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Reciprocal integrin/integrin antagonism through kindlin-2 and Rho GTPases regulates cell cohesion and collective migration

Autor: Nathalie R. Reinhard, Ana Jimenez Orgaz, Ugne Kazlauskaite, Simon Tol, Ivo van der Bijl, Anne-Marieke D. van Stalborch, Iman van den Bout, Arnoud Sonnenberg, Kalim Nawaz, Coert Margadant

Publikováno v: Matrix biology, 93, 60-78. Elsevier

Collective cell behaviour during embryogenesis and tissue repair requires the coordination of intercellular junctions, cytoskeleton-dependent shape changes controlled by Rho GTPases, and integrin-dependent cell-matrix adhesion. Many different integri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878c37e4eaa11c8dd21de79cde1fcaf0
https://doi.org/10.1016/j.matbio.2020.05.005

Superior skin cancer classification by the combination of human and artificial intelligence

Autor: Achim Hekler, Jochen S. Utikal, Alexander H. Enk, Axel Hauschild, Michael Weichenthal, Roman C. Maron, Carola Berking, Sebastian Haferkamp, Joachim Klode, Dirk Schadendorf, Bastian Schilling, Tim Holland-Letz, Benjamin Izar, Christof von Kalle, Stefan Fröhling, Titus J. Brinker, Laurenz Schmitt, Wiebke K. Peitsch, Friederike Hoffmann, Jürgen C. Becker, Christina Drusio, Philipp Jansen, Georg Lodde, Stefanie Sammet, Wiebke Sondermann, Selma Ugurel, Jeannine Zader, Alexander Enk, Martin Salzmann, Sarah Schäfer, Knut Schäkel, Julia Winkler, Priscilla Wölbing, Hiba Asper, Ann-Sophie Bohne, Victoria Brown, Bianca Burba, Sophia Deffaa, Cecilia Dietrich, Matthias Dietrich, Katharina Antonia Drerup, Friederike Egberts, Anna-Sophie Erkens, Salim Greven, Viola Harde, Marion Jost, Merit Kaeding, Katharina Kosova, Stephan Lischner, Maria Maagk, Anna Laetitia Messinger, Malte Metzner, Rogina Motamedi, Ann-Christine Rosenthal, Ulrich Seidl, Jana Stemmermann, Kaspar Torz, Juliana Giraldo Velez, Jennifer Haiduk, Mareike Alter, Claudia Bär, Paul Bergenthal, Anne Gerlach, Christian Holtorf, Ante Karoglan, Sophie Kindermann, Luise Kraas, Moritz Felcht, Maria R. Gaiser, Claus-Detlev Klemke, Hjalmar Kurzen, Thomas Leibing, Verena Müller, Raphael R. Reinhard, Jochen Utikal, Franziska Winter, Laurie Eicher, Daniela Hartmann, Markus Heppt, Katharina Kilian, Sebastian Krammer, Diana Lill, Anne-Charlotte Niesert, Eva Oppel, Elke Sattler, Sonja Senner, Jens Wallmichrath, Hans Wolff, Anja Gesierich, Tina Giner, Valerie Glutsch, Andreas Kerstan, Dagmar Presser, Philipp Schrüfer, Patrick Schummer, Ina Stolze, Judith Weber, Konstantin Drexler, Marion Mickler, Camila Toledo Stauner, Alexander Thiem

Publikováno v: European Journal of Cancer. 120:114-121

Background In recent studies, convolutional neural networks (CNNs) outperformed dermatologists in distinguishing dermoscopic images of melanoma and nevi. In these studies, dermatologists and artificial intelligence were considered as opponents. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2771b733ad75a6efdb2981c78683d43
https://doi.org/10.1016/j.ejca.2019.07.019

Outcome of melanoma patients with elevated LDH treated with first-line targeted therapy or PD-1-based immune checkpoint inhibition

Autor: Dirk Schadendorf, Carmen Loquai, Felix Kiecker, Konstantin Drexler, Laura Susok, Peter Mohr, Katharina C. Kähler, Leonie Bluhm, Lydia Reinhardt, Friedegund Meier, Jessica C. Hassel, Selma Ugurel, Claudia Pföhler, Sarah Knispel, Bastian Schilling, Christopher G. Cann, Simone M. Goldinger, Elisabeth Livingstone, Andreas Stang, Thomas Eigentler, Cindy Franklin, Julia K. Tietze, Maria Isabel Fleischer, Carola Berking, Paolo A. Ascierto, Judith Sirokay, Carsten Weishaupt, Patrick Schummer, Lisa Zimmer, Georgina V. Long, Maximilian Gassenmaier, Carina N. Owen, Lucie Heinzerling, Raphael R. Reinhard, Douglas B. Johnson, Kai Martin Thoms, Alexander M. Menzies, Dennis Niebel, Ralf Gutzmer

Publikováno v: European journal of cancer (Oxford, England : 1990). 148

Background Elevated lactate dehydrogenase (LDH) is a known predictive and prognostic factor for a poor outcome in patients with metastatic melanoma. It is unclear whether first-line targeted therapy (TT) or immune checkpoint inhibition (ICI) is more

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7b5b295efc1524ab0bf2996f38c02f
https://pubmed.ncbi.nlm.nih.gov/33735811

The balance between Gαi-Cdc42/Rac and Gα12/13-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate

Autor: Peter L. Hordijk, Theodorus W. J. Gadella, Esmeralda K. Bosma, Nathalie R. Reinhard, Joachim Goedhart, Yi I. Wu, Marieke Mastop, Taofei Yin

Publikováno v: Molecular biology of the cell, 28(23), 3371-3382. American Society for Cell Biology
Molecular Biology of the Cell, 28(23), 3371-3382. American Society for Cell Biology
Reinhard, N R, Mastop, M, Yin, T, Wu, Y, Bosma, E K, Gadella, T W J, Goedhart, J & Hordijk, P L 2017, ' The balance between Gα i-Cdc42/Rac and Gα 1/ 2/ 13-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate ', Molecular Biology of the Cell, vol. 28, no. 23, pp. 3371-3382 . https://doi.org/10.1091/mbc.E17-03-0136

The bioactive sphingosine-1-phosphatephosphate (S1P) is present in plasma, bound to carrier proteins, and involved in many physiological processes, including angiogenesis, inflammatory responses, and vascular stabilization. S1P can bind to several G-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe2ae73b96e3b0c6d308cba4eec2b7b
https://doi.org/10.1091/mbc.e17-03-0136