Zobrazeno 1 - 10
of 195
pro vyhledávání: '"R. Rollins"'
Autor:
Meagan R. Rollins, Jackson F. Raynor, Ebony A. Miller, Jonah Z. Butler, Ellen J. Spartz, Walker S. Lahr, Yun You, Adam L. Burrack, Branden S. Moriarity, Beau R. Webber, Ingunn M. Stromnes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
The currently available transgenic T cell receptor (TCR) models represent high affinity antigen-TCR interactions. Authors here present an alternative approach to target an exogenous TCR into the physiological Trac locus in the germline of mice, which
Externí odkaz:
https://doaj.org/article/f686ccd3ae77471d8e50f4e9b637e5d1
Autor:
Brandon J. Burbach, Stephen D. O’Flanagan, Qi Shao, Katharine M. Young, Joseph R. Slaughter, Meagan R. Rollins, Tami Jo L. Street, Victoria E. Granger, Lalit. K. Beura, Samira M. Azarin, Satish Ramadhyani, Bruce R. Forsyth, John C. Bischof, Yoji Shimizu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Irreversible electroporation (IRE), a soft-tissue ablation technique used for tumour ablation, has been suggested to promote systemic immune responses. Here the authors show that IRE, followed by anti-CTLA-4 blockade, elicits the expansion of tumor a
Externí odkaz:
https://doaj.org/article/ea3da0e70d734be09e22818a11a9695a
Autor:
Adam L. Burrack, Zoe C. Schmiechen, Michael T. Patterson, Ebony A. Miller, Ellen J. Spartz, Meagan R. Rollins, Jackson F. Raynor, Jason S. Mitchell, Tsuneyasu Kaisho, Brian T. Fife, Ingunn M. Stromnes
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
We investigate how myeloid subsets differentially shape immunity to pancreatic ductal adenocarcinoma (PDA). We show that tumor antigenicity sculpts myeloid cell composition and functionality. Antigenicity promotes accumulation of type 1 dendritic cel
Externí odkaz:
https://doaj.org/article/78e01ca8e9fd4f30a7edc6e8a733121d
Autor:
Philip D Greenberg, Patrick Bonson, Sunil R Hingorani, Ayaka Hulbert, Meagan R Rollins, Ryan S Basom, Jeffrey Delrow, Adam L Burrack
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)
Background Achieving robust responses with adoptive cell therapy for the treatment of the highly lethal pancreatic ductal adenocarcinoma (PDA) has been elusive. We previously showed that T cells engineered to express a mesothelin-specific T cell rece
Externí odkaz:
https://doaj.org/article/0ce5efbe9025488eb29b3b4f114e582e
Autor:
Adam L. Burrack, Ellen J. Spartz, Meagan R. Rollins, Ebony A. Miller, Maria Firulyova, Eduardo Cruz, Michael F. Goldberg, Iris X. Wang, Hezkiel Nanda, Steven Shen, Konstantin Zaitsev, Ingunn M. Stromnes
Publikováno v:
Cancer Immunology, Immunotherapy. 72:1461-1478
Pancreatic ductal adenocarcinoma (PDA) is a lethal and metastatic malignancy resistant to therapy. Elucidating how pancreatic tumor-specific T cells differentiate and are maintained in vivo could inform novel therapeutic avenues to promote T cell ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a800b3a2978443d4dca76a444b603707
https://doi.org/10.1007/s00262-022-03338-7
https://doi.org/10.1007/s00262-022-03338-7
Autor:
Satheesh Chonat, Sara Graciaa, H. Stella Shin, Joanna G. Newton, Maa-Ohui Quarmyne, Jeanne Boudreaux, Amy Tang, Patricia E. Zerra, Margo R. Rollins, Cassandra D. Josephson, Clark Brown, Clinton H. Joiner, Ross M. Fasano, Sean R. Stowell
Publikováno v:
Haematologica, Vol 105, Iss 12 (2020)
Externí odkaz:
https://doaj.org/article/b50b93eacca349d7808882d39967b343
Autor:
Christena A. Kolakowski, Donald R. Rollins, Theodore Jennermann, Allen D. Stevens, James T. Good, Joshua L. Denson, Richard J. Martin
Publikováno v:
Sleep Science and Practice, Vol 2, Iss 1, Pp 1-7 (2018)
Abstract Background Symptoms of acquired tracheobronchomalacia (TBM) include wheezing, shortness of breath, and chronic cough, and can negatively affect quality of life. Successful treatment of TBM requires identification of the disorder and of contr
Externí odkaz:
https://doaj.org/article/495a7eec08f54d2dade1ead3490b21ad
Publikováno v:
Developmental Biology. 491:82-93
In the early syncytial Drosophila embryo, rapid changes in filamentous actin networks and membrane trafficking pathways drive the formation and remodeling of cortical and furrow morphologies. Interestingly, genomic integrity and the completion of mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1e6a10866ae797c24063948a64a199
https://doi.org/10.1016/j.ydbio.2022.08.004
https://doi.org/10.1016/j.ydbio.2022.08.004
Publikováno v:
Journal of Immunology Research, Vol 2017 (2017)
Tumor cells are capable of limiting antitumor CD8+ T cell responses through their cell surface expression of PD-L1. In addition to PD-1 expressed by CD8+ T cells, PD-L1 also binds to CD80 expressed by CD8+ T cells. The influence of the PD-L1/CD80 int
Externí odkaz:
https://doaj.org/article/15bf37ccd45647e38cfb4663b01511a8
Publikováno v:
Gregory's Pediatric Anesthesia. :247-275
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e63ceff3c3e25c4c3b3b4381321739a1
https://doi.org/10.1002/9781119371533.ch12
https://doi.org/10.1002/9781119371533.ch12