Zobrazeno 1 - 10
of 126
pro vyhledávání: '"R. Roggeband"'
Autor:
R. Roggeband, Marco Corvaro, Hans Bender, D. A. Basketter, Jim Bridges, F. Lamplmair, Boris P. Müller, Silvia Casati, A. Irizar, Petra S. Kern, Laura H. Rossi, Sonja Beken, S. Cuvellier, Irene Manou, Miriam N. Jacobs, Bruno Hubesch
Publikováno v:
Regulatory Toxicology and Pharmacology. 117:104767
Skin sensitising substances that induce contact allergy and consequently risk elicitation of allergic contact dermatitis (ACD) remain an important focus regarding the replacement of animal experimentation. Current in vivo methods, notably the local l
Publikováno v:
Contact Dermatitis. 46:211-219
A new chemical called nonanoyl amido caproylacid oxybenzenesulphonate (NACAOBS) is being developed for use as a bleach activator in laundry detergents. Bleach activators, like NACAOBS, are typically used at levels between 2% and 6% in laundry deterge
Publikováno v:
Toxicology. 167:159-162
Publikováno v:
Contact Dermatitis. 44:321-324
The new Dangerous Preparations Directive (DPD, 1999/45/EC) introduces a special labelling requirement for skin sensitizers in products that are regulated under this Directive. The packaging of products containing 0.1% of a sensitizer must bear the in
Autor:
G. Stropp, R. Roggeband, Ian Kimber, M Butler, C. Newsome, S. Waterman, C. Wiemann, J.-L. Garrigue, L. Lea, K. Berthold, W. Steiling, D. A. Basketter
Publikováno v:
Toxicological Sciences. 59:198-208
The purpose of this article is to review, and make recommendations for, the use of relevant skin sensitization test methods, for the purposes of determination of relative potency and the threshold dose necessary for the induction of skin sensitizatio
Publikováno v:
Carcinogenesis. 14:463-467
Hamster tracheal organ cultures were used to investigate the relationship between DNA adduct formation measured directly by the 32P-postlabeling assay, and the DNA damage measured indirectly by the unscheduled DNA synthesis (UDS) assay. Hamster trach
Publikováno v:
Carcinogenesis. 14:1945-1950
An interspecies comparison was made of the DNA-adducts formed in vitro upon incubation of rat liver DNA (RL-DNA) with benzo[a]pyrene (BP) in the presence of liver microsomes. Incubations were carried out with RL-DNA, BP (100 microM) and liver microso
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 54(3)
Eye irritation is an important endpoint in the safety evaluation of consumer products and their ingredients. Several in vitro methods have been developed and are used by different industry sectors to assess eye irritation. One such in vitro method in
Publikováno v:
Humanexperimental toxicology. 22(8)
During the last 10 years there have been several attempts to define criteria for the integration of experimental and clinical data into schemes that can be used for the designation of chemicals as skin sensitizers (and in some instances respiratory a
Autor:
L. Lea, C. Newsome, Ian Kimber, M Butler, G. Stropp, C. Wiemann, J.-L. Garrigue, D. A. Basketter, S. Waterman, R. Roggeband, W. Steiling, K. Berthold
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 39(4)
Various methodological aspects of skin sensitisation testing have been explored, particularly in the context of animal welfare considerations and reliability and sensitivity of test methods. Recommendations are made for the conduct of current and pro