Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Autor: Tove Fall, Anubha Mahajan, Dmitry Shungin, B. Balkau, Gerjan Navis, A. Metspalu, Anneli Pouta, Andrew A. Hicks, Ilja M. Nolte, Ian Ford, Aroon D. Hingorani, Stefan R Bornstein, Anuj Goel, Rona J. Strawbridge, Niek Verweij, Sarah H. Wild, Patricia B. Munroe, T.B. Harris, Jaana Lindström, Johnson Pcd., Nita G. Forouhi, Pierre Meneton, Patricia A. Peyser, Sarin A-P., Andrea Ganna, Timothy M. Frayling, Patrik K. E. Magnusson, Joanne M. Meyer, Yongmei Liu, Jeanette M. Stafford, Christian Herder, L Zudina, Maria G. Stathopoulou, May E. Montasser, Nicholas D. Hastie, Inês Barroso, Schwarz Peh., James B. Meigs, Perttu Salo, George Davey Smith, Gonneke Willemsen, Christopher J. Groves, Erik P A Van Iperen, M. A. Province, Veikko Salomaa, Naveed Sattar, Serena Sanna, Maria Dimitriou, Joop Jukema, Ulrika Krus, Albert V. Smith, Markku Laakso, James F. Wilson, George Nicholson, Loic Yengo, Tatijana Zemunik, Per Eriksson, Harold Snieder, Peter P. Pramstaller, Claudia Langenberg, R. Rauramaa, Alan R. Shuldiner, Pau Navarro, Veronique Vitart, Ross M. Fraser, Aaron Isaacs, C. Lecoeur, Jesper R. Gådin, Jackie F. Price, Letizia Marullo, L.F. Bielak, Sirkka Keinänen-Kiukaanniemi, Amélie Bonnefond, Michael Stumvoll, Alessia Faggian, Anke Tönjes, Tomohiro Tanaka, Wieland Kiess, Harry Campbell, Josée Dupuis, David Altshuler, João Fadista, Winfried März, G K Hovingh, Thomas Illig, Toby Johnson, H Grallert, Kari Stefansson, Reedik Mägi, Palmer Cna., de Geus Ejcn., Martina Müller-Nurasyid, Karen Kapur, Philippe Froguel, Dorret I. Boomsma, Anders Franco-Cereceda, Marcus E. Kleber, Boehnke M, Olga D. Carlson, Ozren Polasek, Andrew P. Morris, Alex S. F. Doney, Najaf Amin, Sara M. Willems, Vilmundur Gudnason, Jose C. Florez, Jeffery R. O'Connell, Nancy L. Pedersen, T. Saaristo, Wolffenbuttel Bhr., M. I. J. Uusitupa, Longda Jiang, Iva Miljkovic, James S. Pankow, Caroline Hayward, Hugh Watkins, Vasiliki Lagou, Johanna Kuusisto, Jaakko Tuomilehto, Alan F. Wright, Josephine M. Egan, Perry Jrb., C M van Duijn, Valeriya Lyssenko, Leif Groop, Stefania Bandinelli, Nigel W. Rayner, Tõnu Esko, Stela McLachlan, Momoko Horikoshi, Eric Boerwinkle, Rick Jansen, Richard N. Bergman, Gudmar Thorleifsson, Lyle J. Palmer, Vilmantas Giedraitis, Peter Kovacs, Nicholas J. Wareham, Luigi Ferrucci, N J Timpson, D Rybin, Anne U. Jackson, Tiinamaija Tuomi, Gonçalo R. Abecasis, Harst Pvd., Meena Kumari, Albert Hofman, Chiara Scapoli, Evelin Mihailov, Josine L. Min, Anders Hamsten, Hottenga J-J., Loos Rjf., Lars Lind, Ulf de Faire, Jaakko Kaprio, Guo Li, Beate St Pourcain, C Gieger, Amanda J. Bennett, Anna Ulrich, Nabila Bouatia-Naji, Satu Männistö, Antigone S. Dimas, Jarvelin M-R., Günther Silbernagel, F Karpe, A. Körner, David S. Siscovick, M Blüher, Rebecca J. Webster, Erik Ingelsson, Susan Campbell, Mika Kivimäki, Laura J. Rasmussen-Torvik, Heikki A. Koistinen, Sophie Visvikis-Siest, Bernhard O. Boehm, Inga Prokopenko, Ping An, Emmanouil T. Dermitzakis, Cecilia M. Lindgren, Kardia Slr., Richa Saxena, Igor Rudan, Richard M. Watanabe, Jian'an Luan, Marika Kaakinen, Shin S-Y., George Dedoussis, Panagiotis Deloukas, Mark I. McCarthy, Barbara Thorand, B.W.J.H. Penninx, Peter Vollenweider, Paul W. Franks, Leena Kinnunen, Markus Perola, Yvonne Boettcher, Timo A. Lakka, Nicole Soranzo, Stavroula Kanoni, Bakker Sjl., Winkelmann Br

