Zobrazeno 1 - 10
of 212
pro vyhledávání: '"R. Roffler"'
Autor:
Huei-Jen Chen, Yi-An Cheng, Yu-Tung Chen, Chia-Ching Li, Bo-Cheng Huang, Shih-Ting Hong, I.-Ju Chen, Kai-Wen Ho, Chiao-Yun Chen, Fang-Ming Chen, Jaw-Yuan Wang, Steve R. Roffler, Tian-Lu Cheng, Tung-Ho Wu
Publikováno v:
Cancer Nanotechnology, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background PEGylated nanoparticles (PEG-NPs) are not effective for hematologic malignancies as they lack the enhanced permeability and retention effect (EPR effect). Tumor-targeted PEG-NPs can systemically track lymphoma and actively interna
Externí odkaz:
https://doaj.org/article/d7e948b59260455786e1f5ea63ad1238
Autor:
Minh-Tram T. Nguyen, Yu-Chien Shih, Meng-Hsuan Lin, Steve R. Roffler, Chiao-Yu Hsiao, Tian-Lu Cheng, Wen-Wei Lin, En-Chi Lin, Yuh-Jyh Jong, Chin-Yuan Chang, Yu-Cheng Su
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-8 (2022)
Methoxy polyethylene glycol (mPEG) is widely attached to drug molecules to improve their therapeutic efficacy, however mPEG can induce anti-PEG antibodies that negatively impact their therapeutic effects. Here, the authors determine the co-crystal st
Externí odkaz:
https://doaj.org/article/3bd2b80b635d43d5a3b29f476d587e7e
The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Al-Aghbar et al propose a TCR bending mechanosignal model that demonstrates how local mechanical membrane bending may influence T cell receptor binding events and thus T-cell activation.
Externí odkaz:
https://doaj.org/article/2cf323d87f154e119a99068dfe573300
Autor:
Binay K. Sahoo, Yuh-Charn Lin, Cheng-Fen Tu, Chien-Chin Lin, Wei-Ju Liao, Fu-An Li, Ling-Hui Li, Kurt Yun Mou, Steve R. Roffler, Shu-Ping Wang, Chi-Tai Yeh, Chi-Yuan Yao, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien, Ruey-Bing Yang
Publikováno v:
Haematologica, Vol 108, Iss 5 (2022)
A hallmark of mixed lineage leukemia gene-rearranged (MLL-r) acute myeloid leukemia that offers an opportunity for targeted therapy is addiction to protein tyrosine kinase signaling. One such signal is the receptor tyrosine kinase Fms-like receptor t
Externí odkaz:
https://doaj.org/article/d8f955e1c015423ea6018dcfad0ba05e
Autor:
Hsien-Ya Lin, Chia-Yu Chen, Ting-Chien Lin, Lun-Fu Yeh, Wei-Che Hsieh, Shijay Gao, Pierre-Alain Burnouf, Bing-Mae Chen, Tung-Ju Hsieh, Punsaldulam Dashnyam, Yen-Hsi Kuo, Zhijay Tu, Steve R. Roffler, Chun-Hung Lin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Hsien-Ya Lin, Chia-Yu Chen, Ting-Chien Lin and colleagues perform structure-guided modifications of the compound uronic isofagomaine in order to engineer a highly specific and potent inhibitor of gut bacterial β-glucuronidases (GUSs). The authors pr
Externí odkaz:
https://doaj.org/article/fb39bb5584a546bea3aca76fb3fd4c02
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 148-154 (2021)
Polyethylene glycol (PEG) is a biocompatible polymer used in biotherapeutics to increase bioavailability, reduce the frequency of administration, and optimize pharmacokinetics. Anti-PEG antibodies have been detected in healthy individuals and may dec
Externí odkaz:
https://doaj.org/article/28bf6583faa44ed4b1fc8da7ae99fd07
Autor:
Kai-Wen Ho, I.-J.u Chen, Yi-An Cheng, Tzu-Yi Liao, En-Shuo Liu, Huei-Jen Chen, Yun-Chi Lu, Yu-Cheng Su, Steve R. Roffler, Bo-Cheng Huang, Hui-Ju Liu, Ming-Yii Huang, Chiao-Yun Chen, Tian-Lu Cheng
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background Tumor-targeted nanoparticles hold great promise as new tools for therapy of liquid cancers. Furthermore, the therapeutic efficacy of nanoparticles can be improved by enhancing the cancer cellular internalization. Methods In this s
Externí odkaz:
https://doaj.org/article/90203a981820425d90aa6193a4e80d5c
Autor:
Kai-Wen Cheng, Chih-Hua Tseng, I.-Ju Chen, Bo-Cheng Huang, Hui-Ju Liu, Kai-Wen Ho, Wen-Wei Lin, Chih-Hung Chuang, Ming-Yii Huang, Yu-Lin Leu, Steve R. Roffler, Jaw-Yuan Wang, Yeh-Long Chen, Tian-Lu Cheng
Publikováno v:
Pharmacological Research, Vol 177, Iss , Pp 106115- (2022)
The bidirectional interaction between carcinogens and gut microbiota that contributes to colorectal cancer is complicated. Reactivation of carcinogen metabolites by microbial β-glucuronidase (βG) in the gut potentially plays an important role in co
Externí odkaz:
https://doaj.org/article/55f73cca8fc546a79e2f4bf887feeae5
Autor:
Cheng-Chung Lee, Yu-Cheng Su, Tzu-Ping Ko, Li-Ling Lin, Chih-Ya Yang, Stanley Shi-Chung Chang, Steve R. Roffler, Andrew H.-J. Wang
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-13 (2020)
Abstract Background Polyethylene glycol (PEG) is widely used in industry and medicine. Anti-PEG antibodies have been developed for characterizing PEGylated drugs and other applications. However, the underlying mechanism for specific PEG binding has n
Externí odkaz:
https://doaj.org/article/51050d5c634946ccafb198fd1f73c742
Autor:
Hung-Jun Lin, Tien-Li Liang, Yao-Yuan Chang, Der-Zen Liu, Jia-Yu Fan, Steve R. Roffler, Shyr-Yi Lin
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1202 (2022)
Pancreatic cancer is one of the most common causes of death in Taiwan. Previous studies have shown that more than 90% of pancreatic cancer cells presented epidermal growth factor receptor (EGFR) cell marker, and this marker is thought to be important
Externí odkaz:
https://doaj.org/article/2b060543768046e083e039cbdfa73814