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Randomized phase 2 study of gemcitabine and cisplatin with or without vitamin supplementation in patients with advanced esophagogastric cancer

Autor: C. J. van Groeningen, Elisa Giovannetti, G.J. Peters, R. Ruijter, Henk M.W. Verheul, Giuseppe Giaccone, A. A. van Zweeden, Richard J. Honeywell, Carolien H. Smorenburg, Hans J. van der Vliet

Publikováno v: van Zweeden, A A, van Groeningen, C J, Honeywell, R J, Giovannetti, E, Ruijter, R, Smorenburg, C H, Giaccone, G, Verheul, H M W, Peters, G J & van der Vliet, H J 2018, ' Randomized phase 2 study of gemcitabine and cisplatin with or without vitamin supplementation in patients with advanced esophagogastric cancer ', Cancer Chemotherapy and Pharmacology, vol. 82, no. 1, pp. 39-48 . https://doi.org/10.1007/s00280-018-3588-6
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology, 82(1), 39-48. Springer Verlag

PURPOSE: Preclinical research and prior clinical observations demonstrated reduced toxicity and suggested enhanced efficacy of cisplatin due to folic acid and vitamin B12 suppletion. In this randomized phase 2 trial, we evaluated the addition of foli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2502b3d61670f51491c3457468559503
https://research.vumc.nl/en/publications/2bf1b93c-372d-48e0-ac96-fc8c6c2699d3

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Extension of a Fourier-Cosine Method to Solve BSDEs with Higher Dimensions

Autor: Cornelis W. Oosterlee, M. R. Ruijter, M. Pou

Publikováno v: Mathematics in Industry ISBN: 9783319234120

A Backward Stochastic Differential Equation (BSDE) is a stochastic differential equation for which a terminal condition has been specified. In Ruijter and Oosterlee (A Fourier-cosine method for an efficient computation of solutions to BSDEs, 2013) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0d59fb37fdf0dab562f027885c852f8
https://doi.org/10.1007/978-3-319-23413-7_12

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Phase I and pharmacokinetic study of the novel chemoprotector BNP7787 in combination with cisplatin and attempt to eliminate the hydration schedule

Autor: Epie Boven, I Zegers, C. J. van Groeningen, M Westerman, W.J.F. van der Vijgh, Miranda Verschraagen, G. Giaccone, R. Ruijter

Publikováno v: British Journal of Cancer

BNP7787 (disodium 2,2'-dithio-bis-ethane sulphonate; Tavocept) is a novel agent developed to protect against cisplatin (cis-diammine-dichloroplatinum(II))-associated chronic toxicities. In this study, we determined the recommended dose of BNP7787 whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6221dc37e4f8fac566d7499f04aa9b0d
https://doi.org/10.1038/sj.bjc.6602553

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Randomized phase 2 study of gemcitabine and cisplatin with or without vitamin supplementation in patients with advanced esophagogastric cancer (AEGC)

Autor: Richard J. Honeywell, R. Ruijter, Annette Van Zweeden, Godefridus J. Peters, Cees J. van Groeningen, Giuseppe Giaccone, Henk M.W. Verheul, Hans J. van der Vliet, Carolien H. Smorenburg

Publikováno v: Journal of Clinical Oncology. 34:e15555-e15555

e15555Background: The overall prognosis of patients with AECG is poor. Research suggests enhanced efficacy and reduced toxicity of cisplatin due to folic acid and vitamin B12 suppletion. In this ra...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d73f1794ac8a3aff7d2b64c5a090e48
https://doi.org/10.1200/jco.2016.34.15_suppl.e15555

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Spisulosine (ES-285) given as a weekly three-hour intravenous infusion: results of a phase I dose-escalating study in patients with advanced solid malignancies

Autor: Patrick Schöffski, Vicente Alfaro, Herlinde Dumez, G. Giaccone, Bernardo Miguel-Lillo, Arturo Soto-Matos, R. Ruijter

Publikováno v: Cancer Chemotherapy and Pharmacology, 68(6), 1397-1403. Springer Verlag
Schoffski, P, Dumez, H, Ruijter, R, Miguel-Lillo, B, Soto-Matos, A, Alfaro, V & Giaccone, G 2011, ' Spisulosine (ES-285) given as a weekly three-hour intravenous infusion: results of a phase I dose-escalating study in patients with advanced solid malignancies ', Cancer Chemotherapy and Pharmacology, vol. 68, no. 6, pp. 1397-1403 . https://doi.org/10.1007/s00280-011-1612-1

Spisulosine is a marine compound that showed antitumor activity in preclinical studies. We report results of a phase I trial performed in patients with advanced solid tumors with the marine compound, with the aim to determine the maximum tolerated do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e4cc7a67d9845e82a6538f6b324231
http://www.vliz.be/nl/open-marien-archief?module=ref&refid=257564

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A phase 1 study of weekly high dose sunitinib in patients with advanced solid tumors: Early signs of activity in non-RCC tumor types

Autor: Richard R. de Haas, Anne Marije Luik, Arjan W. Griffioen, Mariette Labots, Johannes Voortman, Dennis Poel, Richard J. Honeywell, R. Ruijter, Godefridus J. Peters, Maria Rovithi, Henk M.W. Verheul

Publikováno v: Journal of Clinical Oncology, 33(15). American Society of Clinical Oncology
Rovithi, M, Voortman, J, Luik, A M, Ruijter, R, de Haas, R, Honeywell, R, Labots, M, Poel, D, Peters, G J, Griffioen, A W & Verheul, H M W 2015, ' A phase 1 study of weekly high dose sunitinib in patients with advanced solid tumors: Early signs of activity in non-RCC tumor types ', Journal of Clinical Oncology, vol. 33, no. 15 .

e13550 Background: Increased exposure to sunitinib is associated with improved outcome. Preclinical data shows promising antitumor activity of intermittent exposure to high sunitinib concentrations...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20804932c95c792b249168e226317ffe
https://doi.org/10.1200/jco.2015.33.15_suppl.e13550

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