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature Communications, 12(1):24, 1-18. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 12(1):24. Nature Publishing Group UK
Lagou, V, Mägi, R, Hottenga, J J, Jansen, R, Min, J L, Willemsen, G, De Geus, E J C N, Penninx, B W, Boomsma, D I, Barroso, I, Morris, A P, Prokopenko, I & MAGIC Collaboration 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24, pp. 1-18 . https://doi.org/10.1038/s41467-020-19366-9
Min, J L, St Pourcain, M U B, Timpson, N J, Davey Smith, G, Prokopenko, I & et al. 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, 24 . https://doi.org/10.1038/s41467-020-19366-9
2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-021-21276-3
Nature communications, vol. 12, no. 1, pp. 24
Nature Communications, 12(1). NATURE RESEARCH

Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5783e9d2579548e3deb52d1bbdf19db
https://hal.univ-lorraine.fr/hal-03105716

Health-related quality of life in a multidomain intervention trial to prevent cognitive decline (FINGER)

Autor: T.E. Strandberg, E. Levälahti, T. Ngandu, A. Solomon, M. Kivipelto, J. Lehtisalo, T. Laatikainen, H. Soininen, T. Strandberg, R. Antikainen, A. Jula, J. Tuomilehto, M. Peltonen, J. Lindström, R. Rauramaa, S. Pajala, T. Hänninen, T. Paajanen, F. Mangialasche

Publikováno v: European Geriatric Medicine. 8:164-167

Introduction: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) successfully demonstrated that multidomain lifestyle intervention can improve or maintain cognitive functioning in at-risk individuals. Hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70f16923b81385f6b21a674710a1000
https://doi.org/10.1016/j.eurger.2016.12.005

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The current standard measure of cardiorespiratory fitness introduces confounding by body mass: the DR's EXTRA study

Autor: Vesa Kiviniemi, Maija Hassinen, R. Rauramaa, P. Komulainen, Kai Savonen, Benno Krachler, Timo A. Lakka

Publikováno v: International Journal of Obesity. 36:1135-1140

Cardiorespiratory fitness is currently estimated by dividing maximal oxygen consumption (VO(2max)) by body weight (per-weight standard). However, the statistically correct way to neutralize the effect of weight on VO(2max) in a given population is ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cffc7e696576a2eac9ad5785c4e51a0
https://doi.org/10.1038/ijo.2011.212

Food consumption, nutrient intake and the risk of having metabolic syndrome: the DR's EXTRA Study

Autor: P. Komulainen, Ursula Schwab, Harri M. Heikkila, R. Rauramaa, R. Kouki, Maija Hassinen, Timo A. Lakka

Publikováno v: European Journal of Clinical Nutrition. 65:368-377

The associations of different components of diet with metabolic syndrome (MetS) are largely unknown. We therefore studied the associations of intakes of selected food items and nutrients with the risk of having MetS.The participants were a representa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d92d0f1ff67dbf123bdaf964d20b8b1
https://doi.org/10.1038/ejcn.2010.262