Zobrazeno 1 - 10
of 11
pro vyhledávání: '"R. Richard L. Hamer"'
Autor:
Elizabeth J. Salm, Patrick J. Dunn, Lili Shan, Miwako Yamasaki, Nathalie M. Malewicz, Taisuke Miyazaki, Joongkyu Park, Akio Sumioka, R. Richard L. Hamer, Wei-Wu He, Megumi Morimoto-Tomita, Robert H. LaMotte, Susumu Tomita
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: Fast purinergic signaling is mediated by ATP and ATP-gated ionotropic P2X receptors (P2XRs), and it is implicated in pain-related behaviors. The properties exhibited by P2XRs vary between those expressed in heterologous cells and in vivo. Se
Externí odkaz:
https://doaj.org/article/989eda6db00a41328abe0881dd92de9a
Autor:
Akio Sumioka, Wei-Wu He, Susumu Tomita, Patrick Dunn, Joongkyu Park, Nathalie M. Malewicz, Lili Shan, R. Richard L. Hamer, Elizabeth J. Salm, Miwako Yamasaki, Taisuke Miyazaki, Megumi Morimoto-Tomita, Robert H. LaMotte
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp-(2020)
Cell Rep
Cell Rep
Summary Fast purinergic signaling is mediated by ATP and ATP-gated ionotropic P2X receptors (P2XRs), and it is implicated in pain-related behaviors. The properties exhibited by P2XRs vary between those expressed in heterologous cells and in vivo. Sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7392894e8bd47918013c50e25d7a66e
http://www.sciencedirect.com/science/article/pii/S2211124720306744
http://www.sciencedirect.com/science/article/pii/S2211124720306744
Autor:
R. Richard L. Hamer, Lawrence L. Martin, John J. Tegeler, Ellen S. Kurtz, Penelope A. Przekop, Mary Ellen Elliott, Luther Hellyer, Steven C. Bailey, Richard C. Allen, Helsley Grover C, John H. White, Brian S. Freed
Publikováno v:
Journal of Medicinal Chemistry. 39:246-252
Hydroxylamine and hydroxamic acid derivatives of a known nonsteroidal antiinflammatory dibenzoxepine series display both cyclooxygenase (CO) and 5-lipoxygenase (5-LO) inhibitory properties. Many of these new dual CO/5-LO inhibitors also exhibit poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3471acc01b0cd7d342a64e3625c94b84
https://doi.org/10.1021/jm950563z
https://doi.org/10.1021/jm950563z
Autor:
Rauckman Barbara S, Brian S. Freed, John J. Tegeler, Gregory H. Merriman, Marie Ortega-Nanos, R. Richard L. Hamer, Luther Hellyer, Ellen S. Kurtz, Steven C. Bailey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2477-2482
Novel aryl-fused sphingolipids, in which aryl-/heteroaryl-moieties were incorporated into the allylic 4,5,6-positions of sphingosine, were prepared and found to possess good in vitro PKC inhibitory activity. (3-(1-Dodecynyl)phenyl)- and (4- and (5-(1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceadbec253667ba3e4cc7eca6f7fb763
https://doi.org/10.1016/0960-894x(95)00427-u
https://doi.org/10.1016/0960-894x(95)00427-u
Autor:
R. Richard L. Hamer, Luther Hellyer, John J. Tegeler, Marie Ortega-Nanos, Penelope A. Przekop, Rauckman Barbara S, Brian S. Freed, Steven C. Bailey, Gregory H. Merriman, Ellen S. Kurtz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2483-2488
Recently we identified three promising topically active antiinflammatory agents ( 2 , 3 , and 4 ) from a series of racemic aryl-sphingolipids that inhibit protein kinase C (PKC). We now wish to report the enantioselective synthesis of the aforementio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::361f411e5c07a3ef8d3394c4d5d432bc
https://doi.org/10.1016/0960-894x(95)00428-v
https://doi.org/10.1016/0960-894x(95)00428-v
Autor:
Penelope A. Przekop, Gregory H. Merriman, Steven C. Bailey, Luther Hellyer, Brian S. Freed, Marie Ortega-Nanos, R. Richard L. Hamer, John J. Tegeler, Ellen S. Kurtz, Rauckman Barbara S
Publikováno v:
ChemInform. 27
Recently we identified three promising topically active antiinflammatory agents ( 2 , 3 , and 4 ) from a series of racemic aryl-sphingolipids that inhibit protein kinase C (PKC). We now wish to report the enantioselective synthesis of the aforementio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bd028e045e24bec382fbbbe3d9f104f
https://doi.org/10.1002/chin.199609278
https://doi.org/10.1002/chin.199609278
Autor:
Steven C. Bailey, Luther Hellyer, Penelope A. Przekop, Lawrence L. Martin, John H. White, Mary Ellen Elliott, Brian S. Freed, Helsley Grover C, R. Richard L. Hamer, Ellen S. Kurtz, Richard C. Allen, John J. Tegeler
Publikováno v:
ChemInform. 27
Hydroxylamine and hydroxamic acid derivatives of a known nonsteroidal antiinflammatory dibenzoxepine series display both cyclooxygenase (CO) and 5-lipoxygenase (5-LO) inhibitory properties. Many of these new dual CO/5-LO inhibitors also exhibit poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39df8bb023c63c090f846186f9796a38
https://doi.org/10.1002/chin.199618158
https://doi.org/10.1002/chin.199618158
Publikováno v:
Journal of Heterocyclic Chemistry. 25:991-994
The synthesis of the pyrrolo[1,2-b]cinnoline analogs 2 and 4–13 is described. The key step of this synthesis involves an intramolecular aromatic halide displacement on [2-(2-halobenzoyl)pyrrol-1-yl]carbamic acid esters. Several reactions of these c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1737f62df024329a705deaa2de54f8af
https://doi.org/10.1002/jhet.5570250355
https://doi.org/10.1002/jhet.5570250355
Publikováno v:
Journal of Heterocyclic Chemistry. 25:517-521
The synthesis of a series of 5-phenylpyrrolo[1,2-b][1,2,5]triazepin-2(3H)-ones 1 as potential anxiolytic agents is described. Benzoylation of 1-phthalimidopyrrole, followed by hydrolysis, gave the 1-amino-2-benzoylpyrroles 3. These were further funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c41afd40a4d001a5f9ec6c3ea8b659a7
https://doi.org/10.1002/jhet.5570250230
https://doi.org/10.1002/jhet.5570250230
Publikováno v:
ChemInform. 20
The synthesis of the pyrrolo[1,2-b]cinnoline analogs 2 and 4–13 is described. The key step of this synthesis involves an intramolecular aromatic halide displacement on [2-(2-halobenzoyl)pyrrol-1-yl]carbamic acid esters. Several reactions of these c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e75c9da4cb91ee1e35edcf398910cec3
https://doi.org/10.1002/chin.198914233
https://doi.org/10.1002/chin.198914233