Zobrazeno 1 - 10
of 483
pro vyhledávání: '"R. Ratan"'
Autor:
Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Ajanta Chatterji, Angela P. Nguyen, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal Pileggi, Chet E. Holterman, Bojan Shutinoski, Juan Li, Travis K. Fehr, Matthew J. LaVoie, Rajiv R. Ratan, Gary S. Shaw, Masashi Takanashi, Nobutaka Hattori, Christopher R. Kennedy, Mary-Ellen Harper, Arne Holmgren, Julianna J. Tomlinson, Michael G. Schlossmacher
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn
Externí odkaz:
https://doaj.org/article/a0cf0ed0ee2143f0a980d7d5a5c6d50a
Autor:
J. R. Huie, A. R. Ferguson, N. Kyritsis, J. Z. Pan, K.-A. Irvine, J. L. Nielson, P. G. Schupp, M. C. Oldham, J. C. Gensel, A. Lin, M. R. Segal, R. R. Ratan, J. C. Bresnahan, M. S. Beattie
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Traumatic spinal cord injury (SCI) produces a complex syndrome that is expressed across multiple endpoints ranging from molecular and cellular changes to functional behavioral deficits. Effective therapeutic strategies for CNS injury are the
Externí odkaz:
https://doaj.org/article/e3769cfbde174ac4a0a3ca905c1c4a7c
Publikováno v:
Clinical Dermatology Review, Vol 5, Iss 2, Pp 187-191 (2021)
Background: The sudden outbreak of novel coronavirus has caused confusion, anxiety, and fear not only among the general public but also the health-care system. Considering widespread effects of the disease spilling into all aspects of life in general
Externí odkaz:
https://doaj.org/article/1366597623094a65a60d75454f45e64e
Autor:
Amit Kumar, Manisha Vaish, Saravanan S Karuppagounder, Irina Gazaryan, John W Cave, Anatoly A Starkov, Elizabeth T Anderson, Sheng Zhang, John T Pinto, Austin M Rountree, Wang Wang, Ian R Sweet, Rajiv R Ratan
Publikováno v:
eLife, Vol 10 (2021)
Hypoxic adaptation mediated by HIF transcription factors requires mitochondria, which have been implicated in regulating HIF1α stability in hypoxia by distinct models that involve consuming oxygen or alternatively converting oxygen into the second m
Externí odkaz:
https://doaj.org/article/5101dfdcd63d48c8a22c4fac2e9e0afc
Publikováno v:
Neurobiology of Disease, Vol 147, Iss , Pp 105145- (2021)
A major thrust of our laboratory has been to identify how physiological stress is transduced into transcriptional responses that feed back to overcome the inciting stress or its consequences, thereby fostering survival and repair. To this end, we hav
Externí odkaz:
https://doaj.org/article/061199407e804797a4505ad711ddd33c
Autor:
George Z Wei, Sujata Saraswat Ohri, Nicolas K Khattar, Adam W Listerman, Catherine H Doyle, Kariena R Andres, Saravanan S Karuppagounder, Rajiv R Ratan, Scott R Whittemore, Michal Hetman
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249591 (2021)
Traumatic spinal cord injury (SCI) is a devastating neurological condition that involves both primary and secondary tissue loss. Various cytotoxic events including hypoxia, hemorrhage and blood lysis, bioenergetic failure, oxidative stress, endoplasm
Externí odkaz:
https://doaj.org/article/afcf059cd1dc42a1bcc67fbc7242ecef
Autor:
Pascaline Aimé, Saravanan S. Karuppagounder, Apeksha Rao, Yingxin Chen, Robert E. Burke, Rajiv R. Ratan, Lloyd A. Greene
Publikováno v:
Neurobiology of Disease, Vol 136, Iss , Pp 104725- (2020)
Identifying disease-causing pathways and drugs that target them in Parkinson's disease (PD) has remained challenging. We uncovered a PD-relevant pathway in which the stress-regulated heterodimeric transcription complex CHOP/ATF4 induces the neuron pr
Externí odkaz:
https://doaj.org/article/e4d8cb29d6394909a61a7bb6794439bf
Autor:
Rajiv R, Ratan
Publikováno v:
Neuron. 110:3219-3222
Chemobrain is a variable but debilitating consequence of lifesaving cancer treatments. In this issue of Neuron, Jang and colleagues provide a new conceptual framework based on choroid plexus-CSF antioxidant status that advances understanding of chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f2a7c76ed6d8844ab7270e2577fbc3
https://doi.org/10.1016/j.neuron.2022.09.016
https://doi.org/10.1016/j.neuron.2022.09.016
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