Zobrazeno 1 - 10
of 23
pro vyhledávání: '"R. S. Geary"'
Publikováno v:
Journal of robotic surgery. 16(1)
This was a retrospective study to review the uptake and outcomes of robotic gynaecological surgery in England between 1st April 2006 and 31st March 2018, analysing Hospital Episode Statistics form National Health Service hospitals in England. Women a
Publikováno v:
Toxicological Sciences. 46:365-375
Autor:
R. S. Geary, Salomon A Stavchansky
Publikováno v:
Analytical Letters. 25:1843-1850
A simple gas liquid chromatographic procedure using flame ionization detection is described for the determination of almitrine bismesylate in intestinal fluid in the presence of 2-allylamino, 4-amino, 6-(4′, 4″-difluoro 1 benzhydryl 4-piperazinyl
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 2(10)
Antisense technology has progressed beyond the point of using only phosphorothioate oligodeoxynucleotides as therapeutic agents to looking at antisense molecules that contain additional chemical modifications as the next generation of therapeutic age
Autor:
C C, Cunningham, J T, Holmlund, R S, Geary, T J, Kwoh, A, Dorr, J F, Johnston, B, Monia, J, Nemunaitis
Publikováno v:
Cancer. 92(5)
Abnormal expression of Ras proteins frequently is found with oncogenic transformation making ras a promising therapeutic target. ISIS 2503 is a 20-base antisense phosphorothioate oligodeoxyribonucleotide that specifically downregulates H-ras expressi
Autor:
R S, Geary, O, Khatsenko, K, Bunker, R, Crooke, M, Moore, T, Burckin, L, Truong, H, Sasmor, A A, Levin
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(3)
Three modified 20-mer antisense oligonucleotides targeted to human intercellular adhesion molecule-1 mRNA were characterized for their presystemic stability and oral bioavailability compared with a first-generation phosphorothioate oligodeoxynucleoti
Autor:
R S, Geary, T A, Watanabe, L, Truong, S, Freier, E A, Lesnik, N B, Sioufi, H, Sasmor, M, Manoharan, A A, Levin
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(3)
Plasma pharmacokinetics, biodistribution, excretion, and metabolism of four modified 20-mer antisense oligonucleotides targeted to human intercellular adhesion molecule-1 mRNA have been characterized in rats and compared with a first-generation phosp
Autor:
R Z, Yu, H, Zhang, R S, Geary, M, Graham, L, Masarjian, K, Lemonidis, R, Crooke, N M, Dean, A A, Levin
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(2)
ISIS 22023 is a modified phosphorothioate antisense oligonucleotide targeting murine Fas mRNA. Treatment of mice with ISIS 22023 reduced Fas expression in liver in a concentration-dependent and sequence-specific manner, which completely protected mic
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(5)
Raf proteins play a central role in the mitogen-activated protein kinase signaling pathway and hence are involved in oncogenic transformation and tumor cell proliferation. ISIS 5132 is a 20-base antisense phosphorothioate oligodeoxyribonucleotide tha
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(11)
Protein kinase C (PKC) is an attractive target in cancer therapy. It is overexpressed in a variety of cancers, and nonspecific inhibitors of PKC have demonstrated antitumor activity. Antisense oligonucleotides targeted against PKC-alpha, which have h