"R. SWINDELL"'
Autor:
William R. Swindell
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
IntroductionALS is a fatal neurodegenerative disease for which underlying mechanisms are incompletely understood. The motor neuron is a central player in ALS pathogenesis but different transcriptome signatures have been derived from bulk analysis of
Externí odkaz:
https://doaj.org/article/94111015edb74b539ef1fcb9f1d28de9
Autor:
Ranjitha Uppala, Mrinal K. Sarkar, Kelly Z. Young, Feiyang Ma, Pritika Vemulapalli, Rachael Wasikowski, Olesya Plazyo, William R. Swindell, Emanual Maverakis, Mehrnaz Gharaee-Kermani, Allison C. Billi, Lam C. Tsoi, J. Michelle Kahlenberg, Johann E. Gudjonsson
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108986- (2024)
Summary: Interferon (IFN) activity exhibits a gender bias in human skin, skewed toward females. We show that HERC6, an IFN-induced E3 ubiquitin ligase, is induced in human keratinocytes through the epidermal type I IFN; IFN-κ. HERC6 knockdown in hum
Externí odkaz:
https://doaj.org/article/87cba07b11fb49b59bbc593a99230d5e
Autor:
William R. Swindell, Krzysztof Bojanowski, Parvesh Singh, Manpreet Randhawa, Ratan K. Chaudhuri
Publikováno v:
JID Innovations, Vol 3, Iss 3, Pp 100178- (2023)
The endocannabinoid (eCB) system plays an active role in epidermal homeostasis. Phytocannabinoids such as cannabidiol modulate this system but also act through eCB-independent mechanisms. This study evaluated the effects of cannabidiol, bakuchiol (BA
Externí odkaz:
https://doaj.org/article/44e3e15b4f9543fea66d5a688e7846f8
Publikováno v:
Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 3, Pp 334-342 (2021)
Background: Cardiopulmonary resuscitation (CPR) is occurring more frequently at community hospitals but most patients undergoing CPR do not survive to discharge. Tools to predict CPR survival can be improved by the identification of high-yield clinic
Externí odkaz:
https://doaj.org/article/8199134282d94665840a47f6b5046080
Publikováno v:
Antioxidants, Vol 12, Iss 6, p 1168 (2023)
The cumulative damage skin sustains from exposure to environmental stressors throughout life exerts significant effects on skin aging and cancer development. One of the main ways by which environmental stressors mediate their effects within skin is t
Externí odkaz:
https://doaj.org/article/ab9dcf4cac504cf58f35e4af25dff506
Autor:
Lisa M. Godsel, Quinn R. Roth-Carter, Jennifer L. Koetsier, Lam C. Tsoi, Amber L. Huffine, Joshua A. Broussard, Gillian N. Fitz, Sarah M. Lloyd, Junghun Kweon, Hope E. Burks, Marihan Hegazy, Saki Amagai, Paul W. Harms, Xianying Xing, Joseph Kirma, Jodi L. Johnson, Gloria Urciuoli, Lynn T. Doglio, William R. Swindell, Rajeshwar Awatramani, Eli Sprecher, Xiaomin Bao, Eran Cohen-Barak, Caterina Missero, Johann E. Gudjonsson, Kathleen J. Green
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
Desmoglein 1 (Dsg1) is a cadherin restricted to stratified tissues of terrestrial vertebrates, which serve as essential physical and immune barriers. Dsg1 loss-of-function mutations in humans result in skin lesions and multiple allergies, and isolate
Externí odkaz:
https://doaj.org/article/d068468a139f45248652e5280fb391cf
Autor:
Krzysztof Bojanowski, Collins U. Ibeji, Parvesh Singh, William R. Swindell, Ratan K. Chaudhuri
Publikováno v:
JID Innovations, Vol 1, Iss 4, Pp 100040- (2021)
Dimethyl fumarate (DMF) is an effective oral treatment for psoriasis administered in Europe for nearly 60 years. However, its potential has been limited by contact dermatitis that prohibits topical application. This paper characterizes a DMF derivati
Externí odkaz:
https://doaj.org/article/5eb5aa453a134d53a05219274e2adbce
Autor:
Shuai Shao, Jiaoling Chen, William R. Swindell, Lam C. Tsoi, Xianying Xing, Feiyang Ma, Ranjitha Uppala, Mrinal K. Sarkar, Olesya Plazyo, Allison C. Billi, Rachael Wasikowski, Kathleen M. Smith, Prisca Honore, Victoria E. Scott, Emanual Maverakis, J. Michelle Kahlenberg, Gang Wang, Nicole L. Ward, Paul W. Harms, Johann E. Gudjonsson
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
Altered epidermal differentiation along with increased keratinocyte proliferation is a characteristic feature of psoriasis and pityriasis rubra pilaris (PRP). However, despite this large degree of overlapping clinical and histologic features, the mol
Externí odkaz:
https://doaj.org/article/b201715a6d7340b8bcc4b0a37d7e6e2f
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14307 (2022)
Atopic dermatitis (AD) is a chronic disease in which epidermal barrier disruption triggers Th2-mediated eruption of eczematous lesions. Topical emollients are a cornerstone of chronic management. This study evaluated efficacy of two plant-derived oil
Externí odkaz:
https://doaj.org/article/0ca5984235f543b4be2765b7dc5e469b
Autor:
William R. Swindell, Colin P. S. Kruse, Edward O. List, Darlene E. Berryman, John J. Kopchick
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-33 (2019)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a debilitating disease with few treatment options. Progress towards new therapies requires validated disease biomarkers, but there is no consensus on which fluid-based measures are most infor
Externí odkaz:
https://doaj.org/article/8ef25d2ce5c64d18b8bacb2a063e9dd9