Zobrazeno 1 - 10
of 26
pro vyhledávání: '"R. Richard Pencek"'
Autor:
David E. Kelley, R. Richard Pencek, Alessandra Bertoldo, Carol Kelley, Koichiro Azuma, Julie C. Price, Claudio Cobelli, Jason M. Ng, Bret H. Goodpaster
Publikováno v:
Diabetes
Dynamic positron emission tomography (PET) imaging was performed using sequential tracer injections ([15O]H2O, [11C]3-O-methylglucose [3-OMG], and [18F]fluorodeoxyglucose [FDG]) to quantify, respectively, skeletal muscle tissue perfusion (glucose del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc23099830985cb2fb2535242ae12cb
http://europepmc.org/articles/PMC3931396
http://europepmc.org/articles/PMC3931396
Autor:
David E. Kelley, Charles M. Laymon, Bret H. Goodpaster, Julie C. Price, Jason M. Ng, R. Richard Pencek, Carol Kelley, Koichiro Azuma, Zofia Radikova
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 303:E1134-E1141
Excess amounts of abdominal subcutaneous (SAT) and visceral (VAT) adipose tissue (AT) are associated with insulin resistance, even in normal-weight subjects. In contrast, gluteal-femoral AT (GFAT) is hypothesized to offer protection against insulin r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990cc01238988b6ddb77bfc78f4b9404
https://doi.org/10.1152/ajpendo.00282.2012
https://doi.org/10.1152/ajpendo.00282.2012
Autor:
Kimberly R. Coenen, R. Richard Pencek, Larry L. Swift, Jane Shearer, Jeffrey N. Rottman, David H. Wasserman
Publikováno v:
Lipids. 43:703-711
Insulin resistance is characterized by increased metabolic uptake of fatty acids. Accordingly, techniques to examine in vivo shifts in fatty acid metabolism are of value in both clinical and experimental settings. Partially metabolizable long chain f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8961a9691602a45d6cbb1a3b8d06516
https://doi.org/10.1007/s11745-008-3183-4
https://doi.org/10.1007/s11745-008-3183-4
Autor:
Koichiro Azuma, Alessandra Bertoldo, Carol Kelley, David E. Kelley, R. Richard Pencek, Julie C. Price, Claudio Cobelli
Publikováno v:
Diabetes. 55:3028-3037
Skeletal muscle accounts for a large proportion of insulin-stimulated glucose utilization. It is generally regarded that much of the control over rates of uptake is posited within the proximal steps of delivery, transport, and phosphorylation of gluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648a2aa264ae8a0ddd6cda2045911490
https://doi.org/10.2337/db06-0762
https://doi.org/10.2337/db06-0762
Publikováno v:
Canadian Journal of Applied Physiology. 30:292-303
The liver is anatomically well situated to regulate blood glucose. It is positioned downstream from the pancreas, which releases the key regulatory hormones glucagon and insulin. It is also just downstream from the gut, permitting efficient extractio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92d2bea4b665f74392d6c23e2fbafad
https://doi.org/10.1139/h05-122
https://doi.org/10.1139/h05-122
Autor:
Raul C. Camacho, David H. Wasserman, Freyja D. James, R. Richard Pencek, D. Brooks Lacy, E. Patrick Donahue
Publikováno v:
Diabetes. 54:373-382
AMP-activated protein kinase (AMPK) plays a key role in regulating metabolism, serving as a metabolic master switch. The aim of this study was to assess whether increased concentrations of the AMP analog, 5-aminoimidazole-4-carboxamide-1-beta-D-ribos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae9dde1fae63fd5e07810f1dc57a917
https://doi.org/10.2337/diabetes.54.2.373
https://doi.org/10.2337/diabetes.54.2.373
Autor:
R. Richard Pencek, Jane Shearer, Owen P. McGuinness, Kelly A. Posey, David H. Wasserman, Patrick T. Fueger, Deanna P. Bracy
Publikováno v:
The Journal of Physiology. 562:925-935
The aim of this study was to test whether in fact glucose transport is rate-limiting in control of muscle glucose uptake (MGU) under physiological hyperinsulinaemic conditions in the conscious, unrestrained mouse. C57Bl/6J mice overexpressing GLUT4 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1908a7d521e5d1da6499889f10434b05
https://doi.org/10.1113/jphysiol.2004.076158
https://doi.org/10.1113/jphysiol.2004.076158
Autor:
Patrick T. Fueger, D. Brooks Lacy, R. Richard Pencek, Freyja D. James, Phillip E. Williams, Kareem Jabbour, David H. Wasserman
Publikováno v:
Diabetes. 53:3041-3047
To test whether pancreatic hormonal changes that occur during exercise are necessary for the postexercise enhancement of insulin-stimulated net hepatic glucose uptake, chronically catheterized dogs were exercised on a treadmill or rested for 150 min.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc2b4f03859a3cc58628df327428964
https://doi.org/10.2337/diabetes.53.12.3041
https://doi.org/10.2337/diabetes.53.12.3041
Autor:
Daryl K. Granner, R. Richard Pencek, Carlo M. Malabanan, Patrick T. Fueger, David H. Wasserman, Deanna P. Bracy
Publikováno v:
Diabetes. 53:306-314
The aim of the present study was to determine the specific sites of impairment to muscle glucose uptake (MGU) in the insulin-resistant high-fat-fed, conscious C57BL/6J mouse. Wild type (WT) and hexokinase II overexpressing (HK(Tg)) mice were fed eith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e77fba0ca5428c1a4b0b830f7b21395
https://doi.org/10.2337/diabetes.53.2.306
https://doi.org/10.2337/diabetes.53.2.306
Publikováno v:
Diabetes. 53:285-293
Hyperinsulinemia during exercise in people with diabetes requiring exogenous insulin is a major clinical problem. The aim of this study was to assess the significance of portal vein versus arterial insulin to hepatic effects of hyperinsulinemia durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7629461e1a527601049e827245340c
https://doi.org/10.2337/diabetes.53.2.285
https://doi.org/10.2337/diabetes.53.2.285