Donepezil inhibits neuromuscular junctional acetylcholinesterase and enhances synaptic transmission and function in isolated skeletal muscle

Autor: Robert R. Redman, Harry Mackenzie, Kosala N. Dissanayake, Michael Eddleston, Richard R. Ribchester

Publikováno v: Redman, R R, Mackenzie, H, Dissanayake, K, Eddleston, M & Ribchester, R 2022, ' Donepezil inhibits neuromuscular junctional acetylcholinesterase and enhances synaptic transmission and function in isolated skeletal muscle ', British Journal of Pharmacology . https://doi.org/10.1111/bph.15940

Background and PurposeDonepezil, a piperidine antagonist of acetylcholinesterase (AChE) prescribed for treatment of Alzheimer’s Disease, has adverse neuromuscular effects in humans, including requirement for higher concentrations of non-depolarisin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3998153fbd266bd15fafd8b7c94c348
https://doi.org/10.1111/bph.15940

‘Calcium bombs' as harbingers of synaptic pathology and their mitigation by magnesium at murine neuromuscular junctions

Autor: Kosala N, Dissanayake, Robert R, Redman, Harry, Mackenzie, Michael, Eddleston, Richard R, Ribchester

Publikováno v: Dissanayake, K, Redman, R R, Mackenzie, H, Eddleston, M & Ribchester, R 2022, ' ‘Calcium bombs' as harbingers of synaptic pathology and their mitigation by magnesium at murine neuromuscular junctions ', Frontiers in Molecular Neuroscience, vol. 15, 937974 . https://doi.org/10.3389/fnmol.2022.937974

Excitotoxicity is thought to be an important factor in the onset and progression of amyotrophic lateral sclerosis (ALS). Evidence from human and animal studies also indicates that early signs of ALS include degeneration of motor nerve terminals at ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9fe418b15fbbd4fb3441c14a1cd7fca
https://www.pure.ed.ac.uk/ws/files/290283094/fnmol_15_937974.pdf

Correction: SNP Discovery and Chromosome Anchoring Provide the First Physically-Anchored Hexaploid Oat Map and Reveal Synteny with Model Species.

Autor: Rebekah E. Oliver, Nicholas A. Tinker, Gerard R. Lazo, Shiaoman Chao, Eric N. Jellen, Martin L. Carson, Howard W. Rines, Donald E. Obert, Joseph D. Lutz, Irene Shackelford, Abraham B. Korol, Charlene P. Wight, Kyle M. Gardner, Jiro Hattori, Aaron D. Beattie, Åsmund Bjørnstad, J. Michael Bonman, Jean-Luc Jannink, Mark E. Sorrells, Gina L. Brown-Guedira, Jennifer W. Mitchell Fetch, Stephen A. Harrison, Catherine J. Howarth, Amir Ibrahim, Frederic L. Kolb, Michael S. McMullen, J. Paul Murphy, Herbert W. Ohm, Brian G. Rossnagel, Weikai Yan, Kelci J. Miclaus, Jordan Hiller, Peter J. Maughan, Rachel R. Redman Hulse, Joseph M. Anderson, Emir Islamovic, Eric W. Jackson

Publikováno v: PLoS ONE, Vol 8, Iss 10 (2013)

Externí odkaz: https://doaj.org/article/e219979cdc554607877e67c1a6efa5f0

Abstract P5-07-01: Computational scoring of tumor infiltrating lymphocytes in triple-negative breast cancer

Autor: Michael Barnes, CJ Bechert, Mohamed Amgad, S Ratra, Uday Kurkure, Anindya Sarkar, R Redman, Benjamin C. Calhoun, Karen C. Mrazeck, Chukka Srinivas, Lee Cooper

Publikováno v: Cancer Research. 79:P5-07

Background: Stromal Tumor Infiltrating Lymphocytes (sTIL) are an established prognostic feature in triple-negative breast cancer, yet manual assessment or visual estimation of sTILs with conventional light microscopy may be subject to inter-pathologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b970b51195a4442af47f38aaac828298
https://doi.org/10.1158/1538-7445.sabcs18-p5-07-01

Timing of sleep and its relationship with the endogenous melatonin rhythm

Autor: Tracey L Sletten, Simon Vincenzi, Jennifer R Redman, Steven W Lockley, Shantha M Rajaratnam

Publikováno v: Frontiers in Neurology, Vol 1 (2010)

While much research has investigated the effects of exogenous melatonin on sleep, less is known about the relationship between the timing of the endogenous melatonin rhythm and the sleep-wake cycle. Significant inter-individual variability in the pha

Externí odkaz: https://doaj.org/article/90fec880570a4aaf924932ddfcd9554a